SB 225002
- CAS No.
- 182498-32-4
- Chemical Name:
- SB 225002
- Synonyms
- SB 225002;SB-225002;SB 225002;SB 225002 USP/EP/BP;SB225002 182498-32-4;SB 225002 - CAS 182498-32-4 - Calbiochem;1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea;N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA;N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA;Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-
- CBNumber:
- CB1455331
- Molecular Formula:
- C13H10BrN3O4
- Molecular Weight:
- 352.14
- MDL Number:
- MFCD00954637
- MOL File:
- 182498-32-4.mol
| Boiling point | 401.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.793±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble to 100mM in DMSO and to 50mM in ethanol |
| form | Yellow solid |
| pka | 5.29±0.10(Predicted) |
| color | white to beige |
| Sensitive | Moisture Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | MQBZVUNNWUIPMK-UHFFFAOYSA-N |
| CAS DataBase Reference | 182498-32-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2921490090 | |||||||||
| NFPA 704 |
|
SB 225002 price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0716 | SB 225002 ≥98% (HPLC) | 182498-32-4 | 5mg | $119 | 2024-03-01 | Buy |
| Sigma-Aldrich | 559405 | SB 225002 | 182498-32-4 | 1mg | $113 | 2024-03-01 | Buy |
| TCI Chemical | B6055 | SB 225002 | 182498-32-4 | 10MG | $163 | 2024-03-01 | Buy |
| TCI Chemical | B6055 | SB 225002 | 182498-32-4 | 50MG | $541 | 2024-03-01 | Buy |
| Alfa Aesar | J65387 | SB 225002 | 182498-32-4 | 10mg | $274 | 2023-06-20 | Buy |
SB 225002 Chemical Properties,Uses,Production
Description
CXCR2 (IL-
Uses
SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.
Definition
ChEBI: 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea is a nitrophenol.
Biological Activity
Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.
Biochem/physiol Actions
SB-225002 is a potent nonpeptide inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2 and > 150-fold selectivity over CXCR1 receptors. CXCR2 binds many different immune cell chemoattractants. SB-225002 is crucial for cancer progression and is involved in inflammatory diseases like COPD, rheumatoid arthritis, and ulcerative colitis.
storage
Store at RT
References
1) White et al. (1998), Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration; J. Biol. Chem. 273 10095 2) Du et al. (2013) SB225002 Promotes Mitotic Catastrophe in Chemo-Sensitive and -Resistant Ovarian Cancer Cells Independent of p53 Status In Vitro; PLoS One. 8 e54572 3) Shen et al. (2013), Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation; Int. Immunopharmacol. 16 261 4) Lane et al. (2001), Interleukin-8 Stimulates Human Immunodeficiency Virus Type 1 Replication and Is a Potential New target for Antiretroviral Therapy; J. Virol. 75 8195 5) Wu et al. (2015), CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation; J. Neuroinflammation 12 98
SB 225002 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
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