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4-Nitro-o-phenylenediamine

4-Nitro-o-phenylenediamine structure

CAS No.: 99-56-9

Chemical Name:: 4-Nitro-o-phenylenediamine

Synonyms: 4-nitrobenzene-1,2-diamine;4-NITRO-1,2-PHENYLENEDIAMINE;4-n-o-pda;p-nitro-o-phenylenediamine;4ndb;4-no;4-nop;4-nopd;4NOPPDA;202-766-3

CBNumber:: CB1453625

Molecular Formula:: C6H7N3O2

Molecular Weight:: 153.14

MDL Number:: MFCD00007724

MOL File:: 99-56-9.mol

MSDS File:: SDS

Last updated:2023-12-28 17:10:49

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4-Nitro-o-phenylenediamine Properties

Melting point	199-201 °C (lit.)
Boiling point	276.04°C (rough estimate)
Density	1.3682 (rough estimate)
refractive index	1.6910 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	1 N HCl: ethanol, 1:1: soluble50mg/mL
form	Powder
pka	2.06±0.10(Predicted)
color	Brown-red
Water Solubility	1.2 g/L (20 ºC)
Merck	14,6622
BRN	608106
Stability	Stable. Incompatible with strong acids, strong reducing agents, strong oxidizing agents, acid chlorides, acid anhydrides.
InChIKey	RAUWPNXIALNKQM-UHFFFAOYSA-N
CAS DataBase Reference	99-56-9(CAS DataBase Reference)
EWG's Food Scores	3-5
FDA UNII	5A9AX7Y0TT
IARC	3 (Vol. 16, Sup 7) 1987
EPA Substance Registry System	Nitro-o-phenylenediamine (99-56-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317

Precautionary statements

P280-P301+P312+P330-P302+P352

Hazard Codes

Risk Statements

22-43-68-40-36/37/38-20/21/22

Safety Statements

36/37-45-36-26-22

RIDADR

2811

WGK Germany

RTECS

ST2975000

TSCA

Yes

HazardClass

6.1

PackingGroup

HS Code

29215119

Toxicity

LD50 oral in rat: 681mg/kg

NFPA 704

	1
2		0

4-Nitro-o-phenylenediamine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	108898	4-Nitro-o-phenylenediamine 98%	99-56-9	5g	$36.4	2024-03-01	Buy
Sigma-Aldrich	108898	4-Nitro-o-phenylenediamine 98%	99-56-9	100g	$101	2024-03-01	Buy
TCI Chemical	D0103	4-Nitro-1,2-phenylenediamine >97.0%(GC)(T)	99-56-9	25g	$25	2024-03-01	Buy
TCI Chemical	D0103	4-Nitro-1,2-phenylenediamine >97.0%(GC)(T)	99-56-9	100g	$58	2024-03-01	Buy
Alfa Aesar	L04693	4-Nitro-o-phenylenediamine, 97%	99-56-9	100g	$63.9	2024-03-01	Buy

Product number	Packaging	Price	Buy
108898	5g	$36.4	Buy
108898	100g	$101	Buy
D0103	25g	$25	Buy
D0103	100g	$58	Buy
L04693	100g	$63.9	Buy

4-Nitro-o-phenylenediamine Chemical Properties,Uses,Production

Chemical Properties

This substance is an orange-red powder that can be dissolved in ethanol, acetone, and hydrochloric acid solution, but is not soluble in water.

Uses

4-Nitro-o-phenylenediamine was used to study the in vitro activation of 4-nitro-o-phenylenediamine into a potent mutagen in Salmonella typhimurium strain TA98 .

Production Methods

Commercial production of 4-nitro-o-PDA was first reported in the United States in 1946. Two U.S. companies were reported to produce undisclosed amounts of the chemical in 1975. U.S. imports of 4-nitro-o-PDA were reported to be about 1900 kg in 1973 and 1100 kg in 1975. 4-Nitro-o-PDAis used in fur dyes, inks, and semipermanent yellow hair coloring formulations requiring a yellow color component that does not involve the use of hydrogen peroxide in the color development.
Occupational exposure to 4-nitro-o-PDA may occur through inhalation and dermal contact with this compound at workplaces where p-PDA is produced or used. The general population may be exposed to the compound via dermal contact, primarily through the use of hair dyes containing this compound.

