Costunolide
- CAS No.
- 553-21-9
- Chemical Name:
- Costunolide
- Synonyms
- COSTUNDIDE;costunolid;Costunlide;(3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one;Costulide;NSC 106404;costunoide;COSTUNOLIDE;CUSTUNOLIDE;Cosinolactone
- CBNumber:
- CB1455816
- Molecular Formula:
- C15H20O2
- Molecular Weight:
- 232.32
- MDL Number:
- MFCD00210262
- MOL File:
- 553-21-9.mol
| Melting point | 106-107 °C |
|---|---|
| Boiling point | 385.4±42.0 °C(Predicted) |
| Density | 1.03±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| form | powder |
| color | white to beige |
| InChIKey | HRYLQFBHBWLLLL-GRFSRWIASA-N |
| LogP | 4.049 (est) |
| CAS DataBase Reference | 553-21-9(CAS DataBase Reference) |
| FDA UNII | 4IK578SA7Z |
| NIST Chemistry Reference | Germacra-1(10),4,11(13)-trien-12-oic acid, 6«alpha»-hydroxy-, «gamma»-lactone, (e,e)-(553-21-9) |
Costunolide price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0417 | Costunolide ≥97% (HPLC) | 553-21-9 | 5mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0417 | Costunolide ≥97% (HPLC) | 553-21-9 | 25mg | $458 | 2024-03-01 | Buy |
| TCI Chemical | C2921 | Costunolide >95.0%(HPLC) | 553-21-9 | 25mg | $135 | 2024-03-01 | Buy |
| TCI Chemical | C2921 | Costunolide >95.0%(HPLC) | 553-21-9 | 100mg | $370 | 2024-03-01 | Buy |
| Cayman Chemical | 14743 | Costunolide ≥98% | 553-21-9 | 1mg | $29 | 2024-03-01 | Buy |
Costunolide Chemical Properties,Uses,Production
Description
Costunolide is a germacranolide sesquiterpene lactone extracted from costus oil. With alantolactone and dehydrocostuslactone, it is a component of lactone mix used to elicit reactions in Compositae-sensitive patients. An erythema-multiform-like occupational contact dermatitis case occurred in a chemistry student after accidental exposure to costus oil (CJ Le Coz & JP Lepoittevin, unpublished results).
Chemical Properties
White crystalline powder, soluble in chloroform, derived from woodsy, Inula magnifica, Kerria japonica, Malachite.
Uses
(+)-Costunolide is an inhibitor of osteoclast differentiation, acting as an anti-inflammatory and anti-oxidant agent. It is a sesquiterpene lactone which mediates apoptosis.
Uses
Costunolide is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.
Definition
ChEBI: Costunolide is a germacranolide with anthelminthic, antiparasitic and antiviral activities. It has a role as an anthelminthic drug, an antiinfective agent, an antineoplastic agent, an antiparasitic agent, an antiviral drug and a metabolite. It is a germacranolide and a heterobicyclic compound.
General Description
Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.
Biological Activity
Inhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF- κ B activation. Displays anti-inflammatory, antifungal and antiviral properties.
Biochem/physiol Actions
Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.
Contact allergens
This germacranolide sesquiterpene lactone is extracted from costus oil. With alantolactone and dehydrocostunolide, it is a component of lactone mix used to elicit reactions in patients sensitive to Asteraceae-Compositae. An erythema-multiform-like occupational contact dermatitis case occurred in a chemical student after an accidental exposure to costus oil.
Costunolide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Costunolide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | Costunolide
553-21-9
|
US $0.00-0.00 / kg | 0.10000000149011612kg | ≥98% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2023-02-24 | Costunolide
553-21-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-24 | Costunolide
553-21-9
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Costunolide
553-21-9
- US $0.00-0.00 / kg
- ≥98%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- Costunolide
553-21-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Costunolide
553-21-9
- US $0.00 / mg
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.