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Aminophenazone structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Aminophenazone Properties

Melting point:
107-109 °C(lit.)
Boiling point:
373.38°C (rough estimate)
1.0744 (rough estimate)
refractive index 
1.6140 (estimate)
storage temp. 
Crystalline Powder, Crystals and/or Chunks
pKa 5.0 (Uncertain)
Off-white to brownish
Water Solubility 
5.55 g/100 mL
Air & Light Sensitive
Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
CAS DataBase Reference
58-15-1(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro- 1,5-dimethyl-2-phenyl-(58-15-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38-21/22
Safety Statements  26-36-36/37/39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  CD2625000
HazardClass  6.1
PackingGroup  III
HS Code  29331190
Hazardous Substances Data 58-15-1(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1.7 g/kg (Hart)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Aminophenazone price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D8015 4-Dimethylaminoantipyrine reactive nitrogen species scavenger 58-15-1 25g $63.3 2018-11-13 Buy
Sigma-Aldrich D8015 4-Dimethylaminoantipyrine reactive nitrogen species scavenger 58-15-1 100g $175 2018-11-13 Buy
Alfa Aesar B21436 4-(Dimethylamino)antipyrine, 98+% 58-15-1 250g $156 2018-11-13 Buy
Alfa Aesar B21436 4-(Dimethylamino)antipyrine, 98+% 58-15-1 50g $42.7 2018-11-13 Buy
Cayman Chemical 15770 Aminophenazone ≥98% 58-15-1 25g $59 2018-11-19 Buy

Aminophenazone Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder


Antipyretic; analgesic.


Antipyretic;ACTH secretor


ChEBI: A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic proper ies.

brand name

Adexogan;Agevis;Algimicin anttitermico;Amidazopen;Amidozen;Anoixal;Antigripina;Areumal;Axiston;Balbion;Barsedan;Baukal suppositories;Bayer 1387 p;Bronchisan;Brufaneuseol;Butapyrine;Capsyka dr knapf;Capysal;Chinopyrin;Cibalgin;Ciclazon;Clinit;Coffan;Compral;Cusayth;Demolpas;Dentigoa;Depiral c;Dexa escopyrin;Dha 51;Dialpyrin;Digisab;Dimametten;Dimopyrin;Diprin;Dolo-attirin;Dolo-optineural;Dolorphen;Dolovosano;Donobin;Duerin;Dysmensan;Escopyrinus;Espasnatex;Eufibran;Euprogan;Febren;Febrosolvin;Fenodone;Fever;Flivalgin;Flumil;Framidone;Ftalazon;Funapon;Galenopyrin;Glucopirina;Glucopitina;Helvagit-f;Hemicraneal;Hisense-p;Influnal depot;Inst;Irgapyrine;Isoftal;Kalmine;Katareuma;Lagaflex;Latepyrine;Lauroanginol;Manslu;Medispanmin;Meloka;Neuro-demoplast;Nifedon;Nikartrone;Nostress;Optineural(analgesic);Optipax;Osadrine;Osmotipax;P.s.b.p.;Piracodid;Piradenil;Piradol;Pirasco;Piraseptolo.

World Health Organization (WHO)

Aminophenazone, a pyrazolone derivative, has been used as an antiinflammatory and analgesic agent for over a century. Its use has been associated with cases of bone marrow depression and agranulocytosis and more recently it has been claimed to have a carcinogenic potential. Products containing aminophenazone have been formally withdrawn in many countries and marketing has been voluntarily suspended in others. Elsewhere, however, proprietary preparations containing this ingredient may remain available. (Reference: (WHODI) WHO Drug Information, 3, 9, 1977)

General Description

Small colorless crystals or white crystalline powder. Aqueous solution slightly alkaline to litmus. pH (5% water solution) 7.5-9. Odorless. Slightly bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Aminophenazone is sensitive to exposure to light. Aminophenazone is readily attacked by mild oxidizing agents in the presence of water. Aminophenazone is incompatible with acacia, apomorphine, aspirin, chloral hydrate, iodine and tannic acid.

Fire Hazard

Flash point data for Aminophenazone are not available; however, Aminophenazone is probably combustible.

Safety Profile

Human poison by unspecified route. Experimental poison by ingestion, subcutaneous, intramuscular,intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic and reproductive effects. Questionable carcinogen when mixed with NaNO2 (1:l). Mutation data reported. Can cause bone marrow depression resulting in leucopenia. Has been implicated in development of aplastic anemia. A tranquilizer. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

It crystallises from pet ether, sublimes between 80o and 90o, and forms metal complexes. [Beilstein 25 H 452, 25 III/IV 3555.]

Aminophenazone Preparation Products And Raw materials

Raw materials

Preparation Products

Aminophenazone Suppliers

Global( 188)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
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Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
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Mainchem Co., Ltd.
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+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40277 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
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Aminophenazone Spectrum

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