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L-Histidine hydrochloride monohydrate

L-Histidine hydrochloride monohydrate structure

CAS No.: 5934-29-2

Chemical Name:: L-Histidine hydrochloride monohydrate

Synonyms: 15N3, 98%);L-HIS HCL H2O;Histidine (H);HISTIDINE HCL;L-His.H2o.HCl;H-His-OH¤HCl¤H;L-HISTIDINEHCL;H-HIS-OH HCL H2O;L-His-OH·HCl·H2O;HISTIDINE HCL H2O

CBNumber:: CB1369616

Molecular Formula:: C6H12ClN3O3

Molecular Weight:: 209.63

MDL Number:: MFCD00151027

MOL File:: 5934-29-2.mol

MSDS File:: SDS

Last updated:2026-01-20 10:51:09

Product description	Number	Pack Size	Price
L-Histidine monohydrochloride monohydrate from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%	H5659	25G	$55.9
L-Histidine monohydrochloride monohydrate from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%	H5659	100G	$143
L-Histidine monohydrochloride monohydrate from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%	H5659	1KG	$876
Histidine hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard	H0755000	100 mg	$236
(S)-(+)-Histidine hydrochloride monohydrate for synthesis	8.16005	25g	$39.1
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L-Histidine hydrochloride monohydrate Properties

Melting point	254 °C (dec.)(lit.)
alpha	9.9 º (c=11, 6 N HCl)
Density	1.49 g/cm3
bulk density	770kg/m3
vapor pressure	<1 hPa (20 °C)
storage temp.	Store below +30°C.
solubility	H₂O: 100 mg/mL
form	Solid
color	White
PH	3.5-4.5 (100g/l, H2O, 20℃)
PH Range	3 - 4 at 105 g/l at 25 °C
Odor	odorless
biological source	non-animal source
optical activity	[α]20/D +9.5±0.5°, c = 5% in 5 M HCl
Water Solubility	169.9 g/L (20 ºC)
Merck	14,4720
BRN	4168261
Cosmetics Ingredients Functions	SKIN CONDITIONING HAIR CONDITIONING
Cosmetic Ingredient Review (CIR)	L-Histidine hydrochloride monohydrate (5934-29-2)
InChI	1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1
InChIKey	CMXXUDSWGMGYLZ-XRIGFGBMSA-N
SMILES	O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O
LogP	-3.32 at 25℃
CAS DataBase Reference	5934-29-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	X573657P6P
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P264-P280-P305+P351+P338-P337+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

22-24/25-36/37-26

WGK Germany

RTECS

MS3119000

TSCA

Yes

HS Code

29332990

Storage Class

11 - Combustible Solids

NFPA 704

	0
1		0

L-Histidine hydrochloride monohydrate price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H5659	L-Histidine monohydrochloride monohydrate from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%	5934-29-2	25G	$55.9	2025-07-31	Buy
Sigma-Aldrich	H5659	L-Histidine monohydrochloride monohydrate from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%	5934-29-2	100G	$143	2025-07-31	Buy
Sigma-Aldrich	H5659	L-Histidine monohydrochloride monohydrate from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%	5934-29-2	1KG	$876	2025-07-31	Buy
Sigma-Aldrich	H0755000	Histidine hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard	5934-29-2	100 mg	$236	2025-07-31	Buy
Sigma-Aldrich	8.16005	(S)-(+)-Histidine hydrochloride monohydrate for synthesis	5934-29-2	25g	$39.1	2025-07-31	Buy

Product number	Packaging	Price	Buy
H5659	25G	$55.9	Buy
H5659	100G	$143	Buy
H5659	1KG	$876	Buy
H0755000	100 mg	$236	Buy
8.16005	25g	$39.1	Buy

L-Histidine hydrochloride monohydrate Chemical Properties,Uses,Production

Chemical Properties

white crystals or cryst. or granular powder

Uses

L-Histidine Hydrochloride Monohydrate can be used as AhR activators to treat gluten-induced gastrointestinal diseases. It can also be used for hair coloring method.

Uses

L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis.

Uses

L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.

General Description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^? Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^? portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Biochem/physiol Actions

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.

Purification Methods

Crystallise the monohydrochloride from aqueous EtOH or 60% aqueous EtOH (m 259odec). Alternatively dissolve 10g in 50mL of H2O, decolourise with Norite, filter, evaporate it in a vacuum to a syrup, cool to room temperature, add 95% EtOH with stirring until slightly turbid, scratch the sides of the vessel until crystals form, then add slowly 40mL of EtOH and keep at 0o overnight, filter the solid off, wash it several times with EtOH and dry it in a vacuum. [Cox J Biol Chem 78 475 1929, Cox et al. J Biol Chem 81 73 1929, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1972, 2098 1961, Beilstein 25 II 407, 25 III/IV 4346.]

