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Cosyntropin

Cosyntropin
Cosyntropin structure
CAS No.
16960-16-0
Chemical Name:
Cosyntropin
Synonyms
C06926;acth-z;ba30920;ba36716;actholain;cortrosyn;synacthen;synecthen;α1-24-ACTH;ACTH (1-24)
CBNumber:
CB1325409
Molecular Formula:
C136H210N40O31S
Formula Weight:
2933.47
MOL File:
16960-16-0.mol

Cosyntropin Properties

Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Sparingly soluble in water.
Water Solubility 
Soluble in water
InChIKey
ZOEFCCMDUURGSE-SQKVDDBVSA-N
CAS DataBase Reference
16960-16-0(CAS DataBase Reference)
FDA UNII
72YY86EA29
SAFETY
  • Risk and Safety Statements
WGK Germany  3
RTECS  GM7915000
HS Code  2937220000

Cosyntropin price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A0298 Adrenocorticotropic Hormone Fragment 1-24 human, rat ≥97% (HPLC) 16960-16-0 1mg $219 2019-12-02 Buy
Sigma-Aldrich 1150115 Adrenocorticotropic Hormone Fragment 1-24 human, rat 16960-16-0 1.69mg $499.8 2018-11-20 Buy
Alfa Aesar J66365 Adrenocorticotropic Hormone (1-24), human 16960-16-0 0.5mg $71.8 2019-12-02 Buy
Alfa Aesar J66365 Adrenocorticotropic Hormone (1-24), human 16960-16-0 1mg $113 2019-12-02 Buy
Sigma-Aldrich A0298 Adrenocorticotropic Hormone Fragment 1-24 human, rat ≥97% (HPLC) 16960-16-0 250ug $76.2 2019-12-02 Buy

Cosyntropin Chemical Properties,Uses,Production

Chemical Properties

White or yellow, amorphous powder.

Uses

Hormone (adrenocorticotropic).

Indications

Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.

Definition

ChEBI: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of cort costeroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.

brand name

Cortrosyn (Amphastar).

General Description

Cosyntropin (Cortrosyn) is a syntheticpeptide containing the first 24 amino acids of natural corticotropin.Cosyntropin is used as a diagnostic agent to testfor adrenal cortical deficiency. Plasma hydrocortisone concentrationis determined before and 30 minutes after theadministration of 250 g of cosyntropin. Most normal responses result in an approximate doubling of the basalhydrocortisone concentration in 30 to 60 minutes. If the responseis not normal, adrenal insufficiency is indicated.Such adrenal insufficiency could be a result of either adrenalor pituitary malfunction, and further testing is requiredto distinguish between the two. Cosyntropin (250 μg infusedwithin 4–8 hours) or corticotropin (80–120 U/day for3–4 days) is administered. Patients with functional adrenaltissue should respond to this dosage. Patients who respondaccordingly are suspected of hypopituitarism, and the diagnosiscan be confirmed by other tests for pituitary function.Patients who have Addison disease, however, show little orno response.

Veterinary Drugs and Treatments

Cosyntropin is used primarily as an alternative to ACTH to test for adrenocortical insufficiency (Addison’s), or hyperadrenocorticism, particularly in animals who have reacted immunologically to corticotropin in the past or if ACTH gel is unavailable.

Cosyntropin Preparation Products And Raw materials

Raw materials

Preparation Products


Cosyntropin Suppliers

Global( 132)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Cellmano Biotech Limited
+86-551-65326643
+86-551-65326641 info@cellmano.com CHINA 1044 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales03@yibaibiotech.com CHINA 420 58

View Lastest Price from Cosyntropin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Cosyntropin
16960-16-0
US $7.00 / KG 1KG 99% 100kg career henan chemical co
2018-12-24 Cosyntropin
16960-16-0
US $7.00 / kg 1kg 99% 100kg career henan chemical co

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