JNJ-10229570
- CAS No.
- 524923-88-4
- Chemical Name:
- JNJ-10229570
- Synonyms
- JNJ-10229571;JNJ-10229570;UNII-N9IX402L35;JNJ-10229570 ，S0019;JNJ-10229570, 10 mM in DMSO;JNJ-10229570; JNJ10229570; JNJ 10229570;2,3-Bis(2-methoxyphenyl)-N-phenyl-1,2,4-thiadiazol-5(2H)-imine;JNJ-10229570,MC Receptor,Inhibitor,inhibit,Melanocortin Receptor;N-[2,3-Bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]aniline;N-[2,3-Bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]benzenamine
- CBNumber:
- CB14695492
- Molecular Formula:
- C22H19N3O2S
- Molecular Weight:
- 389.47
- MDL Number:
- MFCD31807596
- MOL File:
- 524923-88-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| JNJ-10229570 >98.0% | CS-0027408 | 5mg | $350 |
| JNJ-10229570 >98.0% | CS-0027408 | 10mg | $500 |
| JNJ-10229570 >98% | orb573015 | 100mg | $838.1 |
| JNJ-10229570 >98.0% | CS-0027408 | 25mg | $1100 |
| JNJ-10229570 >98% | orb573015 | 250mg | $1431.4 |
| More product size | |||
| Boiling point | 541.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 62.5 mg/mL (160.47 mM) |
| form | Solid |
| pka | 0.95±0.20(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | N9IX402L35 |
JNJ-10229570 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0027408 | JNJ-10229570 >98.0% | 524923-88-4 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0027408 | JNJ-10229570 >98.0% | 524923-88-4 | 10mg | $500 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573015 | JNJ-10229570 >98% | 524923-88-4 | 100mg | $838.1 | 2021-12-16 | Buy |
| ChemScene | CS-0027408 | JNJ-10229570 >98.0% | 524923-88-4 | 25mg | $1100 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573015 | JNJ-10229570 >98% | 524923-88-4 | 250mg | $1431.4 | 2021-12-16 | Buy |
JNJ-10229570 Chemical Properties,Uses,Production
Uses
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
in vivo
Topical treatment with JNJ-10229570 of human skins transplanted onto SCID mice result in a marked decrease in sebum-specific lipid production, sebaceous gland's size and the expression of the sebaceous differentiation marker epithelial-membrane antigen (EMA). Topical treatment with 0.05% JNJ-10229570 leads to a distinct reduction in both the steady-state and the newly-synthesized sebum-specific lipids, with lesser effects on triglycerides and cholesterol[1].
References
[1] Eisinger M, et al. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32. DOI:10.1016/j.jdermsci.2011.04.001
JNJ-10229570 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Synmedia Chemical Co., Ltd. | 021-38681880 13817889927 | sales@synmedia-chem.com | China | 249 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2990 | 60 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
View Lastest Price from JNJ-10229570 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-20 | JNJ-10229570
524923-88-4
|
US $112.00-313.00 / mg | 99.06% | 10g | TargetMol Chemicals Inc. |
-
- JNJ-10229570
524923-88-4
- US $112.00-313.00 / mg
- 99.06%
- TargetMol Chemicals Inc.
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