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Acemetacin

Acemetacin
Acemetacin structure
CAS No.
53164-05-9
Chemical Name:
Acemetacin
Synonyms
k-708;Solart;Emflex;acemix;tv1322;rantudil;TVX-1322;aximeixin;rheumibis;BAY f4975
CBNumber:
CB1492822
Molecular Formula:
C21H18ClNO6
Formula Weight:
415.82
MOL File:
53164-05-9.mol

Acemetacin Properties

Melting point:
151.5°C
Boiling point:
565.5±50.0 °C(Predicted)
Density 
1.2387 (rough estimate)
refractive index 
1.6000 (estimate)
RTECS 
NL3521400
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Practically insoluble in water, soluble in acetone, slightly soluble in anhydrous ethanol.
form 
neat
pka
2.60±0.10(Predicted)
color 
Very fine, pale-yellow crystals from pet eth
Merck 
14,27
CAS DataBase Reference
53164-05-9(CAS DataBase Reference)
FDA UNII
5V141XK28X
ATC code
M01AB11
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300-H310-H330-H300+H310+H330
Precautionary statements  P301+P310a-P304+P340-P320-P330-P501a-P260-P264-P280-P284-P302+P350-P310-P262-P302+P352+P310-P304+P340+P310-P270-P301+P310+P330-P405-P501
Hazard Codes  T+
Risk Statements  26/27/28
Safety Statements  22-25-36/37/39-45-24/25
RIDADR  UN 2811
WGK Germany  3
HazardClass  6.1(a)
PackingGroup  II
HS Code  29339900
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 55.5, 18.42, 24.2, 30.1 orally; 34.1, 51.1, 38.1, 28.3 i.v. (Jacobi, Dell)

Acemetacin price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A1674 Acemetacin analytical standard 53164-05-9 1g $37.3 2021-03-22 Buy
Sigma-Aldrich Y0000810 Acemetacin European Pharmacopoeia (EP) Reference Standard 53164-05-9 y0000810 $190 2020-08-18 Buy
Sigma-Aldrich Y0000810 Acemetacin European Pharmacopoeia (EP) Reference Standard 53164-05-9 $190 2021-03-22 Buy
TCI Chemical A2452 Acemetacin >98.0%(GC)(T) 53164-05-9 5g $75 2021-03-22 Buy
TCI Chemical A2452 Acemetacin >98.0%(GC)(T) 53164-05-9 25g $223 2021-03-22 Buy

Acemetacin Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Originator

Rantudil ,Bayer ,W. Germany ,1980

Uses

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.

Definition

ChEBI: A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activ ty is due to both acemetacin and its major metabolite, indometacin.

Manufacturing Process

25.4 g (0.050 mol) of [1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3- indoleacetoxy]-benzyl acetate were dissolved in 400 ml of glacial acetic acid and hydrogenated on 2.0 g of palladium carbon at room temperature. After the absorption of hydrogen had finished (1 hour), the catalyst was filtered off, the filtrate was concentrated by evaporation under vacuum and the compound was caused to crystallize by adding petroleum ether. The compound melted at 149.5-150.5°C (determined on the micro-Kofler bench); the yield was 19.4 g which corresponds to 93% of the theoretical yield.
The starting material for the above step may be prepared as follows: 5 g (0.016 mol) of N1-(p-methoxyphenyl)-p-chlorobenzhydrazide hydrochloride and 4.75 g (0.018 mol) of benzyl levulinoyloxyacetate were heated in 25 ml of glacial acetic acid for 3 hours at 80°C. The solvent was then evaporated off under vacuum. The residue was taken up in chloroform and the solution was washed neutral by shaking with sodium bicarbonate solution and thereafter with water. After drying the chloroform solution, this was subjected to chromatography on aluminium oxide, the eluate was concentrated by evaporation and the viscous oil remaining as residue was crystallized by adding ether. The compound melted at 94-95°C. The yield was 4.1 g which corresponds to 50.7% of the theoretical yield.

Therapeutic Function

Antiinflammatory

Safety Profile

Poison by ingestion, subcutaneous,intraperitoneal, intravenous, and intramuscular routes. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxic fumesof Cl?? and NOx. An anti-inflammatory agent.

Acemetacin Preparation Products And Raw materials

Raw materials

Preparation Products


Acemetacin Suppliers

Global( 220)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5882 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9664 58

View Lastest Price from Acemetacin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-02 Acemetacin
53164-05-9
US $0.00 / Kg/Bag 1KG 98%min 500kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-19 Acemetacin
53164-05-9
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-08-28 acemetacin
53164-05-9
US $1.90 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd

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