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Boc-L-Threonine

Boc-L-Threonine structure

CAS No.: 2592-18-9

Chemical Name:: Boc-L-Threonine

Synonyms: BOC-THR-OH;BOC-L-THR-OH;BOC-THREONINE;Boc-Thr-OH 98%;BOC-L-THREONINE;N-Boc-Threonine;Boc-L-Threionine;Boc-Thr-OH, 95+%;Boc-Thr-OH, 98.5%;BOC-L-THREONINE-OH

CBNumber:: CB1491517

Molecular Formula:: C9H17NO5

Molecular Weight:: 219.24

MDL Number:: MFCD00065946

MOL File:: 2592-18-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:50

Product description	Number	Pack Size	Price
Boc-Thr-OH Novabiochem?	8.53065	25g	$185
Boc-Thr-OH Novabiochem?	8.53065	100g	$571
Boc-Thr-OH ≥98.5% (T)	15505	25g	$88
N-(tert-Butoxycarbonyl)-L-threonine >98.0%(T)	B1638	10g	$480
N-Boc-L-threonine	B668005	50g	$360
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Boc-L-Threonine Properties

Melting point	80-82 °C(lit.)
alpha	-8.5 º (c=1, acetic acid)
Boiling point	360.05°C (rough estimate)
Density	1.2470 (rough estimate)
refractive index	-7 ° (C=1, AcOH)
storage temp.	-20°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	powder to crystal
pka	3.60±0.10(Predicted)
color	White to Almost white
optical activity	[α]20/D 8.5±1°, c = 1% in acetic acid
BRN	2331474
Major Application	peptide synthesis
InChI	InChI=1S/C9H17NO5/c1-5(11)6(7(12)13)10-8(14)15-9(2,3)4/h5-6,11H,1-4H3,(H,10,14)(H,12,13)/t5-,6+/m1/s1
InChIKey	LLHOYOCAAURYRL-RITPCOANSA-N
SMILES	C(O)(=O)[C@H]([C@H](O)C)NC(OC(C)(C)C)=O
CAS DataBase Reference	2592-18-9(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36-26

WGK Germany

HS Code

29241990

Storage Class

13 - Non Combustible Solids

NFPA 704

	1
0		0

Boc-L-Threonine price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53065	Boc-Thr-OH Novabiochem?	2592-18-9	25g	$185	2026-03-19	Buy
Sigma-Aldrich	8.53065	Boc-Thr-OH Novabiochem?	2592-18-9	100g	$571	2026-03-19	Buy
Sigma-Aldrich	15505	Boc-Thr-OH ≥98.5% (T)	2592-18-9	25g	$88	2023-06-20	Buy
TCI Chemical	B1638	N-(tert-Butoxycarbonyl)-L-threonine >98.0%(T)	2592-18-9	10g	$480	2026-03-19	Buy
TRC	B668005	N-Boc-L-threonine	2592-18-9	50g	$360	2021-12-16	Buy

Product number	Packaging	Price	Buy
8.53065	25g	$185	Buy
8.53065	100g	$571	Buy
15505	25g	$88	Buy
B1638	10g	$480	Buy
B668005	50g	$360	Buy

Boc-L-Threonine Chemical Properties,Uses,Production

Chemical Properties

WHITE AMORPHOUS POWDER

Uses

N-Boc-L-threonine is an N-Boc-protected form of L-Threonine (T405500). L-Threonine is an essential amino acid that is commonly used as a feed and food additive. L-Threonine is produced in mass quantities by mutant Escherichia coli strains for research and food nutrition purposes. L-Threonine can be naturally found in fish and poultry, and is incorporated in some important proteins in the human body (such as hemoglobin and insulin).

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

72-19-5

24424-99-5

2592-18-9

The general procedure for the synthesis of (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid from L-threonine and di-tert-butyl dicarbonate was as follows: 1. To a methanol (5 mL) solution of L-threonine (400 mg, 3.36 mmol), a water (5 mL) solution of sodium bicarbonate (434 mg, 5.17 mmol) was added, followed by di-tert-butyl dicarbonate (1.07 g, 4.90 mmol). 2. The reaction mixture was stirred at room temperature for 3 days. 3. Upon completion of the reaction, the solvent was removed by vacuum distillation. 4. 4. The residue was diluted with water (20 mL) and washed with ether (2 x 20 mL). 5. The aqueous layer was acidified with saturated aqueous sodium bisulfite and then extracted with 2-methyltetrahydrofuran. 6. The organic layer was dried over anhydrous sodium sulfate and subsequently concentrated in vacuo to afford the title compound (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid as a white solid (730 mg, 99% yield). 7. The product was characterized by 1H NMR (400 MHz, CDCl3) and LC-MS: 1H NMR δ 1.24 (d, 3H), 1.44 (s, 9H), 4.26 (d, 1H), 4.40 (d, 1H), 5.52 (d, 1H), 5.69 (br s, 1H); LCMS Rt = 1.68 min, MS m/z 218 [M + H]+.

