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HOE 140

HOE 140 structure

CAS No.: 130308-48-4

Chemical Name:: HOE 140

Synonyms: S-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP

CBNumber:: CB1318492

Molecular Formula:: C59H89N19O13S

Molecular Weight:: 1304.52

MDL Number:: MFCD00213940

MOL File:: 130308-48-4.mol

MSDS File:: SDS

Last updated:2024-04-19 20:05:26

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HOE 140 Properties

Density	1.60±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)
form	powder
pka	3.60±0.21(Predicted)
color	white
Water Solubility	Soluble to 1 mg/ml in water
Sequence	H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
InChIKey	QASONHYHOCRAHL-DOMVFXHKSA-N
CAS DataBase Reference	130308-48-4
FDA UNII	7PG89G35Q7
ATC code	B06AC02

SAFETY

Risk and Safety Statements

WGK Germany	3

HOE 140 price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	3014	HOE 140	130308-48-4	500U	$227	2021-12-16	Buy
Usbiological	255460	HOE 140	130308-48-4	500ug	$480	2021-12-16	Buy
ChemScene	CS-3381	Icatibant 99.51%	130308-48-4	5mg	$540	2021-12-16	Buy
AK Scientific	3729AH	Icatibant	130308-48-4	5mg	$610	2021-12-16	Buy
Apolloscientific	BISN0006	Icatibant 98%	130308-48-4	5mg	$660	2021-12-16	Buy

Product number	Packaging	Price	Buy
3014	500U	$227	Buy
255460	500ug	$480	Buy
CS-3381	5mg	$540	Buy
3729AH	5mg	$610	Buy
BISN0006	5mg	$660	Buy

HOE 140 Chemical Properties,Uses,Production

Description

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

Uses

Antagonist (bradykinin).

Definition

ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.

brand name

Metastat (CollaGenex).

storage

Store at -20°C

References

[1] K. Wirth. “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.” British Journal of Pharmacology 102 3 (1991): 774–777.
[2] T Sakamoto. “Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.” European journal of pharmacology 213 3 (1992): 367–73.

HOE 140 Preparation Products And Raw materials

Raw materials

Preparation Products

HOE 140 Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Xinhao Biotechnology Co., Ltd	+86-18120578002 +86-18120578002	xinhao-6@xinhaoshengwu.com	China	350	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Shanghai Aosiris new Material Technology Co., LTD	86-15139564871 +8615139564871	wrjmoon2000@163.com	China	354	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Beijing Yibai Biotechnology Co., Ltd	0086-182-6772-3597	sales04@yibaibiotech.com	CHINA	419	58

Supplier	Advantage
Wuhan Xinhao Biotechnology Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shanghai Aosiris new Material Technology Co., LTD	58
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Beijing Yibai Biotechnology Co., Ltd	58

View Lastest Price from HOE 140 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Icatibant 130308-48-4	US $50.00 / box	1box	>99%	tons	Hong Kong Excellence Biotechnology Co., Ltd.
2024-04-19	HOE 140 130308-48-4	US $3.00-1.00 / kg	1kg	99.9%	10 tons	Shanghai Aosiris new Material Technology Co., LTD
2024-04-02	HOE 140 130308-48-4	US $10.00-100.00 / kg	1kg	99%	100 tons	Wuhan Xinhao Biotechnology Co., Ltd

Icatibant
130308-48-4
US $50.00 / box
>99%
Hong Kong Excellence Biotechnology Co., Ltd.

HOE 140
130308-48-4
US $3.00-1.00 / kg
99.9%
Shanghai Aosiris new Material Technology Co., LTD

HOE 140
130308-48-4
US $10.00-100.00 / kg
99%
Wuhan Xinhao Biotechnology Co., Ltd

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1of4

RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R H-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH H2N-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH Icatibant D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Thi-L-Ser-D-Tic-L-Oic-L-Arg-OH H0E-140 D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-3-(2-Thienyl)-L-Ala-L-Ser-D-Tic-[(3aS,7aS)-L-Oic-]-OH Des-Arg9-D-Arg[Hyp3,Thi5,D-Tic7,Oic8]bradykinin S-0765 138614-30-9 (Acetate) Icatibant [inn] L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl- HOE I40 HOE 140 HOE 140 2ACOH 4H2O D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG 2ACOH 4H2O D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ 2ACOH 4H2O D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA, 3BETA, 7ABETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA,3BETA,7A-BETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL-L-ARGININE [DES-ARG10] HOE 140 D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic D-Arg-L-Arg-L-prolyl-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carboxylic acid HOE 140 USP/EP/BP L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl- Nw-(((S)-2-(2-((2S,4R)-1-(D-arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-N2-((3aS,7aS)-octahydro-1H-indole-2-carbonyl)-N2-((R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-arginine JE-049) Icatibant (HOE-140 Icatibatide Acetate Etibant Phytol Impurity 3 HOE 140 TFA ((2S,3aS,7aS)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-Arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)octahydro-1H-indole-2-carbonyl)-L-arginine 130308-48-4 C53H77N15O12S C59H90N20O12S peptide