Orphenadrine
- CAS No.
- 83-98-7
- Chemical Name:
- Orphenadrine
- Synonyms
- C07935;Disipal;WS 2434;Biorphen;Orphenadine;Orphenadrin;Orphenedrine;orphenadrine;AURORA KA-7797;Ophenadrinecitrate
- CBNumber:
- CB1397020
- Molecular Formula:
- C18H23NO
- Molecular Weight:
- 269.38
- MDL Number:
- MFCD00053670
- MOL File:
- 83-98-7.mol
| Melting point | 25°C |
|---|---|
| Boiling point | bp12 195° |
| Density | 1.0278 (rough estimate) |
| refractive index | 1.5740 (estimate) |
| pka | pKa 8.4 (Uncertain) |
| Water Solubility | 1.801mg/L(22.5 ºC) |
| CAS DataBase Reference | 83-98-7 |
| EWG's Food Scores | 1 |
| FDA UNII | AL805O9OG9 |
| ATC code | M03BC51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | 1851 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in mouse: 125mg/kg |
Orphenadrine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0000039 | ORPHENADRINE RELATED COMPOUND C 95.00% | 83-98-7 | 1G | $525 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0000039 | ORPHENADRINE RELATED COMPOUND C 95.00% | 83-98-7 | 5G | $1370.41 | 2021-12-16 | Buy |
Orphenadrine Chemical Properties,Uses,Production
Originator
Norflex,Riker,US,1959
Uses
Relaxant (skeletal muscle); antihistaminic.
Definition
ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Manufacturing Process
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.
brand name
Norflex (3M Pharmaceuticals).
Therapeutic Function
Muscle relaxant
Enzyme inhibitor
This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol; CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist that also inhibits some cytochrome P450 systems. Classified as an anticholinergic drug (with 58% as potent as atropine) and an ethanolamineclass antihistamine, it also inhibits the noradrenergic transporter and NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either the hydrochloride or citrate salt, orphenadrines used to relieve pain of muscle injuries, such as strains and sprains. Target(s): aldehyde oxidase; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor; noradrenaline reuptake.
Orphenadrine Preparation Products And Raw materials
Orphenadrine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9165 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
View Lastest Price from Orphenadrine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-28 | Orphenadrine USP/EP/BP
83-98-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Orphenadrine USP/EP/BP
83-98-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited