PAI-1
- CAS No.
- Chemical Name:
- PAI-1
- Synonyms
- PAI-1;ARMAPE;PAI-1, RAT;MOUSE PAI-1;PAI-1, MOUSE;PAI-1, HUMAN;PAI-1, MUTANT, MOUSE;PLASMINOGEN ACTIVATOR INHIBITOR 1;PLASMINOGEN ACTIVATOR INHIBITOR-1, RAT;MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1
- CBNumber:
- CB1438644
- Molecular Formula:
- C27H47N9O9S
- Molecular Weight:
- 673.78
- MDL Number:
- MFCD00080197
- MOL File:
- Mol file
PAI-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 528205 | Plasminogen Activator Inhibitor-1, Human, Recombinant The Plasminogen Activator Inhibitor-1, Human, Recombinant controls the biological activity of Plasminogen Activator. This small molecule/inhibitor is primarily used for Protease Inhibitors applicatio | 50μg | $390 | 2024-03-01 | Buy | |
| Usbiological | 027470 | Plasminogen Activator Inhibitor 1 | 96Tests | $706 | 2021-12-16 | Buy | |
| Usbiological | 156349 | Plasminogen Activator Inhibitor 1 | 10ug | $333 | 2021-12-16 | Buy | |
| Usbiological | 027469 | Plasminogen Activator Inhibitor 1 | 96Tests | $851 | 2021-12-16 | Buy | |
| Usbiological | P4256-39 | Plasminogen Activator Inhibitor Type 1, active, Rabbit Assay Kit, BioAssay™ | 1Kit | $1042 | 2021-12-16 | Buy |
PAI-1 Chemical Properties,Uses,Production
Enzyme inhibitor
This 402-residue serine protease inhibitor, or serpin (MW = 45074 g/mol; Abbreviation: PAI-1) binds to and inhibits plasminogen activators-tissuetype plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). This inhibition reduces plasmin production and suppresses dissolution of fibrin clots. Elevated PAI-1 levels correlate with an increased cardiovascular disease risk, a behavior that has also been linked to obesity and metabolic syndrome. Pharmacological suppression of PAI-1 is a likely way to prevent or treat vascular disease. Reduced PAI-1 levels may result in increased fibrinolysis and an associated bleeding diathesis. PAI-1 was initially identified in the 1980s, and the first reported case of PAI-1 deficiency appeared in 1989. Unambiguous proof that PAI-1 deficiency as a cause of a bleeding disorder has been rare, but use of selective PAI inhibitors (See PAI-749) may clarify this point. Because of lack of standardized commercially available PAI-1 activity assay sensitive in the lowest range, the true prevalence of this rare condition has yet to be established.
PAI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
PAI-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 6633 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yaji Biological Technology Co., Ltd. | 58 |
| Shanghai Huzhen Industrial Co., LTD | 58 |
| United States Biological | 58 |