ChemicalBook >> CAS DataBase List >>Betamethasone 21-acetate

Betamethasone 21-acetate

CAS No.
987-24-6
Chemical Name:
Betamethasone 21-acetate
Synonyms
BETAMETHASONE ACETATE;Betamethasone 21-ace;BETAMETHASONE 21-ACETATE;Betamethasone 21-Acetata;Betamethasone acetate CRS;Betamethasone Acetate API;Betamethasone21-acetatemicro;Betamethasone-21 acetate salt;Betamethasone Acetate (500 mg);BETAMETHASONE ACETATE LINIMENTS
CBNumber:
CB1337284
Molecular Formula:
C24H31FO6
Molecular Weight:
434.5
MDL Number:
MFCD00867462
MOL File:
987-24-6.mol
MSDS File:
SDS
Last updated:2023-09-01 17:37:15

Betamethasone 21-acetate Properties

Melting point 200-220°C (dec.)
alpha D +140° (chloroform)
Boiling point 579.4±50.0 °C(Predicted)
Density 1.0932 (rough estimate)
refractive index 1.5980 (estimate)
storage temp. Refrigerator
solubility Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pka 12.08±0.70(Predicted)
color White to Off-White
Water Solubility 30mg/L(25 ºC)
Merck 14,1180
CAS DataBase Reference 987-24-6(CAS DataBase Reference)
FDA UNII TI05AO53L7
EPA Substance Registry System .beta.-Methasone acetate (987-24-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360FD-H373
Precautionary statements  P202-P260-P280-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  40
Safety Statements  22-36
WGK Germany  3
HS Code  2937220000

Betamethasone 21-acetate price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1779 Betamethasone acetate Pharmaceutical Secondary Standard; Certified Reference Material 987-24-6 1g $267 2024-03-01 Buy
Sigma-Aldrich 1067001 Betamethasone acetate United States Pharmacopeia (USP) Reference Standard 987-24-6 500mg $436 2024-03-01 Buy
Sigma-Aldrich B1030000 Betamethasone acetate European Pharmacopoeia (EP) Reference Standard 987-24-6 b1030000 $220 2024-03-01 Buy
TRC B327025 Betamethasone21-Acetate 987-24-6 1g $1185 2021-12-16 Buy
TRC B327025 Betamethasone21-Acetate 987-24-6 5mg $95 2021-12-16 Buy
Product number Packaging Price Buy
PHR1779 1g $267 Buy
1067001 500mg $436 Buy
B1030000 b1030000 $220 Buy
B327025 1g $1185 Buy
B327025 5mg $95 Buy

Betamethasone 21-acetate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Celestone Soluspan,Schering,US,1965

Uses

CORTICOSTEROID

Uses

amino acid, nutrient

Uses

Betamethasone acetate (BA)

Definition

ChEBI: Betamethasone acetate is an acetate ester, a steroid ester, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, an 11beta-hydroxy steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone.

Manufacturing Process

The synthesis is long and complex. For brevity, only the last steps are given here. Refer to the patents cited below for full details.
Preparation of 9α-Bromo-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a mixture of 620 mg of 17α,21-dihydroxy-16β-methyl- 4,9(11)-pregnadiene-3,20-dione 21-acetate and 330 mg of Nbromosuccinimide in 10 ml of dioxane and 3.2 ml of water cooled to 10°C was added 1.8 ml of cold 1 M aqueous perchloric acid. The mixture was stirred at 15°C for 3 hours. Excess N-bromosuccinimide was destroyed by addition of aqueous sodium thiosulfate and most of the dioxane was removed in vacuo. About 30 ml of water was added and crystalline bromohydrin, 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate, was filtered, washed with water, and dried in air. Preparation of 9β,11β-Epoxy-17α-21-Dihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a stirred solution of 100 mg of the 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate in 3 ml of tetrahydrofuran and 1 ml of methanol under nitrogen was added 1.02 ml of 0.215N methanolic sodium methoxide. After 10 minutes at 25°C, 0.2 ml of acetic acid was added and the methanol removed in vacuo. The residue was acetylated with 1.00 ml of pyridine and 0.5 ml of acetic anhydride at 60°C for 70 minutes. The mixture was taken to dryness in vacuo, water added, and the product extracted into chloroform. The residue was crystallized from etheracetone to give pure 9β,11β-epoxy-17α,21-dihydroxy-16β-methyl-4-pregnene- 3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a solution of 200 mg of 9β,11β-epoxy-17α,21-dihydroxy- 16β-methyl-4-pregnene-3,20-dione 21-acetate in 2 ml of chloroform and 2 ml of tetrahydrofuran in a polyethylene bottle at -60°C was added 2 ml of a 2:1 (by weight) mixture of anhydrous hydrogen fluoride and tetrahydrofuran. After 4 hours at -10°C the mixture was cooled to -60°C and cautiously added to a stirred mixture of 30 ml or 25% aqueous potassium carbonate and 25 ml of chloroform kept at -5°C. The aqueous phase was further extracted with chloroform and the latter phase washed with water and dried over magnesium sulfate. The residue on crystallization from acetone-ether gave pure 9α-fluoro- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnadiene- 3,20-Dione 21-Acetate 100 mg of 9α-fluoro-11β,17α,21-trihydroxy-16β- methyl-4-pregnene-3,20-dione 21-acetate was treated with selenium dioxide to produce the corresponding 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-4- pregnadiene-3,20-dione 21-acetate. Alternately, Bacillus sphaericus may be utilized.

