(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL
- CAS No.
- 1430202-70-2
- Chemical Name:
- (2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL
- Synonyms
- (2S,6S)-Hydroxynorketamine;2S,6S-Hydroxynorketamine hydrochloride;(2S,6S)-Hydroxynorketamine hydrochloride >=98% (HPLC);(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL;(2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride;(2S,6S)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochloride;(2S,6(2S,6S)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochlorideS)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochloride
- CBNumber:
- CB13941800
- Molecular Formula:
- C12H15Cl2NO2
- Molecular Weight:
- 276.159
- MDL Number:
- MFCD30720898
- MOL File:
- 1430202-70-2.mol
- MSDS File:
- SDS
(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1875 | (2S,6S)-Hydroxynorketamine hydrochloride ≥98% (HPLC) | 1430202-70-2 | 5mg | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1875 | (2S,6S)-Hydroxynorketamine hydrochloride ≥98% (HPLC) | 1430202-70-2 | 25mg | $212 | 2024-03-01 | Buy |
| Tocris | 6095 | (2S,6S)-Hydroxynorketamine hydrochloride ≥98%(HPLC) | 1430202-70-2 | 10 | $303 | 2021-12-16 | Buy |
(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL Chemical Properties,Uses,Production
Uses
2S,6S-Hydroxynorketamine Hydrochloride is a compound used in the treatment of neurological disorders such as depression, anxiety and various phobias involving social interaction. N-methyl-D-apartate receptor antagonist. Antidepressant.
Biochem/physiol Actions
(2S,6S)-Hydroxynorketamine hydrochlorideKetamine is a metabolite associated with increased locomotor activity and motor incoordination.It has been found that the NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects, while (2S,6S)-hydroxynorketamine was associated with increased locomotor activity and motor incoordination. (2S,6S)-HNK, was also found to increase the function of the mammalian target of rapamycin (mTOR) 2-fold at 0.05 nM. (2S,6S)-HNK and (2R,6R)-HNK both inhibited intracellular concentrations of D-serine, an endogenous NMDA receptor co-agonist, with IC50 values of 0.18 nM and 0.68 nM, respectively. Neither bind with high affinity to NMDA receptors, with Ki values of 21.19 μM and > 100 μM for (2S,6S)-HNK and (2R,6R)-HNK, respectively.
storage
Store at RT
(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9574 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 13417589054 | trendseenbio@gmail.com | China | 8941 | 58 |
| Shureli Biopharma Co.,Ltd | 0871-68355600 18787766125 | 756338076@qq.com | China | 536 | 58 |