ChemicalBook >> CAS DataBase List >>Aconitine


Chemical Name:
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Modify Date:
2022-08-11 17:36:44

Aconitine Properties

Melting point 200-205 °C (dec.)
alpha D +17.3° (chloroform)
Boiling point 675.12°C (rough estimate)
Density 1.2181 (rough estimate)
refractive index 1.6630 (estimate)
storage temp. Refrigerator
pka 5.88(at 25℃)
form White to off-white powder.
Water Solubility Soluble in ethanol. Sparingly soluble in water
Merck 13,120
CAS DataBase Reference 302-27-2
EWG's Food Scores 1-5
NIST Chemistry Reference Aconitine(302-27-2)


Risk and Safety Statements

Signal word  Danger
Hazard statements  H300+H330
Precautionary statements  P301+P310+P330-P304+P340+P310
Hazard Codes  T+,Xi
Risk Statements  26/28-36/37/38
Safety Statements  24-45-36-26
RIDADR  UN 1544 6.1/PG 1
WGK Germany  2
RTECS  AR5960000
HazardClass  6.1(a)
PackingGroup  I
Toxicity LD50 in mice (mg/kg): 0.166 i.v.; 0.328 i.p.; approx 1 orally (Dybing); also reported as LD50 in mice (mg/kg): 1.8 orally, 0.270 s.c.; 0.380 i.p.; 0.12 i.v. (Sato)

Aconitine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A8001 Aconitine ≥95% (HPLC), crystalline 302-27-2 5mg $51.4 2022-05-15 Buy
Sigma-Aldrich A8001 Aconitine ≥95% (HPLC), crystalline 302-27-2 25mg $186 2022-05-15 Buy
Sigma-Aldrich A8001 Aconitine ≥95% (HPLC), crystalline 302-27-2 100mg $561 2022-05-15 Buy
Sigma-Aldrich A8001 Aconitine ≥95% (HPLC), crystalline 302-27-2 250mg $1190 2022-05-15 Buy
Alfa Aesar J62056 Aconitine 98% 302-27-2 250mg $766 2022-04-27 Buy
Product number Packaging Price Buy
A8001 5mg $51.4 Buy
A8001 25mg $186 Buy
A8001 100mg $561 Buy
A8001 250mg $1190 Buy
J62056 250mg $766 Buy

Aconitine Chemical Properties,Uses,Production


Aconitum plants (Wu Tou, Ranunculaceae family) have been widely used to treat various diseases, such as rheumatism, knee pain, herpes zoster, scabies, and other disorders in China for thousands of years. It was first described in Shen Nong’s Herbal Classic (the earliest classical work of Chinese herbs). Aconitine is the main active component in Aconitum plants.

Chemical Properties

Off-White Solid

Physical properties

Appearance: solid. Solubility: barely soluble in water and soluble in organic solvents such as chloroform or diethyl ether. Its solubility in water and ethanol are 0.3?mg/mL and 35?mg/mL, respectively. Melting point: 203–204?°C (397–399?°F; 476–477?K). Optical rotation:D+17.3°


Preparations of Aconitum roots are employed in Chinese medicine for analgesic, antirheumatic, and neurological indications. In the Ming Dynasty, Chinese people had extracted the aconitine from the Aconitum plants. Aconitine is synthesized by the Aconitum plants via the terpenoid biosynthesis pathway (MEP chloroplast pathway)


Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and dec reases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In c ultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization. Used in producing heart arrhythmia in experimental anim als.


anesthetic (gastric), antipyretic, and cardiotoxin


Aconitine occurs to the extent of 0.4–0.8%in dried tuberous roots of aconite or monkshood (Aconitum napellus L. and Ranunculaceae) found in India, North America,and Europe. It is used to produce heartarrhythmia in experimental animals and asan antipyretic agent.


Aconitine was previously used as an antipyretic and analgesic. However, the clinical application of aconitine is limited by its high toxicity. Its lethal dose 50% (LD50) for mice is 1.8?mg/kg (orally) and 0.308?mg/kg (intraperitoneally).


ChEBI: A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and b nzoate groups at the 8- and 14-positions respectively.

Health Hazard

Aconitine is among the most toxic alkaloidsknown. Toxic doses are close to therapeuticdoses, and in humans as little as 2 mgmay cause death (Ferry and Vigneau 1983).An oral lethal dose of 28 mg/kg has alsobeen recorded (NIOSH 1986). The toxicsymptoms at low doses may be excitement,drowsiness, and hypermotility. The first signof poisoning from ingestion is a tingling,burning feeling on the lips, mouth, gums,and throat (Hodgson et al. 1988). This isfollowed by nervous disorders, anesthesia,loss of coordination, vertigo, hypersalivation,nausea, vomiting, and diarrhea. Toxic actionsof aconitine are very rapid. The crystallineform of this compound is much more toxicthan the amorphous aconitine. At a lethaldose, death may result from cardiorespiratoryfailure. Procaine may be an effective antidoteagainst aconitine poisoning.


