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Apigenin

Description References
Apigenin
Apigenin structure
CAS No.
520-36-5
Chemical Name:
Apigenin
Synonyms
75580;75590;APIGENIN;Versulin;Apegenin;UCCF 031;apigenol;CHAMOMILE;LY 080400;NSC 83244
CBNumber:
CB1384541
Molecular Formula:
C15H10O5
Formula Weight:
270.24
MOL File:
520-36-5.mol

Apigenin Properties

Melting point:
>300 °C(lit.)
Boiling point:
333.35°C (rough estimate)
Density 
1.2319 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
−20°C
solubility 
DMSO: 27 mg/mL
form 
powder
color 
yellow
Merck 
14,730
BRN 
262620
InChIKey
KZNIFHPLKGYRTM-UHFFFAOYSA-N
CAS DataBase Reference
520-36-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  LK9276000
10
HS Code  29329985
Hazardous Substances Data 520-36-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Apigenin price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 01760595 Apigenin primary pharmaceutical reference standard 520-36-5 10mg $343 2018-11-22 Buy
Sigma-Aldrich 1040683 Apigenin United States Pharmacopeia (USP) Reference Standard 520-36-5 30mg $416 2018-11-13 Buy
TCI Chemical A1514 Apigenin >98.0%(HPLC) 520-36-5 100mg $127 2018-11-22 Buy
Alfa Aesar L15041 4',5,7-Trihydroxyflavone, 97% 520-36-5 25mg $44.5 2018-11-13 Buy
Alfa Aesar L15041 4',5,7-Trihydroxyflavone, 97% 520-36-5 100mg $120 2018-11-13 Buy

Apigenin Chemical Properties,Uses,Production

Description

Apigenin (chemically known as 4′, 5, 7-trihydroxyflavone, with molecular formula C15H10O5) is with molecular weight of 270.24. It is a naturally occurring plant flavone and is abundantly present in common fruits such as grapefruit, plant-derived beverages, and vegetables such as parsley, onions, oranges, tea, chamomile, wheat sprouts and in some seasonings.
Apigenin has gained particular interest in recent years as a beneficial and health promoting agent owing to its low intrinsic toxicity and its striking effects on normal versus cancer cells, compared with other structurally-related flavonoids. It has been increasingly recognized as a cancer and tumor  chemopreventive agent (for breast cancer, cervical cancer, colon cancer, hematologic cancer, lung cancer, ovaria cancer, prostate cancer, skin cancer, thyroid cancer, endometrial cancer, gastric cancer, liver cancer, adrenal cortical cancer, leukemia, and neuroblastoma) owing to its anti-inflammatory, antioxidant and anticancer properties.

References

[1] Sanjeev Shukla, Sanjay Gupta (2010) Apigenin: a promising molecule for cancer prevention, 27, 962-978.
[2] https://en.wikipedia.org/wiki/Apigenin
[3] http://bodynutrition.org/apigenin/

Chemical Properties

Pale Yellow Crystalline Solid

Uses

antispasmodic, antineoplastic, topoisomerase I inhibitor

Uses

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tum or cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.

Uses

Has been used to dye Cr mordanted wool yellow. The color is fast to soap.

General Description

The herb known as chamomile is derived from the plants Matricaria chamomilla (German, Hungarian, or genuine chamomile) and Anthemis nobilis (English, Roman, or common chamomile). Plants from the two genera have similar activities. The medicinal components are obtained from the flowering tops. The flowers are dried and used for chamomile teas and extracts. Chamomile has been used medicinally for at least 2,000 years. The Romans used the herb for its medicinal properties, which they knew were antispasmodic and sedative.
The herb also has a long history in the treatment of digestive and rheumatic disorders. The activity of chamomile is found in a light blue essential oil that composes only 0.5% of the flower. The blue color is caused by chamazulene, 7-ethyl-1,4-dimethylazulene . This compound is actually a byproduct of processing the herb. The major component of the oil is the sesquiterpene (-)-α-bisabolol. Also present are apigenin, angelic acid, tiglic acid, the terpene precursors (farnesol, nerolidol, and germacranolide) coumarin, scopoletin-7-glucoside, umbelliferone, and herniarin. Much of the effect of chamomile is caused by bisabolol . Bisabolol is a highly active anti-inflammatory agent in various rodent inflammation and arthritis tests.

Biological Activity

Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC 50 values are 59.44 and 31.15 μ M at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo .

Anticancer Research

It is a flavone compound found in many fruits and vegetables and abundant in chamomiletea, parsley, celeriac, and celery. It induces apoptosis by targeting leptin/leptin receptor pathway and by targeting caspase-dependent extrinsic pathway aswell as STAT3 signaling pathway in lung adenocarcinoma and BT-474 breast cancercells, respectively (Singh et al. 2016b). It shows antitumor activity against breastcancer MCF-7 cells and colon cancer HCT 116 cells and is a mediator of cancerchemoprevention and an inducer of autophagy. It can be used to treat colon canceras it induces apoptosis in colon cancer cells. It also increase melanogenesis in B16cells by activating the p38 MAPK pathway (Wang et al. 2012).

Purification Methods

Crystallise it from aqueous pyridine or aqueous EtOH. It dyes wool yellow when mixed with Cr ions. [Beilstein 18 H 181, 18 I 396, 18 II 178, 18 III/IV 2682, 18/4 V 574.]

Apigenin Preparation Products And Raw materials

Raw materials

Preparation Products


Apigenin Suppliers

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Hangzhou FandaChem Co.,Ltd.
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View Lastest Price from Apigenin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-15 Apigenin 520-36-5
520-36-5
US $25.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2018-07-26 Apigenin
520-36-5
US $100.00 / KG 25KG 99% 10tons career henan chemical co
2019-04-26 Apigenin
520-36-5
US $100.00 / kg 1kg 99% 500tons/month Hebei Chisure Biotechnology Co., Ltd.

Apigenin Spectrum


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