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Citicoline sodium

CAS No.
33818-15-4
Chemical Name:
Citicoline sodium
Synonyms
CITICOLINE;CITICOLINE SODIUM SALT;CITICOLINE MONOSODIUM SALT;GDPC;Logan;Brassel;Cidifos;Gerolin;Sinkron;Cebroton
CBNumber:
CB1343597
Molecular Formula:
C14H26N4O11P2.Na
Molecular Weight:
511.31
MDL Number:
MFCD00037486
MOL File:
33818-15-4.mol
MSDS File:
SDS
Last updated:2024-01-22 09:45:43

Citicoline sodium Properties

Melting point 259-268°C (dec.)
alpha D20 +12.5° (c = 1.0 in H2O)
storage temp. -20°C
solubility H2O: 100mg/mL
form solid
color white
Water Solubility Soluble in water (100 mg/ml).
λmax 280nm(HCl aq.)(lit.)
Merck 13,2343
BRN 4110040
InChIKey YWAFNFGRBBBSPD-OCMLZEEQSA-M
CAS DataBase Reference 33818-15-4
FDA UNII 7XQ5AKD9YD
NCI Drug Dictionary citicoline
ATC code N06BX06

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Safety Statements  24/25
WGK Germany  3
3-10-21
HS Code  29349990

Citicoline sodium price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 34015 Citicoline sodium salt hydrate VETRANAL?, analytical standard 33818-15-4 100mg $116 2024-03-01 Buy
Sigma-Aldrich 30290 Cytidine 5′-diphosphocholine sodium salt hydrate ≥99.0% (HPLC) 33818-15-4 250mg $250 2024-03-01 Buy
Sigma-Aldrich 30290 Cytidine 5′-diphosphocholine sodium salt hydrate ≥99.0% (HPLC) 33818-15-4 1g $550 2024-03-01 Buy
TCI Chemical C3445 Cytidine 5'-Diphosphocholine Sodium Salt >98.0%(HPLC) 33818-15-4 1g $19 2024-03-01 Buy
TCI Chemical C3445 Cytidine 5'-Diphosphocholine Sodium Salt >98.0%(HPLC) 33818-15-4 5g $57 2024-03-01 Buy
Product number Packaging Price Buy
34015 100mg $116 Buy
30290 250mg $250 Buy
30290 1g $550 Buy
C3445 1g $19 Buy
C3445 5g $57 Buy

Citicoline sodium Chemical Properties,Uses,Production

Description

Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. Takeda pharmaceutical company in Japan developed and produced it in 1961. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects.

Application

  • Central nervous system medication.
  • Coenzyme. For acute traumatic brain injury and brain surgery consciousness. Acute brain injury and brain surgery after a disturbance of consciousness, paralysis due to stroke can gradually restore the function of the limbs, it can also be used for functions and other central nervous system disorders of consciousness caused by acute injury, and also for ischemic cerebrovascular disease and vascular dementia.

Mechanism of action

Citicoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory.

Chemical Properties

White Solid

Uses

Cytidine-5'-diphosphocholine sodium salt hydrate acts as a neuroprotective agent in situations of hypoxia and ischemia. It is used as biosynthetic intermediate of membrane phospholipids. It is a cerebral vasodilator and inhibits PLA2 activation.

Uses

Cytidine 5′-diphosphate (CDP) is used as a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6) to produce CTP in support ofDNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.

Uses

Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.

Application

Citicoline (CDP-choline) is an essential intermediate in the synthesis of the major phospholipid of the cell membranes, phosphatidylcholine (PtdCho). It increases plasma adrenocorticotropic hormone (ACTH) levels and potentiates serum thyrotrophin (TSH) levels by activating the central cholinergic system.
Citicoline Sodium is used to treat age-related memory loss, cerebrovascular diseases such as stroke, dementia, as well as head trauma. Research has shown that it increases a chemical called phosphatidylcholine which is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured. Citicoline Sodium is also said to help with weight management when used as a dietary supplement.

brand name

CerAxon (Interneuron).

General Description

Cytidine 5′-diphosphocholine (CDP-choline) contains cytidine and choline linked via a diphosphate bridge.

Biochem/physiol Actions

Cytidine 5′-diphosphocholine (CDP-choline) plays an important role in the synthesis of phosphatidylcholine. It is also involved in the biosynthesis of acetylcholine, a neurotransmitter. CDP-choline has therapeutic effects against hypoxia, cerebral ischemia and traumatic brain injury. It also exhibits therapeutic effects against learning and memory disorders, drug addiction and Alzheimer′s and Parkinson′s diseases.

Safety

There are two forms of citicoline: citicoline sodium and citicoline free-base. Citicoline sodium is the form that is approved as a prescription medication in some European countries and throughout Asia. Citicoline free-base is the form that is available as a dietary supplement and food/beverage ingredient in the United States. In Europe, citicoline is approved as a Novel Food ingredient and is authorized to be used in food supplements up to 500 mg per day. It is also authorized to be used for Food for Special Medical Purposes (FSMPs) in amounts of 250 mg/serving and up to 1,000 mg per day.
Citicoline free-base is produced in Japan by Kyowa Hakko Bio Co. Ltd. under the brand name of Cognizin. Cognizin is considered to be safe and received self-designated Generally Recognized As Safe (GRAS) status in 2009. In Europe, citicoline was approved as a Novel Food ingredient in 2014. Whereas most companies produce citicoline synthetically, Cognizin is produced using a patented, natural fermentation process. It is vegetarian and allergen-free. Kyowa Hakko manufactures and supplies Cognizin as a raw ingredient to many manufacturers around the world.

