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Trichloroacetyl isocyanate

Trichloroacetyl isocyanate Structure
Trichloroacetyl isocyanate structure
CAS No.
3019-71-4
Chemical Name:
Trichloroacetyl isocyanate
Synonyms
2,2,2-TRICHLOROACETYL ISOCYANATE;trichloroethanecarbonyl isocyanate;Trichloroacetyl isocyate;trichloro-acetylisocyanat;TRICHLOROACETYL ISOCYANATE;Acetyl isocyanate, trichloro-;Trichloroacetyl isocyanate ,97%;Trichloroacetyl isocyanate, GC 97%;Acetyl isocyanate, 2,2,2-trichloro-;Isocyanic Acid Trichloroacetyl Ester
CBNumber:
CB1337310
Molecular Formula:
C3Cl3NO2
Molecular Weight:
188.4
MDL Number:
MFCD00002033
MOL File:
3019-71-4.mol
MSDS File:
SDS
Last updated:2024-04-23 16:26:43
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Trichloroacetyl isocyanate Properties

Melting point 135-140 °C
Boiling point 80-85 °C/20 mmHg (lit.)
Density 1.581 g/mL at 25 °C (lit.)
refractive index n20/D 1.480(lit.)
Flash point 150 °F
storage temp. 2-8°C
solubility Miscible with dichloromethane, ether, terahydrofuran and protic solvents.
form Liquid
color Clear colorless to slightly yellow
Water Solubility Decomposition
Sensitive Moisture Sensitive
BRN 971201
Stability Hygroscopic, Moisture Sensitive
InChIKey GRNOZCCBOFGDCL-UHFFFAOYSA-N
CAS DataBase Reference 3019-71-4(CAS DataBase Reference)
FDA UNII QXV1P5J6JL
NIST Chemistry Reference Trichloroacetyl isocyanate(3019-71-4)
EPA Substance Registry System Acetyl isocyanate, trichloro- (3019-71-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H311+H331-H314-H317-H334
Precautionary statements  P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  14-23/24-34-42-23/24/25-36/37/38
Safety Statements  23-26-36/37/39-45-8-7/9
RIDADR  UN 2206 6.1/PG 3
WGK Germany  3
F  10-19
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29291090
NFPA 704
2
3 0
W

Trichloroacetyl isocyanate price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 217328 Trichloroacetyl isocyanate 96% 3019-71-4 1g $56.6 2024-03-01 Buy
Sigma-Aldrich 217328 Trichloroacetyl isocyanate 96% 3019-71-4 10g $137 2024-03-01 Buy
TCI Chemical T1047 Trichloroacetyl Isocyanate >97.0%(N) 3019-71-4 1g $53 2024-03-01 Buy
TCI Chemical T1047 Trichloroacetyl Isocyanate >97.0%(N) 3019-71-4 5g $159 2024-03-01 Buy
Alfa Aesar L00226 Trichloroacetyl isocyanate 97% 3019-71-4 2g $34.65 2024-03-01 Buy
Product number Packaging Price Buy
217328 1g $56.6 Buy
217328 10g $137 Buy
T1047 1g $53 Buy
T1047 5g $159 Buy
L00226 2g $34.65 Buy

Trichloroacetyl isocyanate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

Trichloroacetyl isocyanate was used in catalytic one-pot dehydrative glycosylation of 1-hydroxy carbohydrate. It was also used as a reagent for the conversion of alcohols to carbamates.

Application

Trichloroacetyl Isocyanate is used as an in situ derivatizing reagent for characterization of alcohols, glycols, phenols, and amines by nuclear magnetic resonance (NMR).It has been reported in the literature that it can be used for the preparation of cefuroxime axetil.

Preparation

Trichloroacetyl isocyanate can be obtained by reacting 2,2,2-trichloroacetamide with oxalyl chloride.
Procedure: A reaction mixture of 2,2,2-trichloroacetamide (100 g, 616 mmol, 1.0 eq) in (COCl)2 (725 g, 5.71 mol, 500 mL, 9.28 eq) was heated to 70°C for 24 hours. The reaction mixture was concentrated under vacuum. To the mixture was added 1,2,4-trichlorobenzene (500 mL) and (COCl)2 (116 g, 914 mmol, 80 mL, 1.48 eq). The reaction mixture was stirred at 100°C for 5 hours. Heat to 125°C for 15 hours. The mixture was then heated to 140°C for 5 hours. The reaction mixture was distilled under water pump (72°C-76°C fractions) to give trichloroacetyl isocyanate (60 g, 319 mmol, 52% yield) as a colorless oil.

