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Cinchocaine

CAS No.
85-79-0
Chemical Name:
Cinchocaine
Synonyms
Dibucain;percamine;DIBUCAINE;INN / BAN;Dermacaine;Nupercaine;Nupercainal;CINCHOCAINE;Zinn cocaine;DIBUCAINE BASE
CBNumber:
CB1396856
Molecular Formula:
C20H29N3O2
Molecular Weight:
343.46
MDL Number:
MFCD00047595
MOL File:
85-79-0.mol
Last updated:2024-03-20 19:26:33

Cinchocaine Properties

Melting point 64°
Boiling point 478.73°C (rough estimate)
Density 1.1145 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. Store at -20°C
solubility DMSO:45.0(Max Conc. mg/mL);131.02(Max Conc. mM)
pka pKa -5.3(aq. H2SO4) (Uncertain)
form Solid:particulate/powder
Water Solubility 68.01mg/L(temperature not stated)
InChI InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
InChIKey PUFQVTATUTYEAL-UHFFFAOYSA-N
SMILES N1C2C(=CC=CC=2)C(C(NCCN(CC)CC)=O)=CC=1OCCCC
LogP 4.4 at 25℃ and pH7
CAS DataBase Reference 85-79-0(CAS DataBase Reference)
FDA 21 CFR 310.545
FDA UNII L6JW2TJG99
ATC code C05AD04,D04AB02,N01BB06,S01HA06,S02DA04
NIST Chemistry Reference Dibucaine(85-79-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS05
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
RTECS  GD3150000
NFPA 704
0
3 0

Cinchocaine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22237 Dibucaine ≥98% 85-79-0 1mg $44 2024-03-01 Buy
Cayman Chemical 22237 Dibucaine ≥98% 85-79-0 5mg $109 2024-03-01 Buy
Biosynth Carbosynth FC33247 Cinchocaine - USP 85-79-0 50g $140 2021-12-16 Buy
ChemScene CS-2656 Dibucaine 99.83% 85-79-0 10g $173 2021-12-16 Buy
Biosynth Carbosynth FC33247 Cinchocaine - USP 85-79-0 100g $200 2021-12-16 Buy
Product number Packaging Price Buy
22237 1mg $44 Buy
22237 5mg $109 Buy
FC33247 50g $140 Buy
CS-2656 10g $173 Buy
FC33247 100g $200 Buy

Cinchocaine Chemical Properties,Uses,Production

Originator

Cincain,Ophtha

Uses

Cinchocaine is a local anesthesic,used for Na+ channel blocker.

Definition

ChEBI: A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally o ly used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.

Manufacturing Process

A benzene solution of 2.2 parts of α-chloro-γ-quinoline-carboxylic acid chloride is gradually mixed, while cooling, with 2.3 parts of unsymmetrical diethylethylenediamine. When the reaction is at an end the solution is washed with water and the new base extracted by means of hydrochloric acid. The base is precipitated by means of sodium carbonate and extracted with benzene. The solvent is distilled and the base recrystallized from petroleum ether. The α-chloro-γ-quinoline-carboxylic acid diethyl-amino-ethylene amide forms colorless lamina crystals of melting point 74°C. With acids the base forms neutral salts soluble in water.
A solution of 2.5 parts of sodium in n-butylalcohol is boiled with 30 parts of α- chloro-γ-quinoline-carboxylic acid diethyl-amino-ethylene-amide in a reflux apparatus, and when the reaction is over the excess of butylalcohol is distilled. The remaining base is taken up with ether; the solution is washed with water and dried. The solvent is then distilled. The α-n-butoxy-γ-quinolinecarboxylic acid diethyl-amino-ethylene-amide forms as colorless crystals, after recrystallization from petroleum ether melting point of it 64°C.
In practice it is usually used as hydrochloride.

brand name

Nupercaine (Novartis).

Therapeutic Function

Local anesthetic

General Description

Articaine has a secondary nitrogen with a pKa of 7.8. It containsan aromatic thiophene ring bioisostere of the phenylring found in most other amide anesthetics. The log P of abenzene ring is 2.13 and the thiophene ring log P is 1.81,thus the thiophene ring is more hydrophilic than a phenylring. Although the thiophene ring has less lipid solubilitythan a phenyl ring, articaine is a lipid-soluble compound dueto the propylamine, the branched methyl and the substitutionson the thiophene ring. The onset of action of articaineis similar to lidocaine’s onset of action.

Contact allergens

Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.

