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ChemicalBook >> CAS DataBase List >>7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine

7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine

7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Structure
7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine structure
CAS No.
1846570-40-8
Chemical Name:
7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine
Synonyms
CM 579,CM579;Chembl4208004;CM-579, 10 mM in DMSO;6-Methoxy-2-(5-methyl-2-furyl)-N-[(1-methyl-4-piperidyl)methyl]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine;6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine;7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine;4-Quinolinamine, 6-methoxy-2-(5-methyl-2-furanyl)-N-[(1-methyl-4-piperidinyl)methyl]-7-[3-(1-pyrrolidinyl)propoxy]-
CBNumber:
CB14674318
Molecular Formula:
C29H40N4O3
Molecular Weight:
492.65
MDL Number:
MFCD31813701
MOL File:
1846570-40-8.mol
Last updated:2025-05-19 12:35:03
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7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Properties

Boiling point 641.8±55.0 °C(Predicted)
Density 1.143±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 10.09±0.20(Predicted)

7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Chemical Properties,Uses,Production

Description

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].

Uses

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

IC 50

DNA Methyltransferase: 32 nM (IC50); DNMT1: 1.5 nM (Kd); DNMT3A: 92 nM (IC50); DNMT3B: 1000 nM (IC50); G9a: 16 nM (IC50)

References

[1]. San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.

7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38838 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189 mychess007@163.com China 1994 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9364 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
cjbscvictory 13348960310 3003867561@qq.com China 10523 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
TargetMol Chemicals Inc. 		58
Amadis Chemical Company Limited 		58
ShangHai KenEn Chemical Technology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
cjbscvictory 58

View Lastest Price from 7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CM-579 pictures 2025-05-19 CM-579
1846570-40-8
 US $50.00-141.00 / mg 99.62% 10g TargetMol Chemicals Inc.
CM-579 pictures 2025-05-19 CM-579
1846570-40-8
 US $50.00-141.00 / mg 99.62% 10g TargetMol Chemicals Inc.
  • CM-579 pictures
  • CM-579
    1846570-40-8
  • US $50.00-141.00 / mg
  • 99.62%
  • TargetMol Chemicals Inc.
  • CM-579 pictures
  • CM-579
    1846570-40-8
  • US $50.00-141.00 / mg
  • 99.62%
  • TargetMol Chemicals Inc.
7-(3-(pyrrolidin-1-yl)propoxy)-6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)quinolin-4-amine 4-Quinolinamine, 6-methoxy-2-(5-methyl-2-furanyl)-N-[(1-methyl-4-piperidinyl)methyl]-7-[3-(1-pyrrolidinyl)propoxy]- Chembl4208004 CM 579,CM579 CM-579, 10 mM in DMSO 6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine 6-Methoxy-2-(5-methyl-2-furyl)-N-[(1-methyl-4-piperidyl)methyl]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine 1846570-40-8