Compound 48/80 (hydrochloride)
- CAS No.
- 848035-21-2
- Chemical Name:
- Compound 48/80 (hydrochloride)
- Synonyms
- C48/80 trihydrochloride;Compound 48/80 trihydrochlorid;Compound 48/80 (hydrochloride)
- CBNumber:
- CB14666319
- Molecular Formula:
- C32H48Cl3N3O3
- Molecular Weight:
- 629.10082
- MDL Number:
- MFCD04108752
- MOL File:
- 848035-21-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P310-P321-P330-P302+P352-P304+P340-P311-P312-P361+P364-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Compound 48/80 (hydrochloride) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22173 | Compound 48/80 (hydrochloride) ≥95% | 848035-21-2 | 100mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 22173 | Compound 48/80 (hydrochloride) ≥95% | 848035-21-2 | 50mg | $50 | 2023-01-06 | Buy |
| ChemScene | CS-0109325 | Compound48/80(trihydrochloride) 98.63% | 848035-21-2 | 100mg | $100 | 2021-12-16 | Buy |
| AK Scientific | 4354EF | 2-[4-Methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride | 848035-21-2 | 100mg | $216 | 2021-12-16 | Buy |
Compound 48/80 (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde condensation products. It is also a histamine releaser and mast cell degranulator. It inhibits the activity of phosphatidylinositol-specific phospholipase C in human platelets.
in vitro
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant ) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.
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in vivo
Compound 48/80 trihydrochloride (0.75 mg/kg; ip; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.
| Animal Model: | 7-week-old Wistar male rats (fasted for 24 hours) |
| Dosage: | 0.75 mg/kg |
| Administration: | Intraperitoneal injection; Killed after 0.5, 3 or 6 h |
| Result: | Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin conc entrations in rats decreased time-dependently thereafter. |
Compound 48/80 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Compound 48/80 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15885 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 18621169109 | market03@meryer.com | China | 27996 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 15102117276 18019707223 | tech@zzbioco.com | China | 12065 | 58 |