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3-Fluoro-4-methylphenol

CAS No.
452-78-8
Chemical Name:
3-Fluoro-4-methylphenol
Synonyms
3-FLUORO-P-CRESOL;3-Fluoro-p-cresol>3-FLUORO-4-METHYLPHENOL;3-Fluoro-p-cresol (OH=1);2-Fluoro-4-hydroxytoluene;Phenol, 3-fluoro-4-methyl-;3-Fluoro-4-methylphenol, JRD,
CBNumber:
CB1478242
Molecular Formula:
C7H7FO
Molecular Weight:
126.13
MDL Number:
MFCD00143164
MOL File:
452-78-8.mol
Last updated:2023-04-23 13:52:06

3-Fluoro-4-methylphenol Properties

Melting point 72 °C
Boiling point 196 °C
Density 1.17
refractive index 1.5150
Flash point 29 °C
storage temp. Inert atmosphere,Room Temperature
form powder to lump
pka 9.27±0.18(Predicted)
color White to Light yellow to Light orange
Odor Phenol-like
InChI InChI=1S/C7H7FO/c1-5-2-3-6(9)4-7(5)8/h2-4,9H,1H3
InChIKey GJOOCAXPERKNMN-UHFFFAOYSA-N
SMILES C1(O)=CC=C(C)C(F)=C1
CAS DataBase Reference 452-78-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS05
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H227-H302-H312-H314-H318
Precautionary statements  P305+P351+P338-P309-P310-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501
Hazard Codes  Xi,Xn
Risk Statements  21/22-34-52-36-22
Safety Statements  26-36/37/39-60-45
RIDADR  2922
Hazard Note  Irritant
HazardClass  8
HS Code  29081990
NFPA 704
2
3 0

3-Fluoro-4-methylphenol price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F0481 3-Fluoro-p-cresol >98.0%(GC) 452-78-8 1g $32 2024-03-01 Buy
TCI Chemical F0481 3-Fluoro-p-cresol >98.0%(GC) 452-78-8 5g $95 2024-03-01 Buy
Alfa Aesar H31864 3-Fluoro-4-methylphenol, 97% 452-78-8 1g $107 2021-12-16 Buy
Alfa Aesar H31864 3-Fluoro-4-methylphenol, 97% 452-78-8 5g $419 2021-12-16 Buy
TRC F597145 3-Fluoro-4-methylphenol 452-78-8 100mg $45 2021-12-16 Buy
Product number Packaging Price Buy
F0481 1g $32 Buy
F0481 5g $95 Buy
H31864 1g $107 Buy
H31864 5g $419 Buy
F597145 100mg $45 Buy

3-Fluoro-4-methylphenol Chemical Properties,Uses,Production

Uses

3-Fluoro-4-methylphenol is a phenolic derivative and can be used as a pharmaceutical intermediate.

Synthesis

3-Fluoro-4-methylaniline (5g, 39.95Immol) was dissolved in 10% sulfuric acid aqueous solution (100ml). Thereafter, the temperature was lowered to 0°C. thereto sodium nitrate (5.5g, 79.902mmol) was added, and the reaction mixture was stirred at same temperature for 30 minutes. Then the reaction mixture was stirred at 50°C for 30 minutes, and the last time, stirred at 80°C for 5 hours. Ice water was added to quench the reaction, and aqueous layer was extracted with ethyl acetate. Combined organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (n-hexane:ethyl acetate = 8:1) to give 2.26g (yield: 44.8%, colorless oil) of the target compound. 3-fluoro-4-methylphenol, yield 2.26g, 44.8% 1H NMR(400MHz, CDCl3): 6.98(1, J=8.6Hz, 1H), 6.52(m, 2H), 5.82(br, 1H), 2.12(s, 3H).
3-Fluoro-4-methylphenol synthesis

3-Fluoro-4-methylphenol Preparation Products And Raw materials

Global( 185)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Accela ChemBio Inc.
(+1)-858-699-3322 info@accelachem.com United States 19965 58
Shanghai Worldyang Chemical Co.,Ltd.
,+86-21-56795779; +8613651600618 sales@worldyachem.com China 879 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Antai Fine Chemical Technology Co.,Limited
18503026267 info@antaichem.com CHINA 9641 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051 joe@yuhengpharm.com CHINA 21149 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
WinWin Chemical CO., Limited
+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 13849 58

View Lastest Price from 3-Fluoro-4-methylphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Fluoro-4-methylphenol pictures 2021-11-26 3-Fluoro-4-methylphenol
452-78-8
US $0.00-0.00 / KG 1KG 98% EX: 100kgs Unipharm pharmaceutical industry Co., Ltd
	3-FLUORO-4-METHYLPHENOL pictures 2019-12-20 3-FLUORO-4-METHYLPHENOL
452-78-8
US $1.00 / KG 1KG 95%~99% 1ton Career Henan Chemical Co
2-Fluoro-4-hydroxytoluene 3-FLUORO-4-METHYLPHENOL 3-FLUORO-P-CRESOL 3-Fluoro-p-cresol (OH=1) 3-Fluoro-4-methylphenol, JRD, 3-Fluoro-p-cresol> Phenol, 3-fluoro-4-methyl- 452-78-8 Fluorine series Aromatic Phenols Phenol&Thiophenol&Mercaptan Fluorine Compounds Phenols