Definition

ChEBI: 4-nitro-1,2-phenylenediamine is the primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group. It is a primary amino compound and a C-nitro compound. It is functionally related to a 1,2-phenylenediamine.

Application

4-Nitro-1,2-phenylenediamine is a hair dye constituent with potential mutagenic activity. It is used in oxidation hair dye formulations at a maximum concentration of 1.0 %, which after mixing typically in a 1:1 ratio with hydrogen peroxide just prior to use, corresponds to a concentration of 0.5% upon application.

Preparation

Prepared by reduction of 2,4-dinitroaniline using H2S in ammonia water.

General Description

4-nitro-o-phenylenediamine appears as dark red needles or red solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Nitro-o-phenylenediamine is incompatible with strong oxidizing agents, strong acids, strong reducing agents, acid chlorides and acid anhydrides.

Fire Hazard

Flash point data for 4-Nitro-o-phenylenediamine are not available; however, 4-Nitro-o-phenylenediamine is probably combustible.

Biochem/physiol Actions

4-Nitro-o-phenylenediamine is a direct-acting mutagen.

Safety Profile

Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx,.

Purification Methods

Crystallise the diamine from water. [Beilstein 13 IV 75.]

4-Nitro-o-phenylenediamine synthesis

Synthesis of 4-Nitro-o-phenylenediamine from 2,4-Dinitroaniline

4-Nitro-o-phenylenediamine Preparation Products And Raw materials

Raw materials

2,4-Dinitroaniline Activated carbon,decolor Benzenamine, N-hydroxy-2,4-dinitro- benzene-1,2,4-triyltriamine 2,5-Dinitroaniline

2-Chloro-5-nitro-benzamine 2,4-DINITROACETANILIDE 1-Methoxy-2,4-dinitrobenzene 4'-Nitroacetanilide

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Preparation Products

6-Aminoquinoxaline 5-BROMO-6-ISOTHIOCYANATE QUINOXALINE 5-Amino-2-benzimidazolethiol 5-Bromoquinoxalin-6-amine 2-MERCAPTO-5-NITROBENZIMIDAZOLE

6-NITRO-1H-BENZOIMIDAZOLE-2-THIOL Platinum,dichlorobis(dimethylphenylphosphine)-, (SP-4-2)- 1,4-Diamino-2-nitrobenzene 1H-Benzimidazole,1-methyl-5-nitro-(9CI) 5-Nitrobenzimidazole

4-(5-nitro-H-benzimidazol-2-yl)aniline

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4-Nitro-o-phenylenediamine Suppliers

Global( 441)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58

Supplier	Advantage
LEAP CHEM CO., LTD.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 4-Nitro-o-phenylenediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-12-24	4-Nitro-o-phenylenediamine 99-56-9	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-09-08	4-Nitro-o-phenylenediamine 99-56-9	US $0.00 / KG Ton	1KG Ton	99%+	2 tons/month	Zhuhai Hairuide Bioscience and Technology Co., Ltd
2023-02-09	4-Nitro-o-phenylenediamine 99-56-9	US $10.00 / KG	1KG	99%	10 mt	Hebei Guanlang Biotechnology Co., Ltd.

4-Nitro-o-phenylenediamine
99-56-9
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Nitro-o-phenylenediamine
99-56-9
US $0.00 / KG Ton
99%+
Zhuhai Hairuide Bioscience and Technology Co., Ltd

4-Nitro-o-phenylenediamine
99-56-9
US $10.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

4-Nitro-o-phenylenediamine Spectrum

4-Nitro-o-phenylenediamine(99-56-9)MS 4-Nitro-o-phenylenediamine(99-56-9)¹HNMR 4-Nitro-o-phenylenediamine(99-56-9)¹³CNMR 4-Nitro-o-phenylenediamine(99-56-9)IR1 4-Nitro-o-phenylenediamine(99-56-9)IR2 4-Nitro-o-phenylenediamine(99-56-9)Raman

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