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PROTEIN C

PROTEIN C structure

CAS No.: 42617-41-4

Chemical Name:: PROTEIN C

Synonyms: APC;DP2.5;PROTEIN C;APC, HUMAN;APC protein;HUMAN PROTEIN C;fromhumanplasma;PROTEIN C, HUMAN;activated protein c;PROTEIN C, ACTIVATED

CBNumber:: CB1469635

Molecular Formula:

Molecular Weight:: 0

MDL Number:: MFCD00165567

MOL File:: Mol file

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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PROTEIN C Properties

storage temp.	-20°C
solubility	H₂O: 1 mg/mL
form	lyophilized powder
NCI Dictionary of Cancer Terms	APC
FDA UNII	3Z6S89TXPW
ATC code	B01AD12

SAFETY

Risk and Safety Statements

Hazard Codes	B
Risk Statements	36/37
Safety Statements	36/37-36-26
WGK Germany	3

PROTEIN C price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SAB4200594	Anti-APC (C-terminal) antibody produced in rabbit ~1.0?mg/mL, affinity isolated antibody	42617-41-4	200μL	$511	2024-03-01	Buy
Sigma-Aldrich	P2200	Protein C from human plasma Activated, lyophilized powder, ≥90% (SDS-PAGE)	42617-41-4	0.1mg	$606	2024-03-01	Buy
Usbiological	P9102-36	Protein C	42617-41-4	100ug	$247	2021-12-16	Buy
Usbiological	P9081	Protein C, Activated	42617-41-4	50ug	$306	2021-12-16	Buy
Usbiological	156494	Protein C	42617-41-4	10ug	$355	2021-12-16	Buy

Product number	Packaging	Price	Buy
SAB4200594	200μL	$511	Buy
P2200	0.1mg	$606	Buy
P9102-36	100ug	$247	Buy
P9081	50ug	$306	Buy
156494	10ug	$355	Buy

PROTEIN C Chemical Properties,Uses,Production

Description

Drotrecogin alfa was introduced in the US as a new intravenous treatment for the reduction of mortality in adult patients with severe sepsis associated with acute organ dysfunction. Drotrecogin aifa is the first recombinant activated protein C expressed in human kidney 293 cells. Activated protein C₁ an endogenous serine protease, acts as an antithrombotic via inhibition of factor Va and Vllla, promotes fibrinolysis via inactivation of plasminogen-activator inhibitor-1 and exerts an anti-inflammatory effect by inhibiting the production of inflammatory cytokines (tumor necrosis factor-alpha, interieukin-1 and 6) by monocytes. It was shown that the majority of patients with sepsis have reduced levels of activated protein C. In a baboon model of lethal E. coli sepsis, administration of activated protein C reduced mortality. In a phase III clinical trial, intravenous infusion of drotrecogin alfa at a dose of 24 μg/kg/h over 96 h significantly reduced the risk of death compared with placebo in patients with severe sepsis. However, an increased risk of serious bleeding has been associated with the administration of the drug.

Originator

Lilly (US)

Uses

Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper.

brand name

Xigris

General Description

Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14. Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects. Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes.

Biochem/physiol Actions

Adenomatous Polyposis Coli (APC) has a key role in the proteasome-mediated degradation of β-catenin. APC mutations cause accumulation of β-catenin in the nucleus leading to activation of LEF-1 and/or TCF, and the induction of target genes such as the oncogene c-myc. It is involved in regulation of mitotic chromosome separation and stability.

PROTEIN C Preparation Products And Raw materials

Raw materials

Preparation Products

PROTEIN C Suppliers

Global( 22)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Creative Enzymes	1-516-855-7709	info@creative-enzymes.com	United States	8748	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Guangzhou Tomums Life Science Co., Ltd.	020-31155029 18902330969	sales@tomums.cn	China	4698	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Shanghai Huzhen Industrial Co., LTD	021-60345367 13916550749	sales@shzbio.com	China	9965	58

Supplier	Advantage
Creative Enzymes	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Sigma-Aldrich	80
Guangzhou Tomums Life Science Co., Ltd.	58
Energy Chemical	58
Shanghai Huzhen Industrial Co., LTD	58

42617-41-4(PROTEIN C)Related Search:

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1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide METHYL ISOCYANOACETATE Ethyl isocyanoacetate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

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PROTEIN C, ACTIVATED, HUMAN PROTEIN C PROTEIN C, ACTIVATED PROTEIN C, HUMAN PLASMA PROTEIN C CONTROL PLASMA PROTEIN C, HUMAN PROTEIN C, ACTIVATED, HUMAN PLASMA HUMAN PROTEIN C APC APC, HUMAN adenomatous polyposis of the colon gene Anti-APC, C-Terminal antibody produced in rabbit APC protein DP2.5 ACTIVATED HUMAN PROTEIN C PROTEIN C, ACTIVATED FROM HUMAN PLASMA fromhumanplasma activated protein c protein c from human plasma protein C, des-1-41 light chain activated- BLOOD-COAGULATION FACTOR XIVA Protein C from human plasma Activated, lyophilized powder, >=90% (SDS-PAGE) Native Human Protein C 42617-41-4 Biochemicals and Reagents BioChemical Proteolytic Enzymes Proteolytic Enzymes and Substrates Enzymes, Inhibitors, and Substrates