MMP-2 Inhibitor II
- CAS No.
- 869577-51-5
- Chemical Name:
- MMP-2 Inhibitor II
- Synonyms
- MMP-2 Inhibitor II;MMP-2 Inhibitor II - CAS 869577-51-5 - Calbiochem;MMP-2 Inhibitor II (Matrix Metalloproteinase-2 Inhibitor II);N-[4-[4-(oxiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanesulfonamide;N-[4-[4-[(2-oxiranylmethyl)sulfonyl]phenoxy]phenyl]-methanesulfonamide;Methanesulfonamide, N-[4-[4-[(2-oxiranylmethyl)sulfonyl]phenoxy]phenyl]-
- CBNumber:
- CB13152691
- Molecular Formula:
- C16H17NO6S2
- Molecular Weight:
- 383.44
- MDL Number:
- MFCD24369005
- MOL File:
- 869577-51-5.mol
MMP-2 Inhibitor II price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 444286-M | MMP-2 Inhibitor II - CAS 869577-51-5 - Calbiochem | 869577-51-5 | 5mg | $291 | 2024-03-01 | Buy |
| Cayman Chemical | 17267 | MMP-2 Inhibitor II ≥98% | 869577-51-5 | 1mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 17267 | MMP-2 Inhibitor II ≥98% | 869577-51-5 | 5mg | $369 | 2024-03-01 | Buy |
| Cayman Chemical | 17267 | MMP-2 Inhibitor II ≥98% | 869577-51-5 | 10mg | $698 | 2024-03-01 | Buy |
| ApexBio Technology | C5818 | MMP-2InhibitorII | 869577-51-5 | 1mg | $61 | 2021-12-16 | Buy |
MMP-2 Inhibitor II Chemical Properties,Uses,Production
General Description
An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (Ki = 2.4 μM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (Ki = 45 and 379 μM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.
Biological Activity
mmp-2 inhibitor ii is an irreversible, potent and selective mmp-2 inhibitor with ki value of 2.4 μm [1].matrix metalloproteinases (mmps) are zinc-dependent endopeptidases that play important roles in physiological and pathological conditions. two mmps, gelatinases a and b (mmp-2 and mmp-9, respectively), is highly expressed in human cancer, and a direct relationship between cancer progression and gelatinase expression and activity has been well established [1].mmp-2 inhibitor ii, an oxirane p-sulfonamido analog of sb-3ct, is an irreversible, potent and selective mmp-2 inhibitor. mmp-2 inhibitor ii inhibited mmp-2, mmp-1 and -7 with ki values of 2.4 μm, 45 and 379 μm, respectively, and didn’t inhibit mmp-3, -7, or -9 [1]. in bovine retinal endothelial cells, mmp-2 inhibitor ii reduced glucose-induced increases in the gelatinolytic activity of mmp-2 and mrna levels of mmp-2 and mt1-mmp. mmp-2 inhibitor ii also inhibited glucose-induced alterations in timp-2 and mt1-mmp gene expressions [2]. mmp-2 inhibitor ii had also been used to examine the role of mmp-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation [3].
Biochem/physiol Actions
Secondary TargetMMP-2 (Ki = 45 and 379 μM for MMP-1 and MMP-7, respectively)
References
[1]. ikejiri m, bernardo mm, bonfil rd, et al. potent mechanism-based inhibitors for matrix metalloproteinases. j biol chem. 2005 oct 7;280(40):33992-4002.
[2]. kowluru ra, kanwar m. oxidative stress and the development of diabetic retinopathy: contributory role of matrix metalloproteinase-2. free radic biol med. 2009 jun 15;46(12):1677-85.
[3]. xue m, mckelvey k, shen k, et al. endogenous mmp-9 and not mmp-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. rheumatology (oxford). 2014 dec;53(12):2270-9.
MMP-2 Inhibitor II Preparation Products And Raw materials
Raw materials
Preparation Products
MMP-2 Inhibitor II Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29803 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 12345678910 | hanfangpharma@126.com | China | 30968 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |