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Piroxicam

Used in Particular Diseases
Piroxicam
Piroxicam structure
CAS No.
36322-90-4
Chemical Name:
Piroxicam
Synonyms
Baxo;Erazon;Pirkam;Riacen;Zunden;chf1251;cp16171;Feldene;Geldene;Larapam
CBNumber:
CB1375282
Molecular Formula:
C15H13N3O4S
Formula Weight:
331.35
MOL File:
36322-90-4.mol

Piroxicam Properties

Melting point:
198-200°C
Density 
1.3664 (rough estimate)
refractive index 
1.6320 (estimate)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrous ethanol. It shows polymorphism (5.9).
form 
neat
pka
6.3 (2:1 dioxane-water)
Water Solubility 
Soluble in water, ethanol, chloroform, ethyl acetate.
λmax
358nm(H2O)(lit.)
Merck 
14,7506
InChIKey
QYSPLQLAKJAUJT-UHFFFAOYSA-N
CAS DataBase Reference
36322-90-4(CAS DataBase Reference)
NIST Chemistry Reference
Piroxicam(36322-90-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,F,T
Risk Statements  22-25
Safety Statements  26-36
RIDADR  UN 2811
WGK Germany  3
RTECS  DL0705000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Toxicity LD50 orally in mice: 360 mg/kg (Wiseman)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Piroxicam price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P0847 Piroxicam meets USP testing specifications 36322-90-4 1g $79.3 2018-11-13 Buy
Sigma-Aldrich 1544508 Piroxicam United States Pharmacopeia (USP) Reference Standard 36322-90-4 125mg $348 2018-11-13 Buy
TCI Chemical P1905 Piroxicam >98.0%(HPLC)(T) 36322-90-4 10g $218 2018-11-22 Buy
Alfa Aesar J63239 Piroxicam 36322-90-4 1g $33.4 2018-11-13 Buy
Alfa Aesar J63239 Piroxicam 36322-90-4 5g $127 2018-11-13 Buy

Piroxicam Chemical Properties,Uses,Production

Used in Particular Diseases

Acute Gouty Arthritis:
Dosage and Frequency: 20 mg once daily or 10 mg twice daily

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Non-steroidal anti-inflammatory with long half-life. Cyclooxygenase inhibitor. Clinically useful NSAID

Indications

Piroxicam (Feldene) is indicated for the treatment of rheumatoid arthritis and osteoarthritis. Piroxicam is a nonspecific COX inhibitor that has a much higher affinity for COX-1 than COX-2. This may account for the large proportion (over 30%) of patients receiving long-term therapy who have reported side effects.Adverse GI reactions have been the most frequently reported side effect, but edema, dizziness, headache, rash, and changes in hematological parameters have also occurred in 1 to 6% of patients. Piroxicam can cause serious GI bleeding, ulceration, and perforation, particularly in the elderly, if the recommended dosage is exceeded or if aspirin is being taken concurrently.

Definition

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine.

brand name

Feldene (Pfizer).

General Description

Piroxicam (Feldene) is the most widely used oxicam becauseof its once-daily dosing schedule. It is well absorbedafter oral administration and has a plasma half-life of 50hours, thus requiring a dose of only 20 to 30 mg oncedaily. It undergoes extensive hepatic metabolism, catalyzedby CYP2C9 to give 5-hydroxypiroxicam as its majormetabolite. Several piroxicam prodrugshave been synthesized via derivatization of the enol alcoholgroup (amipiroxicam, droxicam, and pivoxicam) to reducepiroxicam-induced GI irritation.

Biological Activity

Anti-inflammatory; highly selective inhibitor of COX-1 (ratio of IC 50 values for COX-2/COX-1 ~ 600).

Enzyme inhibitor

This long-lasting anti-inflammatory agent (FW = 331.35 g/mol; CAS 36322-90-4), also known as 4-hydroxy-2-methyl-N- (2-pyridyl) -2H-1,2- benzothiazine-3-carboxamide 1,1-dioxide, is a potent inhibitor of prostaglandin production. Target (s) : chloride/ bicarbonate antiports ; collagenase; cyclooxygenase, or prostaglandin-endoperoxide synthase, selective for COX-1; dihydrofolate reductase; elastase, granulocyte; estrone sulfotransferase; leukocyte thioltransferase ; myeloperoxidase; ornithine decarboxylase; oxidative phosphorylation, as an uncoupler; phenol sulfotransferase, or aryl sulfotransferase; phenylpyruvate tautomerase; phosphoribosylamino-imidazolecarboxamide formyltransferase, or AICAR transformylase; and thiopurine S-methyltransferase.

Piroxicam Preparation Products And Raw materials

Raw materials

Preparation Products


Piroxicam Suppliers

Global( 323)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58

View Lastest Price from Piroxicam manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-12 Piroxicam
36322-90-4
US $1.00 / KG 1KG 99% 500kg Hebei Jimi Trading Co., Ltd.
2018-12-17 Piroxicam
36322-90-4
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2019-03-21 Piroxicam ,Riacen,Zunden cas 36322-90-4(whatsapp:+8618830163278)
36322-90-4
US $300.00 / KG 1KG 99.60% 100 Hebei Huanhao Biotechnology Co., Ltd.

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