1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
- CAS No.
- 25371-96-4
- Chemical Name:
- 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
- Synonyms
- TRIM;I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE;1-(2-Trifluoromethylphenyl)imidazole, 98+%;1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%;2-chloro-3-(dodecylamino)naphthalene-1,4-dione;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%;1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE
- CBNumber:
- CB1457890
- Molecular Formula:
- C10H7F3N2
- Molecular Weight:
- 212.17
- MDL Number:
- MFCD00041206
- MOL File:
- 25371-96-4.mol
| Melting point | 43 °C |
|---|---|
| Boiling point | 75°C 0,02mm |
| Density | 1.3253 (estimate) |
| Flash point | 75°C/0.025mm |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml). |
| form | White solid. |
| pka | 4.96±0.10(Predicted) |
| color | White |
| Sensitive | Light Sensitive |
| BRN | 3955637 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 25371-96-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, LIGHT SENSITIVE | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T7313 | 1-[2-(Trifluoromethyl)phenyl]imidazole | 25371-96-4 | 100mg | $165 | 2024-03-01 | Buy |
| TCI Chemical | T2982 | 1-[2-(Trifluoromethyl)phenyl]imidazole min. 98.0 % | 25371-96-4 | 200MG | $85 | 2024-03-01 | Buy |
| TCI Chemical | T2982 | 1-[2-(Trifluoromethyl)phenyl]imidazole >98.0%(GC) | 25371-96-4 | 1g | $254 | 2024-03-01 | Buy |
| Cayman Chemical | 81310 | TRIM ≥98% | 25371-96-4 | 50mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 81310 | TRIM ≥98% | 25371-96-4 | 100mg | $62 | 2024-03-01 | Buy |
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Chemical Properties,Uses,Production
Description
TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2
Uses
TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.
Definition
ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.
Biological Activity
A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .
Biochem/physiol Actions
Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.
References
1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11605 | 64 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| CHG Opto-Electronic Corporation Limited | 2537653158 16621191650 | 2537653158@qq.com | China | 7397 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
25371-96-4
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
25371-96-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
25371-96-4(1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE)Related Search:
1of4