ChemicalBook >> CAS DataBase List >>GSK2795039
GSK2795039
- CAS No.
- 1415925-18-6
- Chemical Name:
- GSK2795039
- Synonyms
- GSK2795039;GSK-2795039 (GSK 2795039;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
- CBNumber:
- CB13152080
- Molecular Formula:
- C23H26N6O2S
- Molecular Weight:
- 450.56
- MDL Number:
- MFCD30489720
- MOL File:
- 1415925-18-6.mol
Last updated:2023-06-30 15:45:59
| Boiling point | 691.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM) DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM) DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM) |
| form | A solid |
| pka | 6.99±0.30(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H334-H317-H341-H361-H370-H400-H410 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P301+P312-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P330-P362+P364-P333+P313-P342+P311-P363-P391-P405-P501 | |||||||||
| NFPA 704 |
|
GSK2795039 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2770 | GSK2795039 ≥98% (HPLC) | 1415925-18-6 | 1MG | $94.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2770 | GSK2795039 ≥98% (HPLC) | 1415925-18-6 | 5MG | $381 | 2024-03-01 | Buy |
| Tocris | 6848 | GSK2795039 ≥98%(HPLC) | 1415925-18-6 | 25 | $505 | 2021-12-16 | Buy |
| ChemScene | CS-5988 | GSK2795039 98.14% | 1415925-18-6 | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-5988 | GSK2795039 98.14% | 1415925-18-6 | 50mg | $1800 | 2021-12-16 | Buy |
GSK2795039 Chemical Properties,Uses,Production
Biological Activity
GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.
in vitro
GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.
Apoptosis Analysis p>
| Cell Line: | PC12 cells |
| 25 μM | |
| Incubation Time: | < td class="col2"> 24 hours|
| Result: | Reduced apoptosis among PC12 cells. | td>
target
| Target | Value |
| ROS () | |
| NADPH () | |
| NOX2 (HRP/Amplex Red) (Cell-based assay) | 6.57( pIC50) |
storage
Store at -20°C
GSK2795039 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK2795039 Suppliers
Global( 48)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 17988 | 64 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |
1415925-18-6(GSK2795039)Related Search:
GSK2795039
N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
GSK-2795039
(GSK 2795039
1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039
1415925-18-6