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Ninhydrin hydrate

Ninhydrin hydrate
Ninhydrin hydrate structure
CAS No.
485-47-2
Chemical Name:
Ninhydrin hydrate
Synonyms
NIN;Ningidrin;NINHYDRIN;NyNhydriN;Ninthydrin;NINHYDRINE;NinhydrinGr;Ninhydrin99%;Ninhydrin>NinhydrinA.R.
CBNumber:
CB1337916
Molecular Formula:
C9H6O4
Formula Weight:
178.14
MOL File:
485-47-2.mol

Ninhydrin hydrate Properties

Melting point:
250 °C (dec.) (lit.)
Boiling point:
230.35°C (rough estimate)
Density 
0.862
vapor density 
6.16 (vs air)
refractive index 
1.4209 (estimate)
Flash point:
13 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
ethanol: soluble100mg/mL
form 
Powder/Solid
pka
8.47±0.20(Predicted)
color 
white to brownish-white, crystals
Specific Gravity
0.788
PH
4.6-5.0 (10g/l, H2O, 20℃)
Odor
Odorless
PH Range
4.6 - 5.0
Water Solubility 
0.1-0.5 g/100 mL at 20 ºC
Sensitive 
Light Sensitive
Merck 
14,6554
BRN 
1910963
Stability:
Stable. Incompatible with amines, alkalies, strong bases. Light-sensitive.
InChIKey
FEMOMIGRRWSMCU-UHFFFAOYSA-N
CAS DataBase Reference
485-47-2(CAS DataBase Reference)
EWG's Food Scores
4-7
FDA UNII
HCL6S9K23A
NIST Chemistry Reference
Ninhydrin(485-47-2)
EPA Substance Registry System
Ninhydrin (485-47-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS02,GHS08
Signal word  Warning
Hazard statements  H335+H336-H340-H360-H372-H373-H335-H302-H315-H319-H225-H334
Precautionary statements  P261-P280a-P304+P340-P501a-P301+P312+P330-P305+P351+P338-P201-P202-P210-P233-P240-P241+P242+P243-P260-P264-P270-P271-P280-P284-P302+P352+P332+P313+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P308+P313-P403+P233-P405-P501
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-39/23/24/25-20/21/22-11
Safety Statements  26-28A-45-16-36
RIDADR  UN 1170 3/PG 2
WGK Germany  3
RTECS  NK5425000
8
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29144000
Toxicity LD50 orally in Rabbit: 600 mg/kg
NFPA 704
1
2 1

Ninhydrin hydrate price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 151173 Ninhydrin ACS reagent 485-47-2 10g $47.3 2021-03-22 Buy
Sigma-Aldrich 1.06762 Ninhydrin GR for analysis ACS,Reag. Ph Eur 485-47-2 10 g $60.31 2021-03-22 Buy
Sigma-Aldrich 151173 Ninhydrin ACS reagent 485-47-2 25g $68.9 2021-03-22 Buy
Sigma-Aldrich 1.06762 Ninhydrin GR for analysis ACS,Reag. Ph Eur 485-47-2 100 g $295.07 2021-03-22 Buy
Sigma-Aldrich 1.06762 Ninhydrin GR for analysis ACS,Reag. Ph Eur 485-47-2 1 kg $2386.5 2021-03-22 Buy