Aconitum was found to have neurotoxin. It could activate tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the nerve action potential and, in turn, blocking the release of neurotransmitters and decreasing the end plate potential at the neuromuscular junction. Aconitine was also found to block norepinephrine reuptake
In the heart, aconitine could induce ventricular tachycardia. In cultured ventricular myocytes, aconitine could induce the appearance of early after depolarization by increasing the duration of the action potential.
Research with mouse nerve-hemidiaphragm muscle preparation found that aconitine at low concentrations (<0.1?μM) could increase the electrically evoked acetylcholine release causing an induced muscle tension. Action potentials were generated more often at this concentration. While at higher concentrations (0.3–3?μM), aconitine could decrease the electrically evoked acetylcholine release, resulting in a decrease in muscle tension. Under the circumstance with high concentration (0.3–3?μM) of aconitine, the sodium-ion channels were constantly activated, and transmission of action potentials was suppressed, leading to the formation of non-excitable target cells or paralysis.

Clinical Use

In clinic, it can be used for treating and alleviating the symptoms caused by arthritis, lumbocrural pain, and herpes zoster; however, it is utilized infrequently in clinical practice due to its obvious side effects
According to a review of different reports of aconite poisoning in human beings, the following clinical features such as neurological, cardiovascular, and gastrointestinal features were observed. The first symptom of aconitine poisoning appeared approximately 20?min–2?h after oral intake, and they were paresthesia, sweating, and nausea, which led to severe vomiting, colicky diarrhea, intense pain, and then paralysis of the skeletal muscles. Following the onset of life-threatening arrhythmia, including ventricular tachycardia and ventricular fibrillation, death finally occurred as a result of respiratory paralysis or cardiac arrest.

Purification Methods

Crystallise it from EtOH, CHCl3 or toluene. [Beilstein 21/6 V 310.]

Aconitine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Apeloa Pharmaceutical Co., Ltd.
+86-0571-87635730 +8615858229168 China 1389 58
Chengdu Biopurify Phytochemicals Ltd. 028-82633397 18602888327 China 2119 60
(1ALPHA,3ALPHA,6ALPHA,14ALPHA,15ALPHA,16BETA)-20-ETHYL-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITANE-3,8,13,14,15-PENTOL 8-ACETATE 14-BENZOATE 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine-4,8,9,11,11a(1H,7H)-pentol, 1-ethyldecahydro-6,10,13-trimethoxy-3-(methoxymethyl)-, 11a-acetate 8-benzoate Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1a,3a,6a,14a,15a,16b)- Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)- 20-Ethyl-1α,6α,16β-trimethoxy-14α-benzoyloxy-4-(methoxymethyl)aconitane-3α,8,13,15α-tetrol 8-acetate 20-Ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)aconitane-3α,8,13,14α,15α-pentol 8-acetate 14-benzoate (1ALPHA,3ALPHA,6ALPHA,14ALPHA,15ALPHA,16BETA)-20-ETHYL-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITANE-3,8,13,14,15-PENTOL 8-ACETATE 14-BENZOATE ACONITANE-3,8,13,14,15-PENTOL,20-ETHYL-1,6,16-TRIMETHOXY-4-(MET 2H-12,3,6a-Ethanylylidene-7,9-Methanonaphth[2,3-b]azocine, aconitane-3,8,13,14,15-pentol deriv ACONITINE(P) (1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-triMethoxy-4-(MethoxyMethyl)aconitane-3,8,13,14,15-pentol 8-Acetate 14-Benzoate Aconitie ACETYLBENZOYLACONINE ACONITINE ACONITANE ACONITANE-3,8,13,14,15-PENTOL,20-ETHYL-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)-,8-ACETATE14-BENZOATE,(1ALPHA,3ALPHA,6ALPHA,14ALPHA,15ALPHA,16BETA)- aconitincristallisat aconitine(crystalline) ACONITINE TETRODOTOXIN-SENSITIV ACONITINE, CRYSTALLIZED ACONITINE 98% BY HPLC ACONITANE-3,8,13,14,15-PENTOL,20-ETHYL-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)-,8-ACETATE14-BENZOATE,(1,3,6,14,15,16)-, Aconitine std. AconitineStandard ACONITINE(SH) ADYNERIN(P) 14-benzoate,(1,3,6,14,15,16β)- Conitane-3,8,13,14,15-pentol,20-ethyl-1,6,16- trimethoxy-4-(methoxymethyl)-,8-acetate Aconitine,Acetylbenzoylaconine Aconitine 302-27-2 Aconitine,HPLC≥98% Acotinine ACONITIN 302-27-2 C34H47NO11 C34H42O11NC2H5 C34H477NO11 Voltage-gated Ion Channels Sodium Channel Modulators Monovalent Ion Channels Ion Channels Complex Molecules Asymmetric Synthesis Cell Biology Chiral Building Blocks Cell Signaling and Neuroscience BioChemical Amiloride and Derivatives Alkaloids Amines Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals chemical reagent pharmaceutical intermediate phytochemical