PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
- CAS No.
- 1229246-07-4
- Chemical Name:
- PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
- Synonyms
- PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem;2,4-Thiazolidinedione, 5-[[2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-5-bromophenyl]methylene]-
- CBNumber:
- CB14814000
- Molecular Formula:
- C19H10BrF6NO3S
- Molecular Weight:
- 526.25
- MDL Number:
- MFCD32671969
- MOL File:
- 1229246-07-4.mol
- MSDS File:
- SDS
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem price More Price(1)
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 μM, respectively), but not that of LAR even at concentrations as high as 100 μM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
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Sigma-Aldrich | 80 |
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
2,4-Thiazolidinedione, 5-[[2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-5-bromophenyl]methylene]-
1229246-07-4
C19H10BrF6NO3S