Ninhydrin hydrate Chemical Properties,Uses,Production

Description

Ninhydrin is historically the most common reagent for processing fingerprints on porous substrates. It has been used as a fingerprint reagent since the 1950s but has been used as a cell stain since the early 1900s. Ninhydrin molecules form a complex with amino acids resulting in a purple product known as Ruhmann's purple. Purple fingerprints are easily visible on light-colored porous substrates but may be difficult to see on patterned or dark-colored substrates. DFO reacts with amino acids to produce a fluorescent product that is not readily seen with the naked eye. This makes it a useful reagent on dark or patterned porous items. DFO prints are viewed with an alternate light source or laser set to 530–570 nm (green light) through a red barrier filter. 1,2-indanedione is an emerging fingerprint reagent that results in visible pink fingerprints that are also fluorescent. The fluorescence is viewed under the same conditions as DFO.
These chemicals can be used on their own or in sequence to develop latent prints on porous substrates. If they are used in sequence, they are used in the following order: indanedione, DFO, ninhydrin. If a reagent is used out of sequence, it will inhibit or limit the effectiveness of the other reagents. In this laboratory exercise you will develop fingerprints on a porous substrate using indanedione, DFO, and ninhydrin.
ninhydrin structure
ninhydrin structure

Chemical Properties

White to pale yellow crystalline powder

Uses

Used for the detection of free amino groups in amino acids, peptides and proteins.

Uses

Ninhydrin is an amino acid-sensitive reagent for the development of latent fingermarks on porous surfaces. More sensitive alternatives, such as DFO and IND-Zn, are now available and these have advantages on porous substrates that are not highly luminescent. However, ninhydrin can still be applied after these treatments and may reveal additional ridge detail, particularly on highly luminescent substrates where luminescence visualization may be problematic.

Definition

ChEBI: A member of the class of indanones that is indane-1,3-dione bearing two additional hydroxy substituents at position 2.

Reactions

Ninhydrin reacts with primary and secondary amines (including amino acids, proteins, and peptides) to give a dark purple product known as Ruhemann's purple (RP) . As the eccrine component of a latent mark deposit contains amino acids, this reaction can be exploited as a means of developing fingermarks on porous surfaces such as paper and cardboard. The use of ninhydrin as a fingermark detection reagent was first proposed in 1954 by Odén and von Hofsten (1954). Since then, ninhydrin has become the most popular technique for fingermark detection on porous substrates.
Eccrine glands secrete a range of different amino acids that may ultimately be present in a latent fingermark deposit (Hamilton 1965; Ramotowski 2001). Ninhydrin is a nonspecific amino acid reagent in that it reacts in the same manner with different amino acids. In this way, each amino acid present in the latent fingermark deposit will contribute to the developed fingermark image. Amino acids are stable compounds that, due to an affinity for cellulose, do not migrate to any significant extent through dry paper substrates. As a result, very old latent marks can be developed with ninhydrin (the development of 40-year-old marks has been recorded), and the revealed marks are normally of good quality. In addition, the amino acid composition of the eccrine secretion appears to remain relatively constant. Due to these qualities, the use of amino acid reagents (ninhydrin and ninhydrin analogs, including 1,8-diazafluoren-9-one [DFO]) constitutes an effective chemical technique for the development of latent fingermarks on paper surfaces.

Synthesis Reference(s)

Synthetic Communications, 24, p. 695, 1994 DOI: 10.1080/00397919408012648
Tetrahedron Letters, 9, p. 6201, 1968

General Description

White to light yellow crystals or powder. Becomes anhydrous with reddening at 257-266°F.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Ninhydrin hydrate is sensitive to prolonged exposure to light. Ninhydrin hydrate yields highly fluorescent ternary compounds with aldehydes and primary amines.

Hazard

Irritant.

Fire Hazard

Flash point data for Ninhydrin hydrate are not available. Ninhydrin hydrate is probably combustible.

Purification Methods

Crystallise ninhydrin from hot water (charcoal). Dry it under vacuum and store it in sealed brown containers. [Beilstein 7 IV 2786.]

Ninhydrin hydrate Preparation Products And Raw materials

Raw materials

Preparation Products


Ninhydrin hydrate Suppliers

Global( 352)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
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029-88380327 1015@dideu.com CHINA 4149 58

View Lastest Price from Ninhydrin hydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-12 Ninhydrin hydrate
485-47-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-13 Ninhydrin hydrate
485-47-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Ninhydrin hydrate
485-47-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Ninhydrin hydrate Spectrum


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