References

[1] Patent: WO2013/114250, 2013, A1. Location in patent: Page/Page column 161; 162
[2] Patent: WO2013/110643, 2013, A1. Location in patent: Paragraph 00118; 00119
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 8, p. 1795 - 1802
[4] Patent: CN102993200, 2016, B. Location in patent: Paragraph 0043; 0044; 0045
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5770 - 5781

Boc-L-Threonine synthesis

Synthesis of Boc-L-Threonine from L-Threonine and Di-tert-butyl dicarbonate

Boc-L-Threonine Preparation Products And Raw materials

Raw materials

PLIT-019 TERT-BUTYL 2,3-DIHYDRO-2-OXO-3-OXAZOLECARBOXYLATE Boc-Thr(Bzl)-OH L-THREONINEETHYLESTER Carbonofluoridic acid, 1,1-dimethylethyl ester

Di-tert-butyl dicarbonate Methanol tert-butyl azidoformate 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile L-Threonine

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Preparation Products

2-Pyridinethione 2-Hydroxypyridine N-BOC-(R)-1-AMINO-2-PROPANOL

Boc-L-Threonine Suppliers

Global( 362)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58

View Lastest Price from Boc-L-Threonine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	Boc-L-Threonine 2592-18-9	US $0.00 / Kg/Drum	1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	Boc-L-Threonine 2592-18-9	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	Boc-L-Threonine 2592-18-9	US $5.00-0.10 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Boc-L-Threonine
2592-18-9
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-L-Threonine
2592-18-9
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Boc-L-Threonine
2592-18-9
US $5.00-0.10 / KG
99%
Henan Fengda Chemical Co., Ltd

Boc-L-Threonine Spectrum

Boc-L-Threonine(2592-18-9)MS Boc-L-Threonine(2592-18-9)¹HNMR

2592-18-9(Boc-L-Threonine)Related Search:

L-Threonine N-Carbobenzyloxyglycine tert-Butyl carbazate DI-TERT-BUTYL ETHER BOC-THR(ME)-OH

N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine Boc-Thr(Bzl)-OH Boc-O-tert-butyl-L-threonine BOC-D-THREONINE(BZL)-OH BOC-D-THREONINE extrapure,N-ALPHA-T-BOC-D-THREONINE / (2R,3S),N-ALPHA-T-BOC-D-THREONINE,BOC-D-THREONINE

BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA BOC-THR(P-CHLORO-BZL)-OH DCHA N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID BOC-L-THREONINE DCHA tert-butyl [R-(R*,S*)]-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]-2-hydroxypropyl]carbamate

BOC-THR(BZL)-ONP Methyl N-(tert-butoxycarbonyl)-L-threoninate BPOC-THR(TBU)-OSU

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N-(TERT-BUTOXYCARBONYL)-L-THREONINE 98% N-T-BOC-L-THREONINE CRYSTALLINE Boc-L-Threionine N-ALPHA-T-BUTYLOXYCARBONYL-L-THREONINE N-Boc-L-threonine, 98+% BOC-L-THREONINE extrapure N-(tert-Butoxycarbonyl)-L-threonine, Boc-L-threonine BOC-L-THREONINE BOC-L-THREONINE-OH BOC-L-THR-OH BOC-THREONINE BOC-L-Threonine,98% L-Threonine, N-BOC protected BOC-L-Threonine(BOC-L-Thr-OH) N-Boc-L-threonine Boc-Thr-OH 3-Hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]- tert-Butoxycarbonyl-L-threonine (2S,3R)-2-(tert-Butoxycarbonylamino)-3-hydroxybutanoic acid (2S,3R)-2-(tert-Butoxycarbonylamino)-3-hydroxybutyric acid (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxybutyric acid N-[(1,1-Dimethylethoxy)carbonyl]-L-threonine N-Boc-Threonine Boc-L-threonine≥ 98% (HPLC) N-TERT-BUTYLOXYCARBONYL-L-THREONINE N-(TERT-BUTOXYCARBONYL)-L-THREONINE N-(TERT-BUTOXYCARBONYL)-P-THREONINE N-T-BUTOXYCARBONYL-L-THREONINE N-ALPHA-T-BUTOXYCARBONYL-L-THREONINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-THREONINE N-ALPHA-T-BOC-L-THREONINE Boc-Thr-OH, 95+% (Tert-Butoxy)Carbonyl Thr-OH Boc-Thr-OH, 98.5% N-(tert-Butoxycarbonyl)-L-threonine > Boc-L-Threonine USP/EP/BP (2S,3R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid BOC-THR-OH N-tert-Boc-L-threonine Boc-Thr-OH 98% 2592-18-9 592-18-9 CH3CHOHCHCOOHNHCOOCCH33 Protected & Labeled Amino Acids Boc-Amino Acids Amino Acids (N-Protected) Amino Acid Derivatives Peptide Synthesis Threonine Specialty Synthesis Threonine [Thr, T] Boc-Amino Acids and Derivative Amino Acids Amino Acids (N-Protected) Biochemistry Boc-Amino Acids Boc-Amino acid series