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Robenidine hydrochloride

CAS No.
25875-50-7
Chemical Name:
Robenidine hydrochloride
Synonyms
ROBENIDINE HCL;Robenz;Nugatex;cycostat;Toraxine;khimroside;khimcoccid;Rasexinium;CYCOSTAT66G;chimcoccide
CBNumber:
CB1491966
Molecular Formula:
C15H14Cl3N5
Molecular Weight:
370.66
MDL Number:
MFCD01724404
MOL File:
25875-50-7.mol
MSDS File:
SDS
Last updated:2023-09-26 09:42:43

Robenidine hydrochloride Properties

Melting point 252-254°C
storage temp. 0-6°C
solubility Robenidine hydrochloride possesses a weak solubility in water (<1 mg/L), but is soluble in organic solvents: 94 mg/L in dimethylsulfoxide, 46 mg/L in dimethylformamide, 20 mg/L in pyridine and 6.3 mg/L in ethanol (95%). The Log Kow is 3.3 (EFSA, 2004a).
CAS DataBase Reference 25875-50-7(CAS DataBase Reference)
FDA UNII 8STT15Y392

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  2
RTECS  ME8651000
Toxicity mouse,LD50,oral,390mg/kg (390mg/kg),Journal of Agricultural and Food Chemistry. Vol. 23, Pg. 724, 1975.

Robenidine hydrochloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 33979 Robenidine hydrochloride VETRANAL?,analyticalstandard 25875-50-7 100mg $119 2024-03-01 Buy
TRC R639000 Robenidine hydrochloride 25875-50-7 100mg $80 2021-12-16 Buy
ApexBio Technology C6934 Robenidine hydrochloride 25875-50-7 200mg $85 2021-12-16 Buy
AK Scientific I008 RobenidineHCl 25875-50-7 1g $90 2021-12-16 Buy
Biosynth Carbosynth IB57827 1,3-Bis[(p-chlorobenzylidene)amino]guanidine hydrochloride 25875-50-7 25g $100 2021-12-16 Buy
Product number Packaging Price Buy
33979 100mg $119 Buy
R639000 100mg $80 Buy
C6934 200mg $85 Buy
I008 1g $90 Buy
IB57827 25g $100 Buy

Robenidine hydrochloride Chemical Properties,Uses,Production

Description

Robenidine hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Chemical Properties

white or slightly yellow crystalline powder, odorless, slightly bitter taste. Very slightly soluble in ether and water, easily soluble in dilute acid or dilute alkali solution, the color gradually darkens when exposed to light.

Uses

Robenidine hydrochloride is used as a coccidiostat for use in chickens for fattening and turkeys at a minimum-maximum concentration of 30-36 mg/kg complete feed, and in rabbits for fattening at a minimummaximum concentration of 50-66 mg/kg complete feed withdrawal period of 5 days for all target animals.

Preparation

thiosemicarbazide was formed by addition and rearrangement of sodium thiocyanate with water and hydrazine. Then methylation with dimethyl sulfate and hydrazinolysis to give N.N'-diaminoguanidine sulfate. Then replaced with calcium chloride to N.N'-diaminoguanidine hydrochloride. Finally, it was condensed with p-chlorobenzaldehyde in ethanol again to produce Robenidine hydrochloride with 94% yield.

Antimicrobial activity

Robenidine hydrochloride activity against Eimeria species results from a dual action exerted upon different stages of the parasite as it develops in the intestinal mucosa (Ryley and Wilson, 1971). Initially it acts as a coccidiostat and arrests the development of the first schizont generation. Secondly, robenidine hydrochloride is coccidiocidal, killing the second generation of schizonts and possibly the merozoites. An additional effect against the sexual stage of coccidia development has been observed as well. Robenidine hydrochloride has been shown to be an inhibitor of oxidative phosphorylation (Wong et al., 1972) and is reported to affect the protein metabolism and some other metabolic process of coccidia (Lee and Millard, 1972).

Biological Activity

Robenidine Hydrochloride is an anticoccidial agent mainly for poultry which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. IC50 & Target: MIC50: 8.1 μM (MRSA), 4.7 μM (VRE).
In Vitro: Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed.
In Vivo: The time that the mean plasma concentration exceeds the concentration of 1 μg/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with Robenidine.

Global( 253)Suppliers
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View Lastest Price from Robenidine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Robenidine HCL pictures 2023-09-26 Robenidine HCL
25875-50-7
US $0.00 / kg 1kg 98.00% 20tons Hebei Yanxi Chemical Co., Ltd.
Robenidine hydrochloride pictures 2023-07-05 Robenidine hydrochloride
25875-50-7
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Robenidine Hydrochloride pictures 2023-04-26 Robenidine Hydrochloride
25875-50-7
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
  • Robenidine HCL pictures
  • Robenidine HCL
    25875-50-7
  • US $0.00 / kg
  • 98.00%
  • Hebei Yanxi Chemical Co., Ltd.

Robenidine hydrochloride Spectrum

Robenidine hydrochloride Robenidine HCL Pure 1,3-Bis(4-chlorobenzylideneaMino)guanidine Hydrochloride 2,2'-Bis[(4-chlorophenyl)Methylene]carboniMidic Dihydrazide Hydrochloride ChiMcoccid Hydrochloride KhiMcoccid Hydrochloride Robenidine hyd Robenidine Hydrochoride cycostat 1,3-BIS[(4-CHLOROBENZYLIDENE)AMINO]GUANIDINE MONOHYDROCHLORIDE Robenzidene, Cycostat, Robenz ROBENDINE HCL Carbonimidic dihydrazide, bis(4-chlorophenyl)methylene-, monohydrochloride khimroside CYCOSTAT66G Robenidinhydrochlorid 1,3-bis((p-chlorobenzylidene)amino)-guanidin 1,3-bis((p-chlorobenzylidene)amino)guanidine bis((4-chlorophenyl)methylene)-carbonimidic dihydrazid chimcoccide khimcoccid khimkoktsid khimkoktside 1,3-Bis-(P-cheobenzy-tidene-amino)guanidine robenzidene Robenidine (base and/or unspecified salts) CARBONIMIDICDIHYDRAZIDE,BIS[(4-CHLOROPHENYL)METHYLENE] Robenz 1,3 bis(4-(p-chloro. benzylidene)amino]guanidine ROBENIDINE 98% Suifadimidine(SDM) 1,3-bis((p-chlorobenzylidene)amino)guanidinehydrochloride 1,3-bis((p-chlorobenzylidene)amino)-guanidinmonohydrochloride bis((4-chlorophenyl)methylene)-carbonimidicdihydrazidmonohydrochloride Robenidine Solution, 1000ppm Robenidine Hydrochloride Standard Nugatex Rasexinium Toraxine Robenidine hydrochloride USP/EP/BP Robenidin hydrochloride Robenidine hydrochloride (API) ROBENIDINE HCL Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochlorid Robenidine hydrochloride,inhibit,Robenidine,Parasite,Bacterial,Inhibitor 25875-50-7 C27H14N5CL C15H13CI2N5HCI C15H13Cl2N5HCl C15H14Cl3N5 Pharmaceutical intermediate API Intermediates & Fine Chemicals Pharmaceuticals Inhibitors