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ALPHA-MSH

CAS No.
581-05-5
Chemical Name:
ALPHA-MSH
Synonyms
a-MSH;C02758;ALFA-MSH;ALPHA-MSH;-MSH;α-MSH, amide;α-Melanotropin;alpha-Intermedin;ALPHA-MSH, AMIDE;ALPHA-MSN, HUMAN
CBNumber:
CB1440232
Molecular Formula:
C77H109N21O19S
Molecular Weight:
1664.88
MDL Number:
MFCD00133062
MOL File:
581-05-5.mol
Last updated:2023-06-30 15:45:59

ALPHA-MSH Properties

Density 1.48±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility insoluble in EtOH; ≥10.44 mg/mL in H2O with ultrasonic; ≥166.5 mg/mL in DMSO with gentle warming
pka 4.43±0.10(Predicted)
form Lyophilized
Water Solubility Soluble in water (~1 mg/ml).
BRN 741840
FDA UNII OVF025LA77

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

ALPHA-MSH price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M4135 α-Melanocyte stimulating hormone ≥97% (HPLC) 581-05-5 1mg $131 2024-03-01 Buy
Sigma-Aldrich 05-23-0751 α-Melanocyte-Stimulating Hormone Synthetic α-melanocyte-stimulating hormone. 581-05-5 1mg $105 2024-03-01 Buy
Alfa Aesar J64310 alpha-Melanocyte Stimulating Hormone amide 581-05-5 1mg $61.5 2023-06-20 Buy
Alfa Aesar J64310 alpha-Melanocyte Stimulating Hormone amide 581-05-5 5mg $157 2023-06-20 Buy
Sigma-Aldrich M4135 α-Melanocyte stimulating hormone ≥97% (HPLC) 581-05-5 5mg $445 2024-03-01 Buy
Product number Packaging Price Buy
M4135 1mg $131 Buy
05-23-0751 1mg $105 Buy
J64310 1mg $61.5 Buy
J64310 5mg $157 Buy
M4135 5mg $445 Buy

ALPHA-MSH Chemical Properties,Uses,Production

Synthesis and release

In rodents, α-MSH release is under strong inhibitory control by direct innervation from hypothalamic neurons. Dopamine plays a role as a physiological melanotropin release-inhibiting hormone (MRIH). In contrast to ACTH release from corticotropes in the pars distalis of the pituitary, there is no apparent negative feedback control on α-MSH release from melanotropes. Similar mechanisms of regulation have also been demonstrated in amphibians. In humans, the pars intermedia is functional in the fetus and neonate, whereas adults lack the pars intermedia.

Receptors

α-MSH and other MSH peptides interact with four of the five subtypes of melanocortin receptors (MC1R, MC3R, MC4R, and MC5R, excluding the ACTH-specific receptor MC2R), which are members of the GPCR family. Among them, MC1R is a classical α-MSH receptor. ACTH interacts with all five MC receptors. α-MSH activates the AC/PKA pathway via G proteins. 

Agonists and Antagonists

NDP-MSH and MT-II are agonists for human MC1R, MC3R, MC4R, and MC5R. Kd for [125I]NDP-MSH: 0.33 nM (MC1R), 0.2 nM (MC3R), 4–1.2 nM (MC4R), 2.8 nM (MC5R). HS024 is an antagonist for human MC1R, MC3R, MC4R, and MC5R.

Clinical implications

The antiinflammatory activity of α-MSH includes immunomodulatory effects on several resident skin cells and antifibrogenic effects mediated via MC1R that are expressed by dermal fibroblasts. In human mast cells, α-MSH appears to be proinflammatory due to histamine release. α-MSH exhibits cytoprotective activity against ultraviolet B-induced apoptosis and DNA damage, which is associated with the increased risk of cutaneous melanoma in individuals with the loss of function MC1R mutation. The congenital deficiency of POMC results in a syndrome of hypoadrenalism, severe obesity, and altered skin and hair pigmentation. In one case from a Turkish family, a child who was homozygous for a frameshift mutation in the N-terminal region of POMC, and was thus predicted to have a loss of all POMC-derived peptides, showed typical symptoms of POMC deficiency. However, this child did not have red hair, unlike cases of Northern European origin.

