UBIQUITIN ACTIVATING ENZYME (E1) HUMAN
- CAS No.
- 1523011-82-6
- Chemical Name:
- UBIQUITIN ACTIVATING ENZYME (E1) HUMAN
- Synonyms
- UBIQUITIN ACTIVATING ENZYME (E1) HUMAN
- CBNumber:
- CB1464650
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD07785776
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| Ubiquitin Activating Enzyme (E1) human recombinant, expressed in baculovirus infected Sf21 cells | U5633 | 25μg | $595 |
| Ubiquitin Activating Enzyme E1 human ≥95% (SDS-PAGE) | SRP6147 | 50μg | $528 |
UBIQUITIN ACTIVATING ENZYME (E1) HUMAN price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | U5633 | Ubiquitin Activating Enzyme (E1) human recombinant, expressed in baculovirus infected Sf21 cells | 25μg | $595 | 2025-07-31 | Buy | |
| Sigma-Aldrich | SRP6147 | Ubiquitin Activating Enzyme E1 human ≥95% (SDS-PAGE) | 50μg | $528 | 2025-07-31 | Buy |
UBIQUITIN ACTIVATING ENZYME (E1) HUMAN Chemical Properties,Uses,Production
Uses
Ubiquitin Activating Enzyme E1 human has been used in in vitro and in vivo ubiquitination assays.
General Description
Ubiquitin Activating Enzyme (E1) is responsible for the first step in ubiquitin-protein isopeptide bond formation. E1 catalyzes the activation of the C-terminal carboxyl group of ubiquitin by forming a high-energy thioester bond in an ATP-dependent manner.
Biological Activity
Ubiquitin activating enzyme 1 (UBA1) has a role in cellular protein homeostasis. It is the first enzyme utilized in the pathway to conjugate ubiquitin onto target substrates through an ubiquitin-protein isopeptide bond. The C-terminal glycine of an ubiquitin (G76) is initially adenylated in an ATP dependent manner activating it so it can be transferred to the active site cysteine of UBE1 forming an ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) the ubiquitin is transferred to a specific lysine on a target substrate. The protein has been associated with spinal muscular atrophy (SMA) and Huntingtonμs disease (HD).
UBIQUITIN ACTIVATING ENZYME (E1) HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
UBIQUITIN ACTIVATING ENZYME (E1) HUMAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Merck KGaA | 58 |