General Description

Conformational stability and vibrational IR and Raman spectra of trichloroacetyl isocyanate has been investigated. Trichloroacetyl isocyanate is commonly employed as in situ derivatizing reagent for the 13C NMR studies of alcohols, phenols and amines. It undergoes 1,5-cycloaddition reaction with anhydro-2-deoxy-D-erythro- and -L-threo-pent-1-enitols and 1,5-anhydro-2-deoxy-D- and -L-arabino-hex-1-enitols to yield [2+2] and [4+2] cycloadducts.

Trichloroacetyl isocyanate Preparation Products And Raw materials

Raw materials

Trichloroacetyl chloride Sodium cyanate 1,2,4-Trichlorobenzene

Preparation Products

Cefuroxime Carisoprodol 2-Ethoxybenzamide Carbamic acid 2-propynyl ester MFCD19982270
1-Oxa-3-azaspiro[4.4]nonane-2,4-dione(6CI,9CI)

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Trichloroacetyl isocyanate Suppliers

Global( 162)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9641 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10326 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
Wuhan Boye Science And Technology Development Co., Ltd. 		27-81625225 +8615387090420 sumihu@boyechemicals.com CHINA 215 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58
Hubei Ipure Biology Co., Ltd 		58
Career Henan Chemica Co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Wuhan Boye Science And Technology Development Co., Ltd. 		58

View Lastest Price from Trichloroacetyl isocyanate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trichloroacetyl isocyanate pictures 2024-04-23 Trichloroacetyl isocyanate
3019-71-4
 US $10.00 / kg 1kg 99.8% 10000ton Ouhuang Engineering Materials (Hubei) Co., Ltd
Trichloroacetyl isocyanate pictures 2023-11-13 Trichloroacetyl isocyanate
3019-71-4
 US $2759.64 / KG 1KG 97% 500KG Wuhan Boye Science And Technology Development Co., Ltd.
Trichloroacetyl isocyanate pictures 2023-06-28 Trichloroacetyl isocyanate
3019-71-4
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd

Trichloroacetyl isocyanate Spectrum

Trichloroacetyl isocyanate(3019-71-4)MSTrichloroacetyl isocyanate(3019-71-4)1HNMRTrichloroacetyl isocyanate(3019-71-4)13CNMRTrichloroacetyl isocyanate(3019-71-4)IRTrichloroacetyl isocyanate(3019-71-4)RamanTrichloroacetyl isocyanate(3019-71-4)FT-IR

3019-71-4(Trichloroacetyl isocyanate)Related Search:

Propyl isocyanate Trichloroacetyl chloride Isocyanatocyclohexane ISOCYANIC ACID Trimethylsilylacetylene
Trimethyloxonium Tetrafluoroborate TRICHLOROACETIC ANHYDRIDE N-HEXADECYLTRICHLOROSILANE HEXYLTRICHLOROSILANE CYCLOPENTYLTRICHLOROSILANE
3-phenylpropyltrichlorosilane ISOCYANATE Chloroacetamide 2,2,2-Trichloroacetamide 2-Chloroethyl isocyanate
METHYLISOCYANATE 1 X 500MG NEAT Ethylamine hydrochloride Chloroform

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Trichloroacetyl isocyate TRICHLOROACETYL ISOCYANATE Acetyl isocyanate, trichloro- trichloro-acetylisocyanat Trichloroacetyl isocyanate, NMR grade Isocyanic Acid Trichloroacetyl Ester Trichloroacetyl isocyanate, GC 97% Trichloroacetyl isocyanate ,97% 1-Oxo-2,2,2-trichloroethyl isocyanate Trichloroacetyl isocyanate, NMR grade 10GR TRICHLOROACETYL ISOCYANATE FOR SYNTHESIS Trichloroacetyl isocyanate puruM, >=97.0% (GC) Trichloroacetyl Isocyanate, 98.0%(N) Acetyl isocyanate, 2,2,2-trichloro- 2,2,2-TRICHLOROACETYL ISOCYANATE trichloroethanecarbonyl isocyanate 3019-71-4 C3Cl3NO2 Cl3CCONCO Isocyanates Nitrogen Compounds Organic Building Blocks Building Blocks Organics Isocyanates Nitrogen Compounds Organic Building Blocks Building Blocks Chemical Synthesis Nitrogen Compounds Organic Building Blocks