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Enalapril maleate

Enalapril maleate
Enalapril maleate structure
CAS No.
76095-16-4
Chemical Name:
Enalapril maleate
Synonyms
BQL;Pres;Xanef;Nuril;Envas;Ednyt;MK-421;Unaril;Tenace;Sintec
CBNumber:
CB1467853
Molecular Formula:
C24H32N2O9
Formula Weight:
492.52
MOL File:
76095-16-4.mol

Enalapril maleate Properties

Melting point:
143-144,5°C
alpha 
D25 -42.2° (c = 1 in methanol)
Boiling point:
0°C
Flash point:
0°C
storage temp. 
-20°C Freezer
solubility 
methanol: ≥50 mg/mL, clear, colorless to yellow
form 
powder
pka
pKa1 3.0; pKa2 (25°) 5.4
color 
white to off-white
Water Solubility 
Soluble in water, methanol, and ethanol.
λmax
208nm(MeOH)(lit.)
Merck 
14,3567
InChIKey
OYFJQPXVCSSHAI-QFPUQLAESA-N
CAS DataBase Reference
76095-16-4(CAS DataBase Reference)
FDA UNII
9O25354EPJ
NCI Dictionary of Cancer Terms
PRES
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P280-P281
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-62-63
Safety Statements  22-24/25-36/37-26
RIDADR  3077
WGK Germany  2
RTECS  TW3666000
HS Code  29339900
Toxicity LD50 oral in rat: 2973mg/kg

Enalapril maleate price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 16616 Enalapril maleate salt analytical standard 76095-16-4 50mg $59 2019-12-02 Buy
Sigma-Aldrich 1235300 Enalapril maleate United States Pharmacopeia (USP) Reference Standard 76095-16-4 200mg $352.8 2019-12-02 Buy
TCI Chemical E1010 Enalapril Maleate >98.0%(HPLC)(T) 76095-16-4 1g $59 2020-06-24 Buy
TCI Chemical E1010 Enalapril Maleate >98.0%(HPLC)(T) 76095-16-4 5g $201 2020-06-24 Buy
Alfa Aesar J63932 Enalapril maleate salt 76095-16-4 5g $209 2020-06-24 Buy

Enalapril maleate Chemical Properties,Uses,Production

Description

Enalapril maleate is the second angiotensin converting enzyme inhibitor to reach the marketplace. Like captopril, the first entry in this area, enalapril is useful in the treatment of hypertension and congestive heart failure. It has a longer effective half-life than captopril, allowing once or twice-daily dosing, and appears to have a somewhat lower incidence of side effects.

Chemical Properties

White to Off-White Crystalline Powder

Originator

Merck (USA)

Uses

sunscreen

Uses

An antihypertensive. An angiotensin-converting enzyme (ACE) inhibitor.

Definition

ChEBI: The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angioten in-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal diseas in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.

brand name

RENITEN

General Description

Enalapril maleate, 1-[N[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-L-proline 1 -ethyl estermaleate (Vasotec), is a long-acting ACE inhibitor. It requiresactivation by hydrolysis of its ethyl ester to form thediacid enalaprilat. Enalapril is devoid of the side effects ofrash and loss of taste seen with captopril. These side effectsare similar to those of the mercapto-containing drugpenicillamine. The absence of the thiol group in enalaprilmaleate may free it from these side effects. The half-life is11 hours.

Veterinary Drugs and Treatments

The principle use of enalapril/enalaprilat in veterinary medicine at present is as a vasodilator in the treatment of heart failure. Recent studies have demonstrated that enalapril, particularly when used in conjunction with furosemide, does improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. It may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and protein losing nephropathies.
While ACE inhibitors are a mainstay for treating hypertension in humans, they have not been particularly useful in treating hypertension in dogs or cats.

Enalapril maleate Preparation Products And Raw materials

Raw materials

Preparation Products


Enalapril maleate Suppliers

Global( 324)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21837 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
Shaanxi Dideu Medichem Co. Ltd
+86-15319487004
+86-29-88380327 1015@dideu.com CHINA 3526 58

View Lastest Price from Enalapril maleate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-08 Enalapril maleate
76095-16-4
US $0.00-0.00 / 公斤 1KG 99.0% 600 MT Shaanxi Dideu Medichem Co. Ltd
2018-08-20 Enalapril maleate
76095-16-4
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-04-11 Enalapril maleate
76095-16-4
US $1.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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