NFAT Inhibitor, Cell-Permeable - Calbiochem
- CAS No.
- Chemical Name:
- NFAT Inhibitor, Cell-Permeable - Calbiochem
- Synonyms
- NFAT Inhibitor, Cell-Permeable - Calbiochem
- CBNumber:
- CB14817647
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
NFAT Inhibitor, Cell-Permeable - Calbiochem price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 480401-M | NFAT Inhibitor, Cell-Permeable - Calbiochem The NFAT Inhibitor, Cell-Permeable controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. | 1mg | $408 | 2023-01-07 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| 480401-M | 1mg | $408 | Buy |
NFAT Inhibitor, Cell-Permeable - Calbiochem Chemical Properties,Uses,Production
Uses
Use at 1 μM for preventing the activation and proliferation of T cells
General Description
A cell-permeable version of NFAT Inhibitor (Cat. No. 480402) that is modified at the C-terminus with an 11-arginine transduction domain and a 3-glycine linker sequence. Prevents the activation and proliferation of T cells both in vitro (~43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice). Show to be effective in providing immunosuppression in a murine islet xenograft model. Unlike Cyclosporin A (Cat. No. 239835) and FK-506, 11R-VIVIT does not cause side effects outside the immune system as a result of calcineurin (Cat. No. 539568) inhibition, therefore serves as a less toxic alternative for animal studies. The functional half-life of 11R-VIVIT has been estimated to be ~30 h in Jurkat cells.
Biochem/physiol Actions
Primary TargetNFAT
NFAT Inhibitor, Cell-Permeable - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
NFAT Inhibitor, Cell-Permeable - Calbiochem Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |