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2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

CAS No.
4065-45-6
Chemical Name:
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Synonyms
BENZOPHENONE-4;BP-4;SULISOBENZONE;uvinul;UV-284;HMBS;5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULFONIC ACID;BIP1;2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONIC ACID;ms40
CBNumber:
CB1359279
Molecular Formula:
C14H12O6S
Molecular Weight:
308.31
MDL Number:
MFCD00024962
MOL File:
4065-45-6.mol
MSDS File:
SDS
Last updated:2023-12-22 17:53:22

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Properties

Melting point 170 °C
Boiling point 0°C
Density 1.4574 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5300 (estimate)
Flash point 0°C
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka -0.70±0.50(Predicted)
color White to Off-White
Water Solubility 300.92g/L at 25℃
Merck 14,8983
BRN 2889165
InChIKey CXVGEDCSTKKODG-UHFFFAOYSA-N
LogP 0.515 at 25℃
CAS DataBase Reference 4065-45-6(CAS DataBase Reference)
EWG's Food Scores 3
FDA UNII 1W6L629B4K
EPA Substance Registry System Sulisobenzone (4065-45-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H412
Precautionary statements  P264-P273-P280-P302+P352-P305+P351+P338-P332+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39-36/37/39-27
WGK Germany  1
RTECS  DB5044300
TSCA  Yes
HS Code  29147000
NFPA 704
0
2 0

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1642100 Sulisobenzone United States Pharmacopeia (USP) Reference Standard 4065-45-6 500mg $483 2024-03-01 Buy
Sigma-Aldrich 09649 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid ≥97.0% (HPLC) 4065-45-6 10g $114 2024-03-01 Buy
TCI Chemical H0466 2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol) >98.0%(T) 4065-45-6 25g $49 2024-03-01 Buy
TCI Chemical H0466 2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol) >98.0%(T) 4065-45-6 500g $334 2024-03-01 Buy
Alfa Aesar L12912 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid hydrate, tech. 85%, may cont. up to 10% 2-propanol 4065-45-6 10g $66.65 2024-03-01 Buy
Product number Packaging Price Buy
1642100 500mg $483 Buy
09649 10g $114 Buy
H0466 25g $49 Buy
H0466 500g $334 Buy
L12912 10g $66.65 Buy

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemical Properties,Uses,Production

Chemical Properties

white to yellowish powder

Originator

Uval,Dome,US,1965

Uses

sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical.

Uses

Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos.

Uses

ultraviolet screen

Uses

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure.

Definition

ChEBI: Sulisobenzone is a member of benzophenones.

Manufacturing Process

663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.

brand name

Sungard (Bayer).

Therapeutic Function

Sunscreen agent

General Description

Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.

Flammability and Explosibility

Non flammable

Contact allergens

BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen.

131-57-7
4065-45-6
Synthesis of 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid from Oxybenzone

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 511)Suppliers
Supplier Tel Email Country ProdList Advantage
Qingdao Truelight functional Material Technology Co., Ltd.
+86-13573844393 songjames@truelightchem.com China 219 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
QINGDAO JADE NEW MATERIAL TECNOLOGY CO.,LTD
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0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
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+8617756083858 daisy@anhuiruihan.com China 994 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 7378 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 15371 58

View Lastest Price from 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ultraviolet absorber UV-284 pictures 2024-04-17 Ultraviolet absorber UV-284
4065-45-6
US $32.00 / kg 1kg 99% 100mt Jinan Finer Chemical Co., Ltd
UV ABSORBER TRUELICHT BP-4 pictures 2024-04-16 UV ABSORBER TRUELICHT BP-4
4065-45-6
US $0.00 / KG 1KG 98.0% 1000tons Qingdao Truelight functional Material Technology Co., Ltd.
 Benzophenone-4 pictures 2024-04-16 Benzophenone-4
4065-45-6
US $40.00-30.00 / kg 1kg 99% 5000kg/week Hebei Yime New Material Technology Co., Ltd.
  •  Benzophenone-4 pictures
  • Benzophenone-4
    4065-45-6
  • US $40.00-30.00 / kg
  • 99%
  • Hebei Yime New Material Technology Co., Ltd.
Uvistat 1121 UV ABSORBER HMBS TIMTEC-BB SBB002961 spectra-sorb uv 284 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID HYDRATE 2-HYDROXY-4-METHOXY-5-SULFOBENZOPHENONE 2-HYDROXY-4-METHOXY-5-SULFONYLBENZOPHENONE 2-Benzoyl-5-methoxy-1-phenol-4-sulfonic acid 2-benzoyl-5-methoxy-1-phenol-4-sulfonicaci 2-Hydroxy-4-Methoxy-5-Benzophenonesulfonicacid 5-benzoyl-4-hydroxy-2-methoxy-benzenesulfonicaci 2-Hydoxy-4-methoxybenzophenone-5-sulfonic acid Sulisobenzone (500 mg) 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic Acid Sulisobenzone Benzenesulfonicacid,5-benzoyl-4-hydroxy-2-methoxy- Benzophenone-4,sulisobenzone ms40 Samsorb-4MS seesorb101s syntase230 uval UvinualMS-40 uvinulms40 UVSOB340 2-Hydroxy-4-Methoxy-5-Sulffonylbenzophenone(BP-4) 2-Hydroxy-4-Methoxy-5-Sulfo- UV absorber UV BP-4 Hydroxy-4-Methoxybenzophenone-5-sulfonic Acid 5-Benzoyl-4-hydroxy-2-Methoxybenzenesulfonic acid >=97.0% (HPLC) 2- hydroxy-4-Methoxy -5-sulfonic acid twoBenzophenone 2 - hydroxy - 4 - Methoxy - 5 - sulphonic acid diphenyl ketone 2 - hydroxy - 4 - Methoxy diphenyl ketone - 5 - sulphonic acid 5-Benzoyl-4-hy Anti-BIK, N-Terminal antibody produced in rabbit Apoptosis inducer NBK Bcl-2 interacting killer BIKLK 2-Hydroxy-4-Methoxy-5-sulfonylbenzophenone (Benzophenone-4) 5-Benzoyl-4-hydroxy-2-methoxybenzene sulfonic aid 2-HYDROXY-4-METHOXY-5-SULFONYLBENZOPHENONE(BP-4) 2-Hydroxy-4-Methoxy-5-SulphoicBenzophenoneUv284Bp4A2093 BENZOPHENONE-4 (UV 284) BENZENESULPHONICACID,5-BENZOYL-4-HYDROXY-2-METHOXY- 2-HYDROXY-4-METHOXY-5-SULPHOBENZOPHENONE Sulisobenzon 2-Hydroxy-4-methoxybenzophenone-5-sulfonicAicd 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID HYDRATE: TECH., 85%, MAY CONT. UP TO 10% 2-PROPANOL 2-benzoyl-5-methoxy-1-phenol-4-sulphonic acid 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID, 99+% 4-BENZOPHENONE 2-Hydroxy-4-methoxybenzophenone-5-sulphonic acid hydrate UV Absorber BP-4 HMBS, Sulisobenzone Ultraviolet absorbent UV-284 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid, HMBS, Sulisobenzone ultraxiolet absorbent D-49 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid,98%