Tibenelast (sodium)
- CAS No.
- 105102-18-9
- Chemical Name:
- Tibenelast (sodium)
- Synonyms
- Tibenelast (sodium);5,6-diethoxy-1-benzothiophene-2-carboxylate
- CBNumber:
- CB13175597
- Molecular Formula:
- C13H13NaO4S
- Molecular Weight:
- 290.31
- MDL Number:
- MFCD00864802
- MOL File:
- 105102-18-9.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
| FDA UNII | V58CN2SY21 |
Tibenelast (sodium) Chemical Properties,Uses,Production
Uses
Tibenelast sodium is a phosphodiesterase inhibitor.
brand name
Tibenelast is INN.
in vivo
Tibenelast is a potent orally active compound against anaphylactic shock induced by high dose antigen aerosol. When a lower aerosol challenge (0.05 mg/mL) is employed, bronchoconstriction is observed with a concomitant increase in lung resistance (RL) and a fall in dynamic compliance (Cdyn). Tibenelast at 25 mg/kg p.o. prevents these changes. Tibenelast is 10 times more potent than Aminophylline by i.v. administration; normalization of pulmonary function is achieved at 1 mg/kg i.v. Tibenelast is synergistic with epinephrine. The oral dose response curve of Tibenelast is enhanced with the co-administration of epinephrine. Tibenelast may be of significant value in the treatment of asthma and other respiratory diseases[2].
References
[1] Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. DOI:10.1159/000139039
[2] Ho PP, et al. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25. PMID:232991
Tibenelast (sodium) Preparation Products And Raw materials
Raw materials
Preparation Products
Tibenelast (sodium) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29772 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24890 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
View Lastest Price from Tibenelast (sodium) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Tibenelast sodium
105102-18-9
|
US $1450.00-871.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Tibenelast sodium
105102-18-9
- US $1450.00-871.00 / mg
- TargetMol Chemicals Inc.