ChemicalBook >> CAS DataBase List >>(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

CAS No.
1987887-92-2
Chemical Name:
(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Synonyms
Nintedanib-011;Intedanib Impurity D;Nintedanib Impurity q;Nintedanib Impurity 34;Nintedanib impuritiesD;Nintedanib impurities25;NintedanibN-Methylimpurity;Nintedanib N-Methyl Aniline Analog;(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)meth...;(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylen...
CBNumber:
CB13335038
Molecular Formula:
C24H21N3O3
Molecular Weight:
399.44
MDL Number:
MOL File:
1987887-92-2.mol
Last updated:2023-04-23 13:52:06

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Properties

Melting point 273 - 276°C
Boiling point 641.3±55.0 °C(Predicted)
Density 1.316±0.06 g/cm3(Predicted)
storage temp. Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 11.16±0.20(Predicted)
form Solid
color Yellow to Orange

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D492443 (3Z)​-2,​3-Dihydro-​3-​[[[4-​(methylamino)​phenyl]​amino]​phenylmethylene]​-​2-​oxo-​1H-​Indole-​6-​carboxylicAcidMethylEster 1987887-92-2 5mg $255 2021-12-16 Buy
Product number Packaging Price Buy
D492443 5mg $255 Buy

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Chemical Properties,Uses,Production

Uses

(3Z)?-2,?3-Dihydro-?3-?[[[4-?(methylamino)?phenyl]?amino]?phenylmethylene]?-?2-?oxo-?1H-?Indole-?6-?carboxylic Acid Methyl Ester is an impurity of Nintedanib (N478290), an angiokinase inhibitor and is used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Intedanib Impurity D Nintedanib Impurity 34 Nintedanib-011 Nintedanib impurity 10/(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)meth... 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- Nintedanib Impurity q (3Z)?-2,?3-Dihydro-?3-?[[[4-?(methylamino)?phenyl]?amino]?phenylmethylene]?-?2-?oxo-?1H-?Indole-?6-?carboxylic Acid Methyl Ester (Z)-Methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate (Nintedanib Impurity) (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylen... Nintedanib impurities25 Nintedanib impuritiesD NintedanibN-Methylimpurity Nintedanib N-Methyl Aniline Analog 1987887-92-2