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Citicoline sodium

Description Application Mechanism of action
Citicoline sodium
Citicoline sodium structure
CAS No.
33818-15-4
Chemical Name:
Citicoline sodium
Synonyms
GDPC;Logan;Brassel;Cidifos;Gerolin;Sinkron;Cebroton;CDP .2Na;5′-CDP,Na;Acticolin
CBNumber:
CB1343597
Molecular Formula:
C14H27N4NaO11P2
Formula Weight:
512.32
MOL File:
33818-15-4.mol

Citicoline sodium Properties

Melting point:
259-268°C (dec.)
alpha 
D20 +12.5° (c = 1.0 in H2O)
storage temp. 
-20°C
solubility 
H2O: 100mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (100 mg/ml).
λmax
280nm(HCl aq.)(lit.)
Merck 
13,2343
BRN 
4110040
InChIKey
YWAFNFGRBBBSPD-OCMLZEEQSA-M
CAS DataBase Reference
33818-15-4
FDA UNII
7XQ5AKD9YD
NCI Drug Dictionary
citicoline
ATC code
N06BX06
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  3
3-10-21
HS Code  29349990

Citicoline sodium price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 34015 Citicoline sodium salt hydrate VETRANAL?, analytical standard 33818-15-4 100 mg $92.7 2021-12-16 Buy
Sigma-Aldrich 30290 Cytidine 5′-diphosphocholine sodium salt hydrate ≥99.0% (HPLC) 33818-15-4 250mg $199 2021-12-16 Buy
Sigma-Aldrich 30290 Cytidine 5′-diphosphocholine sodium salt hydrate ≥99.0% (HPLC) 33818-15-4 1g $439 2021-12-16 Buy
TCI Chemical C3445 Cytidine 5'-Diphosphocholine Sodium Salt >98.0%(HPLC) 33818-15-4 1g $18 2021-12-16 Buy
TCI Chemical C3445 Cytidine 5'-Diphosphocholine Sodium Salt >98.0%(HPLC) 33818-15-4 5g $53 2021-12-16 Buy

Citicoline sodium Chemical Properties,Uses,Production

Description

Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. Takeda pharmaceutical company in Japan developed and produced it in 1961. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects.

Application

Mechanism of action

Citicoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory.

Chemical Properties

White Solid

Uses

Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.

Uses

Cytidine 5′-diphosphate (CDP) is used as a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6) to produce CTP in support ofDNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.

Uses

Cytidine-5'-diphosphocholine sodium salt hydrate acts as a neuroprotective agent in situations of hypoxia and ischemia. It is used as biosynthetic intermediate of membrane phospholipids. It is a cerebral vasodilator and inhibits PLA2 activation.

Application

Citicoline (CDP-choline) is an essential intermediate in the synthesis of the major phospholipid of the cell membranes, phosphatidylcholine (PtdCho). It increases plasma adrenocorticotropic hormone (ACTH) levels and potentiates serum thyrotrophin (TSH) levels by activating the central cholinergic system.
Citicoline Sodium is used to treat age-related memory loss, cerebrovascular diseases such as stroke, dementia, as well as head trauma. Research has shown that it increases a chemical called phosphatidylcholine which is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured. Citicoline Sodium is also said to help with weight management when used as a dietary supplement.

brand name

CerAxon (Interneuron).

Safety

There are two forms of citicoline: citicoline sodium and citicoline free-base. Citicoline sodium is the form that is approved as a prescription medication in some European countries and throughout Asia. Citicoline free-base is the form that is available as a dietary supplement and food/beverage ingredient in the United States. In Europe, citicoline is approved as a Novel Food ingredient and is authorized to be used in food supplements up to 500 mg per day. It is also authorized to be used for Food for Special Medical Purposes (FSMPs) in amounts of 250 mg/serving and up to 1,000 mg per day.
Citicoline free-base is produced in Japan by Kyowa Hakko Bio Co. Ltd. under the brand name of Cognizin. Cognizin is considered to be safe and received self-designated Generally Recognized As Safe (GRAS) status in 2009. In Europe, citicoline was approved as a Novel Food ingredient in 2014. Whereas most companies produce citicoline synthetically, Cognizin is produced using a patented, natural fermentation process. It is vegetarian and allergen-free. Kyowa Hakko manufactures and supplies Cognizin as a raw ingredient to many manufacturers around the world.

Metabolism

Citicoline can be administered orally, intramuscularly, or intravenously. Oral administration is most common because its bioavailability is approximately 92%. After oral ingestion, citicoline is hydrolyzed in the small intestine and liver into 2 major metabolites: cytidine and choline.
Cytidine and choline enter the systemic circulation, where cytidine is further metabolized into uridine. Both uridine and free choline cross the blood-brain barrier. In the central nervous system, uridine is converted to cytidine triphosphate, choline is converted to phosphocholine, and the 2 combine to resynthesize CDP-choline.

Citicoline sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Citicoline sodium Suppliers

Global( 366)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9467 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 175 58
Hangzhou Weitai Biological Pharmaceutical Co.,Ltd.
+8613282012786
sales@weitai-pharmaceutical.com CHINA 43 58
Jinan Honest Pharm Co., Ltd
+86-15318812076
sale@jnhonestpharm.com; honestpharm@163.com; CHINA 290 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9115 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 136 58

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View Lastest Price from Citicoline sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-18 Citicoline sodium
33818-15-4
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-14 Citicoline sodium
33818-15-4
US $10.00 / g/Bag 10g 99 100KG Wuhan Demeikai Biotechnology Co., Ltd
2021-12-08 Citicoline Sodium (CDPC)
33818-15-4
US $0.00 / g 10g ≥99%(Excellent grade) 2tons Hangzhou Weitai Biological Pharmaceutical Co.,Ltd.

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