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Tetracaine hydrochloride

Application Side Effects
Tetracaine hydrochloride
Tetracaine hydrochloride structure
Chemical Name:
Tetracaine hydrochloride
Molecular Formula:
Formula Weight:
MOL File:

Tetracaine hydrochloride Properties

Melting point:
1.1279 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
alcohol: solublesoluble 40 parts of solvent
8.39(at 25℃)
Water Solubility 
Soluble in water at 50mg/ml
CAS DataBase Reference
136-47-0(CAS DataBase Reference)
EPA Substance Registry System
Tetracaine hydrochloride (136-47-0)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H301-H317-H319-H334
Precautionary statements  P261-P284-P301+P310a-P501a-P280-P305+P351+P338-P301+P310-P264-P270-P301+P310+P330-P305+P351+P338+P337+P313-P405-P501
Hazard Codes  T
Risk Statements  25-36-43-42/43
Safety Statements  26-36/37-45-36/37/39-22-53
RIDADR  2811
WGK Germany  3
RTECS  DG4900000
HazardClass  6.1
PackingGroup  III
HS Code  29224999
Toxicity LD50 i.p. in mice: 70 mg/kg (Dawes); also reported as LD50 in female mice (mg/kg): 13 i.v.; 35 s.c. (Bopp)

Tetracaine hydrochloride price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1129 Tetracaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 136-47-0 1g $72.8 2021-12-16 Buy
Sigma-Aldrich T0500000 Tetracaine hydrochloride European Pharmacopoeia (EP) Reference Standard 136-47-0 $190 2021-12-16 Buy
Sigma-Aldrich 1650006 Tetracaine hydrochloride United States Pharmacopeia (USP) Reference Standard 136-47-0 200mg $366 2021-12-16 Buy
TCI Chemical T1688 Tetracaine Hydrochloride >98.0%(HPLC)(T) 136-47-0 5g $31 2021-12-16 Buy
TCI Chemical T1688 Tetracaine Hydrochloride >98.0%(HPLC)(T) 136-47-0 25g $78 2021-12-16 Buy

Tetracaine hydrochloride Chemical Properties,Uses,Production


Tetracaine hydrochloride is also known as ropivacaine hydrochloride, pantocaine, pantocaine and four ropivacaine hydrochloride. It is easily soluble in water and ethanol, but insoluble in ether, benzene. Tetracaine hydrochloride is a local anesthetic with long-acting ester. In addition, procaine is widely used in clinical, but because of its poor permeability and poor narcotic performance, a small tetracaine was found in 1930 found.
Tetracaine hydrochloride can be used for topical anesthesia, and 0.05%-0.1% tetracaine hydrochloride can provide long-term and good effect of surface anesthesia. Meanwhile, tetracaine hydrochloride is still widely used in ophthalmic surface anesthesia, which has a long time for surface anesthesia and sensory resistance.

Side Effects

Common side effects include a brief period of burning at the site of use.Allergic reactions may uncommonly occur. Long term use is generally not recommended as it may slow healing of the eye. It is unclear if use during pregnancy is safe for the baby. Tetracaine hydrochloride is in the ester-type local anesthetic family of medications. It works by blocking the sending of nerve impulses.

Chemical Properties

White Solid


Anestesia topica,Miro


anesthetic (local)


Tetracaine hydrochloride is used as topical and local anesthetic.


Tetracaine hydrochloride is a local anesthetic used topically in opthalmology.

Manufacturing Process

4-Butylaminobenzoic acid is produced by boiling an aqueous solution of the sodium salt of 4-aminobenzoic acid with n-butyl-bromide. It forms a colorless crystalline powder melting at 153-154°C.
Equimolecular quantities of 4-butylaminobenzoic acid and the hydrochloride of β-dimethylaminoethanol are suspended in 10 times their joint weight of toluene. The mixture is saturated with hydrochloric acid gas and heated in an oil bath at about 150°C while a current of hydrochloric acid, gas is slowly passed through the mixture so that toluene slowly distils. Along with toluene the water produced by the esterification distils. After heating for about 10 hours the mixture is cooled and water is added until the salt is dissolved. The layer of toluene is separated and the ester base precipitated from the aqueous solution by means of a solution of sodium carbonate. By dissolving the base in ether, drying the ether solution separated over potassium carbonate and adding alcoholic hydrochloric acid, to the solution until it is neutral to litmus, the monohydrochloride is obtained in the form of a colorless crystalline powder which, when recrystallized from alcohol, melts at 147-148°C.
The 4-butylaminobenzoic acid β-di-methylaminoethylester monohydrochloride is a colorless crystalline powder, which is easily soluble in water. The solution may be sterilized by boiling without decomposition having to be feared. The base can be precipitated from the aqueous solution of the salt; it is at first in the form of an oil but soon solidifies, forms colorless crystals and melts at 43°C. The picrate melts at 120°C. When treated with oxalic acid, the base forms a neutral oxalate which is easily soluble in water and an acid oxalate which is very difficultly soluble in cold water.
In practice it is usually used as hydrochloride salt.

Therapeutic Function

Local anesthetic

General Description

Tetracaine hydrochloride is a local anesthetic drug and an ester derivative of p-amino benzoic acid. It acts by interfering with the entry of sodium ions into nerve cells and is one of the commonly used topical anesthetics.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

Contact allergens

Amethocaine is a local anesthetic used in dental surgery. It was reported as an agent of contact dermatitis in dentists or dental nurses and in ophthalmologists

Tetracaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Tetracaine hydrochloride Suppliers

Global( 469)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Lvyang Biotechnology Co.,Ltd
15030198922 +86 15030198922
0311-68052281 CHINA 86 58
Jinan Jianfeng Chemical Co., Ltd
0531-88113608 CHINA 200 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897093 CHINA 158 58
0371-55170695 CHINA 26742 58
Hebei Xibaijie Biotechnology Co., Ltd.
0086 15232103582 CHINA 636 58
Xingtai Haoxun Import and Export Trade Co., Ltd.
+8617733977883 WhatsApp:+8617733976525
86-0319-5021664 CHINA 270 58
Hebei Binshare New Material Co. Ltd
+8618633865755 +86-86-18633865755 CHINA 987 58
Wuhan Mulei New Material Technology Co. Ltd
Telegram/wickr: jane8886; China 993 58
Shanxi Lianxu New Material Co., LTD
Whatsapp: +8618903404542 Wickr me: vevian China 528 58
Zhejiang kaitao Import and export Co. LTD CHINA 43 58

Related articles

View Lastest Price from Tetracaine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-18 Tetracaine hydrochloride
US $20.00 / KG 1KG 99% 1000kg/month Shanxi Lianxu New Material Co., LTD
US $150.00 / KG 1KG 99.9% 1000kg/month Shanxi Lianxu New Material Co., LTD
2022-01-18 Tetracaine hydrochloride
US $9.90-9.90 / g/Bag 10g/Bag 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customized packaging 100KG Wuhan Biocar Pharmacy Co., Ltd.

Tetracaine hydrochloride Spectrum

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