Therapeutic Function

Glucocorticoid

467-55-0
987-24-6
Synthesis of Betamethasone 21-acetate from Hecogenin

Betamethasone 21-acetate Preparation Products And Raw materials

Global( 274)Suppliers
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Hebei Mojin Biotechnology Co., Ltd
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View Lastest Price from Betamethasone 21-acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Betamethasone 21-acetate/Betamethasone Acetate  pictures 2024-03-26 Betamethasone 21-acetate/Betamethasone Acetate
987-24-6
US $0.00-0.00 / KG 1KG 99% 5000 Wuhan Haorong Biotechnology Co.,Ltd
Betamethasone 21-acetate pictures 2023-09-01 Betamethasone 21-acetate
987-24-6
US $100.00 / bag 1bag 99 5000 Hebei Fengqiang Trading Co., LTD
Betamethasone 21-acetate pictures 2023-08-12 Betamethasone 21-acetate
987-24-6
US $0.00 / kg 1kg 99% 1000tons Hebei Mojin Biotechnology Co., Ltd
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 21-Acetate 9alpha-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate (11β,16β)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione BETAMETHASONE ACETATE LINIMENTS (17R)-16β-Methyl-21-acetoxy-11β,17α-dihydroxy-9α-fluoropregna-1,4-diene-3,20-dione 21-Acetyloxy-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Betamethasone Acetate (500 mg) Betamethasone 21-ace 9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE 9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate BETAMETHASONE 21-ACETATE 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate Betamethasone acetate BP/USP/EP BETAMETHASONE ACETATE EPB(CRM STANDARD) BETAMETHASONE ACETATE MM(CRM STANDARD) BETAMETHASONE ACETATE USP(CRM STANDARD) Betamethasone21-acetatemicro Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11.beta.,16.beta.)- BETAMETHASONEACETATE,MICRONIZED,USP Betamethasone acetate CRS Betamethasone acetate Solution in Acetonitrile, 100μg/mL Betamethasone 21-acetate USP/EP/BP Betamethasone 21-Acetate D3Q: What is Betamethasone 21-Acetate D3 Q: What is the CAS Number of Betamethasone 21-Acetate D3 Q: What is the storage condition of Betamethasone 21-Acetate D3 Q: What are the applications of Betamethasone 21-Acetate D3 Betamethasone Acetate-d4Q: What is Betamethasone Acetate-d4 Q: What is the CAS Number of Betamethasone Acetate-d4 Betamethasone acetateQ: What is Betamethasone acetate Q: What is the CAS Number of Betamethasone acetate Q: What is the storage condition of Betamethasone acetate Betamethasone Acetate API Betamethasone Acetate (1067001) Dexamethasone Acetate Impurity 4(Dexamethasone Acetate EP Impurity D) Betamethasone 21-Acetata Betamethasone-4,6,11,12,12-d5 21-Acetate BETAMETHASONE ACETATE 2-((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate Dexamethasone Acetate Impurity D Betamethasone Acetate Corticosteroid Raw Powder Betamethasone-21 acetate salt Betamethasone 21-acetate/Betamethasone Acetate Dexamethasone Acetate EP Impurity D (Betamethasone acetate) 1, 4-PREGNADIEN-9α-FLUORO-16β-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-ACETATE 987-24-6 4345 Cytokines, Growth Factors and Hormones Cell Biology Cell Signaling and Neuroscience BioChemical Hormones Steroid Hormones Intermediates & Fine Chemicals Pharmaceuticals Intracellular receptor Biochemistry Hydroxyketosteroids Steroids