Costunolide
- CAS No.
- 553-21-9
- Chemical Name:
- Costunolide
- Synonyms
- COSTUNDIDE;costunolid;Costunlide;(3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one;Costulide;NSC 106404;costunoide;COSTUNOLIDE;CUSTUNOLIDE;Cosinolactone
- CBNumber:
- CB1455816
- Molecular Formula:
- C15H20O2
- Molecular Weight:
- 232.32
- MDL Number:
- MFCD00210262
- MOL File:
- 553-21-9.mol
| Product description | Number | Pack Size | Price |
| Costunolide ≥97% (HPLC) | SML0417 | 5mg | $113.05 |
| Costunolide CRS | Y0001307 | 1 unit | $128 |
| Costunolide ≥97% (HPLC) | SML0417 | 25mg | $471 |
| Costunolide >95.0%(HPLC) | C2921 | 25mg | $135 |
| Costunolide >95.0%(HPLC) | C2921 | 100mg | $370 |
| More product size | |||
| Melting point | 106-107 °C |
|---|---|
| Boiling point | 385.4±42.0 °C(Predicted) |
| Density | 1.03±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +110.0 to +130.0°, c =0.5 in chloroform-d |
| InChI | InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1 |
| InChIKey | HRYLQFBHBWLLLL-GRFSRWIASA-N |
| SMILES | O1C(=O)C(=C)[C@]2([H])CCC(C)=CCCC(C)=C[C@@]12[H] |t:10,15| |
| LogP | 4.049 (est) |
| CAS DataBase Reference | 553-21-9(CAS DataBase Reference) |
| FDA UNII | 4IK578SA7Z |
| NIST Chemistry Reference | Germacra-1(10),4,11(13)-trien-12-oic acid, 6«alpha»-hydroxy-, «gamma»-lactone, (e,e)-(553-21-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
Costunolide price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0417 | Costunolide ≥97% (HPLC) | 553-21-9 | 5mg | $113.05 | 2025-07-31 | Buy |
| Sigma-Aldrich | Y0001307 | Costunolide CRS | 553-21-9 | 1 unit | $128 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0417 | Costunolide ≥97% (HPLC) | 553-21-9 | 25mg | $471 | 2025-07-31 | Buy |
| TCI Chemical | C2921 | Costunolide >95.0%(HPLC) | 553-21-9 | 25mg | $135 | 2025-07-31 | Buy |
| TCI Chemical | C2921 | Costunolide >95.0%(HPLC) | 553-21-9 | 100mg | $370 | 2025-07-31 | Buy |
Costunolide Chemical Properties,Uses,Production
Description
Costunolide is a germacranolide sesquiterpene lactone extracted from costus oil. With alantolactone and dehydrocostuslactone, it is a component of lactone mix used to elicit reactions in Compositae-sensitive patients. An erythema-multiform-like occupational contact dermatitis case occurred in a chemistry student after accidental exposure to costus oil (CJ Le Coz & JP Lepoittevin, unpublished results).
Chemical Properties
White crystalline powder, soluble in chloroform, derived from woodsy, Inula magnifica, Kerria japonica, Malachite.
Uses
(+)-Costunolide is an inhibitor of osteoclast differentiation, acting as an anti-inflammatory and anti-oxidant agent. It is a sesquiterpene lactone which mediates apoptosis.
Uses
Costunolide is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.
Definition
ChEBI: Costunolide is a germacranolide with anthelminthic, antiparasitic and antiviral activities. It has a role as an anthelminthic drug, an antiinfective agent, an antineoplastic agent, an antiparasitic agent, an antiviral drug and a metabolite. It is a germacranolide and a heterobicyclic compound.
General Description
Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.
Biological Activity
Inhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF- κ B activation. Displays anti-inflammatory, antifungal and antiviral properties.
Biochem/physiol Actions
Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.
Contact allergens
This germacranolide sesquiterpene lactone is extracted from costus oil. With alantolactone and dehydrocostunolide, it is a component of lactone mix used to elicit reactions in patients sensitive to Asteraceae-Compositae. An erythema-multiform-like occupational contact dermatitis case occurred in a chemical student after an accidental exposure to costus oil.
Costunolide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accendatech Co., Ltd. | +8613132578992 | yunhao.liu@accendatech.com | China | 251 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3987 | 58 |
Related articles
- Costunolide: A plant extract with anticancer properties
- Costunolide, a biologically potent germacranolide-type SL, is present in several plants, such as Magnolia grandiflora and Tana....
- Nov 6，2024
View Lastest Price from Costunolide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-22 | Costunolide
553-21-9
|
US $0.00 / G/KG | 1G/KG | 99% | 100MT | Anhuyan (Hainan) Biotechnology Co., LTD | |
 |
2026-01-21 | Costunolide
553-21-9
|
US $45.00-122.00 / mg | 97.19% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Costunolide
553-21-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Costunolide
553-21-9
- US $0.00 / G/KG
- 99%
- Anhuyan (Hainan) Biotechnology Co., LTD
-
- Costunolide
553-21-9
- US $45.00-122.00 / mg
- 97.19%
- TargetMol Chemicals Inc.
-
- Costunolide
553-21-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
