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ROKITAMYCIN

ROKITAMYCIN
ROKITAMYCIN structure
CAS No.
74014-51-0
Chemical Name:
ROKITAMYCIN
Synonyms
M-19-Q;TMS 19Q;Rokital;Rikamycin;Ricamycin;ROKITAMYCIN;T'urimyein H4;3''-Propionylleucomycin A5;Leummycin V 4B-bu-tanoate 3 B-propanoate;Leucomycin V, 4B-butanoate 3B-propanoate (9CI)
CBNumber:
CB1388574
Molecular Formula:
C42H69NO15
Formula Weight:
827.99
MOL File:
74014-51-0.mol

ROKITAMYCIN Properties

Melting point:
116°
alpha 
D20 -71° (c = 1.0 in chloroform)

SAFETY

ROKITAMYCIN price

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ROKITAMYCIN Chemical Properties,Uses,Production

Description

Rokitamycin is a semisynthetic macrolide antibiotic, closely related to miokamycin(2) both in structure and antimicrobial spectrum.

Originator

Toyo Jozo (Japan)

brand name

RICAMYCIN

Pharmaceutical Applications

3″-Propionyl leucomycin A5. A semisynthetic macrolide. Unstable in acid media.
The antibacterial spectrum is identical to that of erythromycin, but it is less active against Gram-positive cocci. It is poorly active against H. influenzae (MIC50 8 mg/L) and Mor. catarrhalis (MIC50 4 mg/L). It displays good activity against Campylobacter spp. (MIC50 0.1 mg/L), L. pneumophila (MIC50 0.1 mg/L) and M. pneumoniae (MIC50 0.003 mg/L). It is active against anaerobes, including some Bacteroides spp. (MIC50 <0.05 mg/L).
After a single oral dose of 600 mg, the peak plasma concentration was 1.9 mg/L after 0.6 h. Oral doses of 5, 10 and 15 mg/kg of a syrup formulation given to children achieved plasma concentrations of 0.26, 0.55 and 0.79 mg/L, respectively, after about 40 min. The half-life is around 2 h.
It is mainly eliminated in the bile; only about 2% appears in the urine. Its major metabolites are leucomycin A7, 10″-OH-rokitamycin (which show some antibacterial activity) and leucomycin V. In healthy adult volunteers, the proportions of rokitamycin and its metabolites in serum 30 min after a single oral dose of 1200 mg were 18% (leucomycin A7), 33% (10″-OH-rokitamycin) and 9% (leucomycin V). The pharmacokinetic behavior is not altered in patients with liver cirrhosis. It is available in Italy and Japan.

ROKITAMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products


ROKITAMYCIN Suppliers

Global( 15)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58

74014-51-0(ROKITAMYCIN)Related Search:


  • ROKITAMYCIN
  • 3''-Propionylleucomycin A5
  • Leucomycin V, 4B-butanoate 3B-propanoate (9CI)
  • Ricamycin
  • TMS 19Q
  • Leummycin V 4B-bu-tanoate 3 B-propanoate
  • M-19-Q
  • Rikamycin
  • Rokital
  • T'urimyein H4
  • 74014-51-0
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