ChemicalBook >> CAS DataBase List >>XL413 (hydrochloride)
XL413 (hydrochloride)
- CAS No.
- 2062200-97-7
- Chemical Name:
- XL413 (hydrochloride)
- Synonyms
- XL-413 hydrochloride,XL413 hydrochloride
- CBNumber:
- CB14666854
- Molecular Formula:
- C14H13Cl2N3O2
- Molecular Weight:
- 326.18
- MDL Number:
- MOL File:
- 2062200-97-7.mol
Last updated:2023-05-21 10:59:17
XL413 (hydrochloride) price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 2062200-97-7 | 5mg | $119 | 2024-03-01 | Buy |
Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 2062200-97-7 | 10mg | $223 | 2024-03-01 | Buy |
Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 2062200-97-7 | 25mg | $444 | 2024-03-01 | Buy |
Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 2062200-97-7 | 50mg | $748 | 2023-06-20 | Buy |
ChemScene | CS-1957 | XL413 hydrochloride 99.72% | 2062200-97-7 | 100mg | $900 | 2021-12-16 | Buy |
XL413 (hydrochloride) Chemical Properties,Uses,Production
Description
XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.
XL413 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
XL413 (hydrochloride) Suppliers
Global( 16)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2988 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4394 | 58 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
XL-413 hydrochloride,XL413 hydrochloride
2062200-97-7