Metabolism

Citicoline can be administered orally, intramuscularly, or intravenously. Oral administration is most common because its bioavailability is approximately 92%. After oral ingestion, citicoline is hydrolyzed in the small intestine and liver into 2 major metabolites: cytidine and choline.
Cytidine and choline enter the systemic circulation, where cytidine is further metabolized into uridine. Both uridine and free choline cross the blood-brain barrier. In the central nervous system, uridine is converted to cytidine triphosphate, choline is converted to phosphocholine, and the 2 combine to resynthesize CDP-choline.

987-78-0
33818-15-4
Synthesis of Citicoline sodium from CYTIDINE 5'-DIPHOSPHOCHOLINE

Citicoline sodium Preparation Products And Raw materials

Global( 505)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Weitai Biological Pharmaceutical Co.,Ltd.
+8613282012786 sales@weitai-pharmaceutical.com China 61 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118 xie@china-sinoway.com China 998 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Xiamen Wonderful Bio Technology Co., Ltd.
+8613043004613 Sara@xmwonderfulbio.com China 305 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55

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View Lastest Price from Citicoline sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Citicoline Sodium pictures 2024-03-19 Citicoline Sodium
33818-15-4
US $220.00-160.00 / Kg/Bag 1Kg/Bag 99% up / CP2010 / GMP 20 tons Sinoway Industrial co., ltd.
Citicoline sodium pictures 2024-03-16 Citicoline sodium
33818-15-4
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Citicoline sodium pictures 2024-01-20 Citicoline sodium
33818-15-4
US $9.90-9.90 / g 5g 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz 100kg Wuhan Biocar Pharmacy Co., Ltd.
  • Citicoline Sodium pictures
  • Citicoline Sodium
    33818-15-4
  • US $220.00-160.00 / Kg/Bag
  • 99% up / CP2010 / GMP
  • Sinoway Industrial co., ltd.
  • Citicoline sodium pictures
  • Citicoline sodium
    33818-15-4
  • US $9.90-9.90 / g
  • 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
  • Wuhan Biocar Pharmacy Co., Ltd.
P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT CYTIDINE-5'-DIPHOSPHOCHOLINE, NA CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE CITICOLINE SODIUM CDP-CHOLINE MONOSODIUM SALT CDP-CHOLINE, NA CDP-CHOLINE, SODIUM SALT CDP-COLINE Cytidine 5'-(trihydrogen diphosphate), mono[2-(trimethylammonio)ethyl] ester, hydroxide, inner salt, monosodium salt Citicoline Sodium, Vetranal Cdp-Choline(CytidineDiphosphateCholine) cytidin-5'-diphosphocholin sodium salt hydrate CDP-CHOLINE, SODIUM Cytidine 5'-Diphosphocholine Sodium Salt CDP-choline.Na CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE 99.0% Cytidine5'-(trihydrogen diphosphate), P'-[2-(triMethylaMMonio)ethyl] ester, inner salt,sodiuM salt (1:1) Citicoline sod Cytidine 5′-diphosphocholine sodium salt hydrate CDP-coline Citicoline sodium cytidine 5′-(tri-hydro-gen di-phos-phate) inner salt monosodium P′-[2-(Trimethylammonio)-ethyl]-ester Cytidine 5'-diphosphocholine, Sodium Salt (CDP-choline) CDP-choline-Na, CDP-coline, Citicoline sodium, Cytidine 5μ-diphosphocholine dihydrate sodium salt, Pμ-[2-(Trimethylammonio)ethyl]ester cytidine 5μ-(trihydrogen diphosphate) inner salt monosodium CDP-choline-Na, CDP-coline, Citicoline sodium, Pμ-[2-(Trimethylammonio)ethyl]ester cytidine 5μ-(trihydrogen diphosphate) inner salt monosodium Cytidine 5μ-diphosphocholine dihydrate sodium salt Cytidine 5′-diphosphocholine sodium salt dihydrate,CDP-choline-Na, CDP-coline, Citicoline sodium, P′-[2-(Trimethylammonio)-ethyl]-ester cytidine 5′-(tri-hydro-gen di-phos-phate) inner salt monosodium CITICOLINE SODIUM (CDP-COLINE/ CITIDINE (5I)-DIPHOSPHOCHOLINE) Cytidine 5'-diphosphoric acid α-sodium β-[2-(trimethylammonio)ethyl] ester salt Cytidine-5'- 5′-CDP,Na Acticolin Brassel Cebroton Cidifos Cytidine 5'-(Trihydrogen Diphosphate) P'-[2-(TriMethylaMMonio)ethyl] Ester Inner Salt SodiuM Salt Flussorex Gerolin IP 302 SodiuM Logan Neurotron Sinkron Citicoline SodiuM API CDPC (Citicoline MonosodiuM salt) Citicoline sodiuM salt hydrate Cytidoline sodium salt Citicoline Sodium Salt (CDP-Choline) 5′-Diphosphocholine Sodium Salt GDPC sodium [[(2S,3R,4S,5S)-5-(4-amino-2-oxo-1-pyrimidinyl)-3,4-dihydroxy-2-oxolanyl]methoxy-oxidophosphoryl] 2-(trimethylammonio)ethyl phosphate Citicoline Sodium (2 x 350 mg) CDP .2Na Cytosine sodium Citicoline sodium USP/EP/BP Citicoline Sodium CAS No.?33818-15-4?99% Powder Used for Neuroprotective