Biological functions

α-MSH and other MSH peptides are associated with a wide spectrum of biological functions through MC receptors that distribute in many tissues. MC1R is expressed in melanocytes, keratinocytes, macrophages, leukocytes, and adipose tissue; MC3R is expressed in the central nervous system (CNS), kidney, testis, ovary, skeletal muscle, placenta, and mammary gland; MC4R is expressed in the CNS and associated with food intake; and MC5R is expressed in exocrine glands, muscle, and the CNS. The representative physiological functions of MSH peptides mediated by MC receptors are stimulation of melanocytes in the skin to synthesize melanin, including regulation of the eumelaninpheomelanin switch via MC1R; energy homeostasis and natriuresis via MC3R; energy homeostasis and erectile function via MC4R; and synthesis and secretion of exocrine gland products via MC5R.

Description

A pituitary hormone secreted from the pars intermedia, MSH was one of the first adenohypophysial hormones demonstrated to be present in vertebrates, from jawless fish to mammals, together with adrenocorticotropic hormone (ACTH). The fact that MSH is derived from a precursor protein called proopiomelanocortin (POMC) was demonstrated in 1979, using the pars intermedia from the bovine pituitary.

Uses

alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

General Description

α-Melanocyte-stimulating hormone (α-MSH) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. Pro-inflammatory cytokines or UV light induced epidermal cells such as keratinocytes and melanocytes synthesize and discharge α–MSH. Poopiomelanocortin (POMC) acts as a precursor for α-Melanocyte-stimulating hormone (α-MSH) production.

Biochem/physiol Actions

α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α?MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock. α-MSH has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Clinical Use

The measurement of the blood concentration of MSH has not been validated for routine clinical use. MSH analogs have recently been developed for antiobesity medication, treatment of skin diseases, and prevention of actinic keratoses in organ transplant recipients. The potential use of radiolabeled α-MSH peptides in melanoma imaging and the treatment of disseminated disease has also been reported.

storage

Store at -20°C

Purification Methods

Its solubility in H2O is 1mg/mL. It is separated from the extract by ion-exchange on carboxymethyl cellulose, desalted, evaporated and lyophilised, then chromatographed on Sephadex G-25. [Lande et al. Biochemical Preparations 13 45 1971.]

Structure and conformation

Three types of MSH molecules, with different amino acid sequences, are contained in the common precursor POMC in mammals. α-Melanocyte-stimulating hormone (α-MSH) is composed of 13 aa residues. This peptide is generated from the N-terminal region of the adrenocorticotropic hormone (ACTH), and corresponds to acetylACTH(1–13)-amide. In MSH, the N-terminal Ser residue is free, monoacetylated at the N position, or diacetylated at the N and O positions, whereas the carboxyl terminal is consistently in the amide form. These variations of MSH are called desacetyl-α-MSH, α-MSH, and diacetyl-α-MSH, respectively. Of these peptides, α-MSH is a classical α-MSH. β-MSH, which is generated from POMC via β-lipotropin (β-LPH), is composed of 18 aa residues. Unlike α-MSH, in β-MSH both termini are free. γ-MSH is produced from POMC via pro-γ-MSH or N-POMC, which consists of γ-MSH together with a joining peptide. γ-MSH (also known as γ1-MSH) is composed of 12 aa residues in which the N-terminus and the C-terminus are free and amide, respectively. γ3-MSH is composed of 25 aa residues in which the N-terminal region corresponds to γ1-MSH. Each MSH segment is flanked by basic amino acid residues. Cartilaginous fish such as sharks, rays, and ratfish possess δ-MSH in addition to the three other MSH peptides. Comparison with the amino acid sequence and topology of POMC suggests that δ-MSH might have evolved from β-MSH. Accordingly, α-MSH and γ-MSH are suggested to share an antecedent. Teleost POMC lacks γ-MSH.
	ALPHA-MSH