Clinical Use

Articaine is availablein a 4% solution with epinephrine for use in infiltrationand nerve block anesthesia.Articaine is metabolized rapidly via plasma and tissuecarboxyesterase to its primary metabolite, the inactive,water-soluble carboxylic acid. Approximately 40% to 70%of articaine administered epidurally is metabolized to thecarboxylic acid, articainic acid. Approximately 4% to 15%of the articainic acid undergoes glucuronide conjugationand only 3% of the dose is recovered unchanged in theurine. The rapid plasma metabolism and reported inactivityof the carboxylic acid metabolite make articaine a potentiallysafer anesthetic agent when multiple or large dosesare necessary.

87864-14-0
71-36-3
85-79-0
Synthesis of Cinchocaine from 2-Chloro-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide and 1-Butanol

Cinchocaine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 181)Suppliers
Supplier Tel Email Country ProdList Advantage
Xiamen Wonderful Bio Technology Co., Ltd.
+8613043004613 Sara@xmwonderfulbio.com China 305 58
Sigma Audley
+86-18336680971 +86-18126314766 nova@sh-teruiop.com China 524 58
Shanghai Aosiris new Material Technology Co., LTD
+8617513190836 wrjmoon2000@163.com China 231 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Shanghai Bojing Chemical Co.,Ltd.
+86-86-02137122233 +8613795318958 bj1@bj-chem.com China 297 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 7836 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58

View Lastest Price from Cinchocaine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cinchocaine pictures 2024-03-28 Cinchocaine
85-79-0
US $45.00-21.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD
Cinchocaine pictures 2024-03-20 Cinchocaine
85-79-0
US $3.00-1.00 / kg 1kg 99.9% 10 tons Shanghai Aosiris new Material Technology Co., LTD
Cinchocaine pictures 2024-02-21 Cinchocaine
85-79-0
US $25.00-10.00 / kg 1kg 99.8% 200tons/year Sigma Audley
  • Cinchocaine pictures
  • Cinchocaine
    85-79-0
  • US $45.00-21.00 / kg
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • Cinchocaine pictures
  • Cinchocaine
    85-79-0
  • US $3.00-1.00 / kg
  • 99.9%
  • Shanghai Aosiris new Material Technology Co., LTD
  • Cinchocaine pictures
  • Cinchocaine
    85-79-0
  • US $25.00-10.00 / kg
  • 99.8%
  • Sigma Audley

Cinchocaine Spectrum

2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamid 2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamid 2-butoxy-n-(2-(diethylamino)ethyl)cinchoninamide 2-butoxy-n-(2-(diethylamino)ethyl-4-quinolinecarboxamid 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide 2-Butoxy-N-[2-(diethylamino)ethyl]cinchoninamide 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide 2-butoxyquinoline-4-carboxylicaciddiethylaminoethylamide 2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamide 4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]- alpha-butyloxycinchonicacid-gamma-diethylethylenediamine alpha-Butyloxycinchoninic acid diethylethylenediamide alpha-butyloxycinchoninicaciddiethylethylenediamide Cinchoninamide, 2-butoxy-N-[2-(diethylamino)ethyl]- Dermacaine Dibucain dibucainesolution n-(2-(diethylamino)ethyl)-2-butoxycinchoninamide N-[2-(Diethylamino)ethyl]-2-butoxycinchoninamide Nupercainal Nupercaine percamine dibucaine free base crystalline Cinchocaine (Dibucaine) Dibucaine(baseand/orunspecifiedsalts) Cinchocainebase Cinchocaine HCl (base) 2-BUTOXY-N-[2-(DIETHYLAMINO)-ETHYL]-4-QUINOLINE CARBOXAMIDE 2-BUTOXY-N-[2-(DIETHYLAMINO)ETHYL]CINCHONAMIDE 2-butoxy-n-(2-diethylaminoethyl)quinoline-4-carboxamide A-BUTOXYCINCHONINIC ACID DIETHYLETHYLENEDIAMIDE CINCHOCAINE DIBUCAINE DIBUCAINE BASE Dibucaine(Cinchocaine Dibucaine,Sovcaine,Percaine) Cinchocaine - USP Chloroprocaine hydrochloride Solution, 100ppm 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide hydrochloride, calculated with reference to the dried substance. Zinn cocaine Cinchocaine USP/EP/BP Dibucaine/ocaine Nepocaine Dibucaine (Cinchocaine) CinchocaineQ: What is Cinchocaine Q: What is the CAS Number of Cinchocaine Q: What is the storage condition of Cinchocaine INN / BAN 85-79-0 61-21-1 C20H29N3O2 research chemical DIA - DICDrugs of Abuse Alphabetic Chemical Structure D Others 85-79-0