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Glycyrrhizic acid ammonium salt

Glycyrrhizic acid ammonium salt
Glycyrrhizic acid ammonium salt structure
CAS No.
53956-04-0
Chemical Name:
Glycyrrhizic acid ammonium salt
Synonyms
GLYCAMIL;icorice);t from g;ammoniate;glycyrram;t from gL;Glycyrrhiz;Magnasweet;ycyrrhiza root (L;GLYCYRRHIZICAMMONIUM
CBNumber:
CB1492372
Molecular Formula:
C42H65NO16
Formula Weight:
839.97
MOL File:
53956-04-0.mol

Glycyrrhizic acid ammonium salt Properties

Melting point:
>200°C (dec.)
Boiling point:
768.56°C (rough estimate)
Density 
1.1846 (rough estimate)
refractive index 
49 ° (C=1.5, EtOH)
FEMA 
2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
storage temp. 
2-8°C
solubility 
Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.
form 
Powder or Crystals
color 
Yellow to yellow-green
optical activity
[α]20/D +48±4°, c = 1% in ethanol: water (1:1)
BRN 
3897076
InChIKey
ILRKKHJEINIICQ-YDYGGSECSA-N
CAS DataBase Reference
53956-04-0
Substances Added to Food (formerly EAFUS)
GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
SCOGS (Select Committee on GRAS Substances)
Ammoniated Glycyrrhizin
EWG's Food Scores
4
FDA UNII
3VRD35U26C
EPA Substance Registry System
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0)
SAFETY
  • Risk and Safety Statements
RIDADR  UN 3077 9 / PGIII
WGK Germany  2
RTECS  LZ6500000
3-10
HS Code  29389090

Glycyrrhizic acid ammonium salt price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000433 Ammonium glycyrrhizate European Pharmacopoeia (EP) Reference Standard 53956-04-0 $190 2021-03-22 Buy
Sigma-Aldrich 01250570 Glycyrrhizic acid ammonium salt primary reference standard 53956-04-0 50mg $238 2019-12-02 Buy
Sigma-Aldrich 1029929 Ammonium glycyrrhizate United States Pharmacopeia (USP) Reference Standard 53956-04-0 100mg $399 2021-03-22 Buy
TCI Chemical G0151 Monoammonium Glycyrrhizinate Hydrate >75.0%(HPLC) 53956-04-0 1g $17 2021-03-22 Buy
TCI Chemical G0151 Monoammonium Glycyrrhizinate Hydrate >75.0%(HPLC) 53956-04-0 25g $59 2021-03-22 Buy

Glycyrrhizic acid ammonium salt Chemical Properties,Uses,Production

Description

§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

Chemical Properties

Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

Chemical Properties

white to slightly yellow powder

Uses

Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.

Uses

anti-cancer agent

Uses

pharmaceutical excipient, GRAS, sweetener

Uses

Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.

Anticancer Research

Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.

Purification Methods

Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]

Glycyrrhizic acid ammonium salt Preparation Products And Raw materials

Raw materials

Preparation Products


Glycyrrhizic acid ammonium salt Suppliers

Global( 373)Suppliers
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Chengdu Biopurify Phytochemicals Ltd.
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View Lastest Price from Glycyrrhizic acid ammonium salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Glycyrrhizic Acid Ammonium Salt
53956-04-0
US $10.00 / Kg/Drum 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-17 Glycyrrhizic acid ammonium salt 53956-04-0
53956-04-0
US $20.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-11-15 Glycyrrhizic acid ammonium salt
53956-04-0
US $80.00 / KG 100KG 99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd

Glycyrrhizic acid ammonium salt Spectrum


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