ALPHA-MSH Preparation Products And Raw materials

Raw materials

Preparation Products

ALPHA-MSH Suppliers

Global( 154)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
Wuhan Boyuan Import & Export Co., LTD
+86-15175982296 15175982296; Mike@whby-chem.com China 981 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213 info@longyupharma.com China 2530 58
Cellmano Biotech Limited
0551-65326643 18156095617 info@cellmano.com China 999 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58

View Lastest Price from ALPHA-MSH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
a-Melanotropin pictures 2024-01-08 a-Melanotropin
581-05-5
US $25.00 / kg 1kg 99.96% 500ton Wuhan Boyuan Import & Export Co., LTD
ALPHA-MSH pictures 2023-11-27 ALPHA-MSH
581-05-5
US $0.00 / MG 10MG 99% 20 TONS Wuhan Senwayer Century Chemical Co.,Ltd
ALPHA-MSH pictures 2023-11-01 ALPHA-MSH
581-05-5
US $0.00-0.00 / g 1g 98% HPLC 100kg Hangzhou ICH Biofarm Co., Ltd
  • a-Melanotropin pictures
  • a-Melanotropin
    581-05-5
  • US $25.00 / kg
  • 99.96%
  • Wuhan Boyuan Import & Export Co., LTD
  • ALPHA-MSH pictures
  • ALPHA-MSH
    581-05-5
  • US $0.00 / MG
  • 99%
  • Wuhan Senwayer Century Chemical Co.,Ltd
  • ALPHA-MSH pictures
  • ALPHA-MSH
    581-05-5
  • US $0.00-0.00 / g
  • 98% HPLC
  • Hangzhou ICH Biofarm Co., Ltd

ALPHA-MSH Spectrum

N-Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 α-Melanotropin【pig】 -Melanocyte-stimulating hormone -Melanotropin, &alpha -MSH α-MSH Acetyl-ACTH (1-13) aMide, α-Melanotropin (huMan) Acetyl-ACTH (1-13) aMide, a-Melanotropin (huMan) Α-MELANOCYTE STIMULATING HORMONE ≥97% Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt alpha-Melanotropin (human) Acetate ALFA-MSH alpha-Intermedin C02758 Α-MELANOCYTE STIMULATING HORMONE N-ACETYL-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 MELANOCYTE STIMULATING HORMONE MELANOCYTE STIMULATING HORMONE, ALPHA-HUMAN ALPHA-MELANOTROPIN ALPHA-MELANOCYTE STIMULATING HORMONE ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE ALPHA-MELANOCYTE STIMULATING HORMONE (HUMAN, PORCINE, BOVINE, RAT, MOUSE) ALPHA-MSH ALPHA-MSH, AMIDE ALPHA-MSH (HUMAN, PORCINE, BOVINE, RAT, MOUSE) ALPHA-MSH STIM HORMONE ALPHA-MSN, HUMAN AC-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 AC-SYSMEHFRWGKPV-NH2 ACETYL ADRENOCORTICOTROPIC HORMONE (1-13) AMIDE ACETYL-ACTH (1-13) AMIDE ACETYL-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL NH2 ALPHA-MELANOCYTEN-STIMULIERENDES HORMON* a-MSH AC-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH α-Melanotropin, α-MSH alpha-Melanocyte Stimulating Hormone (human) Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 α-Melanotropin (human) Acetate, α-MSH α-Melanocyte stimulating hormone, ≥97% (HPLC) α-Melanotropin (swine) α-MSH, amide Mouse melanocyte stimulating hormone elisa kit ALPHA-MSH USP/EP/BP α-Melanotropin (human) α-MSH trifluoroacetate salt α-Melanotropin(swine) α-Melanotropin (human) Acetate amide Acetate(581-05-5 free base) a-MSH, amide Acetate(581-05-5 free base) Melanocortin Receptor,hormone,αMSH,inhibit,Inhibitor,α MSH,neuroimmunomodulatory,inflammation,endogenous,MC Receptor,peptide,anti-inflammatory,α-MSH a MSH, amide Acetate(581 05 5 free base),aMSH, amide Acetate(581055 free base) α-Melanotropin Ac-ACTH (1-13) amide alpha-MSH, amide|alpha-Melanocyte Stimulating Hormone α-MSH (CZEN-002) 581-05-5 C77H109N21O19S Cell Biology