3-HYDROXY-3-METHYLGLUTARIC ACID
- CAS No.
- 503-49-1
- Chemical Name:
- 3-HYDROXY-3-METHYLGLUTARIC ACID
- Synonyms
- Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1
- CBNumber:
- CB1454369
- Molecular Formula:
- C6H10O5
- Molecular Weight:
- 162.14
- MDL Number:
- MFCD00002712
- MOL File:
- 503-49-1.mol
- MSDS File:
- SDS
| Melting point | 105-108 °C (lit.) |
|---|---|
| Boiling point | 120 °C / 13mmHg |
| Density | 1.2132 (rough estimate) |
| refractive index | 1.4230 (estimate) |
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | powder to crystal |
| pka | 3.95±0.10(Predicted) |
| color | White to Light yellow |
| Merck | 14,5808 |
| BRN | 1769194 |
| CAS DataBase Reference | 503-49-1(CAS DataBase Reference) |
| FDA UNII | CLA99KCD53 |
| ATC code | C10AX05 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | MA3753000 | |||||||||
| F | 10 | |||||||||
| HS Code | 29181990 | |||||||||
| Toxicity | LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien) | |||||||||
| NFPA 704 |
|
3-HYDROXY-3-METHYLGLUTARIC ACID price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H4392 | 3-Hydroxy-3-methylglutaric acid ≥95% | 503-49-1 | 100mg | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | H4392 | 3-Hydroxy-3-methylglutaric acid ≥95% | 503-49-1 | 1g | $696 | 2024-03-01 | Buy |
| Sigma-Aldrich | 91387 | 3-Hydroxy-3-methylglutaric acid analytical standard | 503-49-1 | 10MG | $63.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 91387 | 3-Hydroxy-3-methylglutaric acid analytical standard | 503-49-1 | 50MG | $113 | 2022-05-15 | Buy |
| TCI Chemical | H0436 | 3-Hydroxy-3-methylglutaric Acid >95.0%(T) | 503-49-1 | 100mg | $250 | 2024-03-01 | Buy |
3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties,Uses,Production
Description
Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.
Chemical Properties
White Solid
Originator
Aligarh Muslim Univ. (India)
Uses
3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.
Uses
antihyperlipoproteinemia
Definition
ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
brand name
LIPOGLUTAREN
Synthesis Reference(s)
Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596
Purification Methods
Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]
3-HYDROXY-3-METHYLGLUTARIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| VladaChem GmbH | +49-7246-3082843 | info@vladachem.de | Germany | 1860 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from 3-HYDROXY-3-METHYLGLUTARIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 3-HYDROXY-3-METHYLGLUTARIC ACID
503-49-1
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-HYDROXY-3-METHYLGLUTARIC ACID
503-49-1
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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