Mevastatin | 73573-88-3

Mevastatin Properties

Melting point	151-153 °C
alpha	D22 +283° (c = 0.48 in acetone)
Boiling point	555.0±50.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	2-8°C
solubility	DMSO: 20 mg/mL
pka	13.49±0.40(Predicted)
form	powder
color	white
λmax	246nm(MeOH)(lit.)
Merck	14,6164
BRN	1269441
InChIKey	AJLFOPYRIVGYMJ-INTXDZFKSA-N
CAS DataBase Reference	73573-88-3(CAS DataBase Reference)
FDA UNII	1UQM1K0W9X

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Danger
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	22-24/25-45-36/37/39
WGK Germany	3
RTECS	EK7907100
F	1-8-10
HS Code	29322090

Mevastatin price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M2537	Mevastatin ≥95% (HPLC), powder	73573-88-3	5mg	$152	2024-03-01	Buy
Sigma-Aldrich	474700	Mevastatin	73573-88-3	50mg	$159	2024-03-01	Buy
TCI Chemical	M2275	Mevastatin >98.0%(HPLC)	73573-88-3	1g	$248	2024-03-01	Buy
TCI Chemical	M2275	Mevastatin >98.0%(HPLC)	73573-88-3	5g	$621	2024-03-01	Buy
Alfa Aesar	J61357	Mevastatin, 98%	73573-88-3	5mg	$51.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
M2537	5mg	$152	Buy
474700	50mg	$159	Buy
M2275	1g	$248	Buy
M2275	5g	$621	Buy
J61357	5mg	$51.65	Buy

Mevastatin Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

anti-hyperlipoproteinemic, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor

Uses

antihyperlipidemic, HMGCoA reductase inhibitor

Uses

A fungal metabolite which is a potent inhibitor of HMG-CoA reductase.

Uses

Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prtotype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).

Definition

ChEBI: A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group and in which the lactone moiety has been hydrolysed to the corresponding delta-hydroxy-carboxylic acid. A hydroxymethylglutaryl-CoA reductase inhibitor (stati ) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.

General Description

Chemical structure: statin

Biological Activity

Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo . Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27.

Biochem/physiol Actions

Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi. It acts as an antiresorptive?agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras. Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.

storage

Store at RT

Purification Methods

Purify compactin by recrystallisation from aqueous EtOH. UV (EtOH): max 230, 237 and 246nm (log 4.28, 4.30 and 4.11); IR (KBr): 3520, 1750 (lactone CO) and 1710 (CO ester) cm-1. [Clive et al. J Am Chem Soc 110 6914 1988, Review: Rosen & Heathcock Tetrahedron 42 4909 1986, IR, NMR, MS: Brown et al. J Chem Soc Perkin Trans 1 1165 1976.] It is a potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), an enzyme in cholesterol biosynthesis, and lowers cholesterol levels [Brown et al. J Biol Chem 253 1121 1978, Nakamura & Ableles Biochemistry 24 1364 1985, Beilstein 18/3 V 145].

References

[1] endo a. the discovery and development of hmg-coa reductase inhibitors. journal of lipid research, 1992, 33(11): 1569-1582.

Mevastatin Preparation Products And Raw materials

Raw materials

Preparation Products

Mevastatin Suppliers

Global( 341)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Standardpharm Co. Ltd.	58

View Lastest Price from Mevastatin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-01	Mevastatin 73573-88-3	US $0.00-0.00 / g	1g	>=98.5%	500kg	Hangzhou ICH Biofarm Co., Ltd
2023-09-06	Mevastatin 73573-88-3	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2021-08-06	Mevastatin USP/EP/BP 73573-88-3	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

Mevastatin
73573-88-3
US $0.00-0.00 / g
>=98.5%
Hangzhou ICH Biofarm Co., Ltd

Mevastatin
73573-88-3
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Mevastatin USP/EP/BP
73573-88-3
US $1.10 / g
99.9%
Dideu Industries Group Limited

Mevastatin Spectrum

Mevastatin(73573-88-3)¹HNMR

73573-88-3(Mevastatin)Related Search:

METSULFURON METHYL Methyl acrylate Tribenuron methyl Rosuvastatin calcium Methylparaben

Pravastatin Methanol Methyl salicylate Fluvastatin Simvastatin

Atorvastatin Basic Violet 1 Butyric Acid Atorvastatin calcium Kresoxim-methyl

Methyl Lovastatin Pravastatin Lactone

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Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)- ,8-beta(2s*,4s*),8a-beta))- antibioticml236b butanoicacid,2-methyl-,1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hy compactin(penicillium) (S)-2-Methylbutyric acid [(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1-yl] ester 2-Methyl-butanoic acid [1S-[1-α(R*),7-β,8-β(2S*,4S*),8a-β]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester Mevastatin, >=97% (2S)-2-methylbutyric acid [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-keto-tetrahydropyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] ester [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenylbutanoate Mevastatin,Compactin, ML-236B Mevastatin API Lovastatin EP IMpurity A MEVASTATIN(SH) CoMpactin, ML 236B, SIPI 8915 (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-Methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-Methylbutanoate droxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha(r*),7-beta ml236blactone 6-DEMETHYLVEVINOLIN 2-methyl-butanoic acid [1s-[1-alpha(r*),7-beta,8-beta(2s*,4s*),8a-beta]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl ester (2S)-2-METHYL-(1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENYL BUTANOATE MEVASTATIN MEVASTIN CS-500 Merastatin MEVASTATIN 95+% Compactin, 6-Demethylvevinolin, CS-500, ML-236 B MEVASTATIN(RG) COMPACTIN (MEVASTATIN) [(1S,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)- (1S,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthyl (S)-2-methylbutyrate (2S)-2-Methylbutyric acid [(1S)-1,2,3,7,8,8aα-hexahydro-7α-methyl-8α-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1β-yl] ester Compactin, ML-236B Mevastatin (ML236B) Pravastatin Deshydroxy Impurity Mevastatin Solution, 100ppm Mevastatin, 98%, a potent HMG-CoA reductase inhibitor Mevastatin Mevastatin Lovastatin Impurity 1(Lovastatin EP Impurity A) Mevastatin, ≥96%(HPLC) Mevastatin - CAS 73573-88-3 - Calbiochem Lovastatin EP Impurity A (Mevastatin) Mevastatin> sjxqpil80ozl2eonzya8tqee.png Mevastatin USP/EP/BP MEVASTATIN/ COMPACTIN 97% UP Lovastatin EP Impurity A (Pravastatin Deshydroxy Impurity/ Mevastatin/ Compactin) Pravastatin Deshydroxy Impurity (Lovastatin EP Impurity A/ Mevastatin/ Compactin) MevastatinQ: What is Mevastatin Q: What is the CAS Number of Mevastatin Q: What is the storage condition of Mevastatin Q: What are the applications of Mevastatin ML-236B COMPACTIN Lovastatin Impurity A 73573-88-3 BioChemical Antibiotics G-M