L-Histidine hydrochloride monohydrate synthesis

Synthesis of L-Histidine hydrochloride monohydrate from L-Histidine

L-Histidine hydrochloride monohydrate Preparation Products And Raw materials

Raw materials

HEMOGLOBIN Soy bean Isoflavone Isoflavone 10-40% L-Lysine Hydrolyzate Ion exchange resin column

Preparation Products

N-Boc-L-Histidine

L-Histidine hydrochloride monohydrate Suppliers

Global( 594)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from L-Histidine hydrochloride monohydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-23	L-Histidine hydrochloride monohydrate 5934-29-2	US $0.00 / KG	1KG	99.0%	5000kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-01-20	L-Histidine monohydrochloride monohydrat 5934-29-2	US $39.00 / mg		99.87%	10g	TargetMol Chemicals Inc.
2025-05-23	L-Histidine hydrochloride monohydrate 5934-29-2	US $45.00 / kg	1kg	99%	20 tons	Hebei Zhuanglai Chemical Trading Co Ltd

L-Histidine hydrochloride monohydrate
5934-29-2
US $0.00 / KG
99.0%
WUHAN FORTUNA CHEMICAL CO., LTD

L-Histidine monohydrochloride monohydrat
5934-29-2
US $39.00 / mg
99.87%
TargetMol Chemicals Inc.

L-Histidine hydrochloride monohydrate
5934-29-2
US $45.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

L-Histidine hydrochloride monohydrate Spectrum

L-Histidine hydrochloride monohydrate(5934-29-2)¹HNMR L-Histidine hydrochloride monohydrate(5934-29-2)FT-IR L-Histidine hydrochloride monohydrate(5934-29-2)IR L-Histidine hydrochloride monohydrate(5934-29-2)Raman

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L-ALPHA-AMINO-4(OR 5)-IMIDAZOLEPROPIONIC ACID MONOHYDROCHLORIDE, MONOHYDRATE L-ALPHA-AMINO-BETA-(4-IMIDAZOLYL)PROPIONIC ACID MONOHYDROCHLORIDE L-HIS HCL H2O L-HISTIDINE MONOHYDROCHLORIDE H2O L-(+)-HISTIDINE HYDROCHLORIDE MONOHYDRATE L-HISTIDINE HYDROCHLORIDE MONOHYDRATE L-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE L-HISTIDINE HCL H2O L-HISTIDINE HCL MONOHYDRATE L-HISTINE HYDROCHLORIDE MONOHYDRATE L-HISTINE HCL MONOHYDRATE H-HIS-OH HCL H2O (S)-(+)-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE Histidinehydrochloridemonohydrate l-histidinehcl,histidinehcl L-Histidinehydrochloride,mono L-Histidinehydrochloridehydrate monohydrochloride,monohydrate,l-histidin monohydrochloride,monohydrate,L-Histidine L-Histidine-d3 HCl H2O (S)-(+)-HISTIDINE HYDROCHLORIDE MONOHYDR Histidine (H) Histidine Solution (H) GUANIDINE:HCL (13C, 99% 15N3, 98%) L-HISTIDINE:HCL:H2O (D5, 98% Histidine (H) Solution, 100ppm L-Histidine monohydrochloride monohydrate Vetec(TM) reagent grade, 99% PHENOL/CHLOROFORM/IAA 1 PHASE BIOTECH GR L-HISTIDINE:HCL:H2O (<5% D) (13C6) H-His-OH.HCl monohydrate H-His-OH¤HCl¤H L-His-OH·HCl·H2O L-Histidine hydrochloride monohydrate98.5-101.0% (Titration: anhydrous basis) L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride L-Histidine Hydrochloride Monohydrate H-His-OH.HCl (S)-(+)-Histidine hydrochloride monohydrate for synthesis L(+)-Histidine monohydrochloride-1-hydrate HISTIDINE HCL H2O L-HistidineMonohydrochlorideForBiochemistry HISTIDINE HCL l-α-amino-β-(4-imidazolyl)propionic acid monohydrochloride L-HISTIDINEMONOHYDROCHLORIDE,MONOHYDRATE,FCC L-HISTIDINEHCL Histidine Hydrochloride, L-, 1-Hydrate L-(+)-Histidine hydrochloride monohydrate, 98+% L-HISTIDINE HYDROCHLORIDE extrapure CHR L-Histidine monohydrate monohydrochloride L-Histidine HCL Mono (2S)-2-Amino-3-(3H-imidazol-4-yl)propanoic acid hydrate hydrochloride L-Histidine hydrochl L-HISTIDINE:HCL:H20 L-HISTIDINE:HCL:H2O (<5% D) L-Histidine hydrochloride Monohydrate, 98% 100GR L-Histidine hydrochloride Monohydrate, 98% 25GR (S)-2-AMino-3-(1H-iMidazol-4-yl)propanoic acid hydrochloride hydrate L-Histidine monohydrochloride monohydrate ,99% (S)-(+)-Histidine hydrochloride monohydrate L-Histidine monohydrochloride monohydrat