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4-Methoxybenzyl alcohol

Star anise oil Content analysis Toxicity Usage limit Chemical properties Uses Production method
4-Methoxybenzyl alcohol
4-Methoxybenzyl alcohol structure
Chemical Name:
4-Methoxybenzyl alcohol
Molecular Formula:
Formula Weight:
MOL File:

4-Methoxybenzyl alcohol Properties

Melting point:
22-25 °C(lit.)
Boiling point:
259 °C(lit.)
1.113 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.544(lit.)
Flash point:
230 °F
storage temp. 
Store at RT.
alcohol: freely soluble
Liquid After Melting
Clear colorless to yellow
Specific Gravity
6.3 (10g/l, H2O, 20℃)
explosive limit
Water Solubility 
JECFA Number
CAS DataBase Reference
105-13-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzenemethanol, 4-methoxy-(105-13-5)
EPA Substance Registry System
Benzenemethanol, 4-methoxy-(105-13-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-63-62-41-37/38-20/21/22
Safety Statements  26-36-45-36/37/39
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS  DO8925000
Hazard Note  Irritant
HS Code  29094990
Toxicity LD50 orally in rats: 1.2 ml/kg (Woodart)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

4-Methoxybenzyl alcohol price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 136905 4-Methoxybenzyl alcohol 98% 105-13-5 5g $24.6 2018-11-13 Buy
Sigma-Aldrich 136905 4-Methoxybenzyl alcohol 98% 105-13-5 100g $32.4 2018-11-13 Buy
TCI Chemical M0107 4-Methoxybenzyl Alcohol >98.0%(GC) 105-13-5 25g $19 2018-11-22 Buy
TCI Chemical M0107 4-Methoxybenzyl Alcohol >98.0%(GC) 105-13-5 100g $43 2018-11-22 Buy
Alfa Aesar A15559 4-Methoxybenzyl alcohol, 98% 105-13-5 500g $99.7 2018-11-13 Buy

4-Methoxybenzyl alcohol Chemical Properties,Uses,Production

Star anise oil

Star anise oil, also known as anise oil, appears as colorless transparent or light yellow liquid at above 20°C. When the temperature will drop, there will be sheet crystal precipitate with anise aroma and sweetness of the anethole. It is slightly soluble in water and easily soluble in ethanol, ether and chloroform. It belongs to Illicium Linn, magnoliaceae. The fruit is an aggregate fruit, being octagonal, therefore it is commonly known as star anise, also known as aniseed. Star anise oil is a kind of aromatic oil with complex composition, being volatile oil and a little sticky. Its color is gray for the best case while is yellow for slightly worse cases. It tastes sweet and tingling with a strong aroma of star anise. It is agitated at a temperature of 10 to 15 °C upon stirring. Its main ingredient is trans-anethole with a content of up to 80%. It also contains α-pinene, limonene, linalool, safrole, anisic aldehyde, anisone, 4-terpineol, artemisia capillaris, anisaldehyde and other ingredients. Anise oil is a kind of aromatic oil which is strongly technical and is not easy to identify using chemical equipment. The current producing area is still mainly through the buyer with the naked eye and nose smell to identify the quality of star anise.
Anise oil, in the spice industry, is mainly used to extract anethole brain and re-synthesis of anisaldehyde and anisol alcohol (p-methoxybenzyl alcohol, 4-methoxybenzyl alcohol). Some of the spices are widely used in toothpaste, food and soap and cosmetics fragrance. The fruit is commonly used in people's food seasoning spices. At the same time, the anise oil is the major raw material for the synthesis of negative hormone estrone in the pharmaceutical industry. As the octagonal oil is lighter than water, so it can be suspended in the water. The water obtained after oil and water separation contains anise oil after the anise oil returns to the distillation pot for re-distillation to improve the oil yield.

Content analysis

According to the Total Alcohol Assay (OT-5): the amount of acetylated alcohol used for saponification was 1.5 g. The equivalent factor (e) in the calculation is 69.09, or by gas chromatographic nonpolar column method in GT-10-4.


ADI 1 mg/kg (CE);
LD50 1200 mg/kg (rat, oral);

Usage limit

FEMA (mg/kg): soft drink 7.4; cold drink 8.0; candy 11; baked goods 12; pudding class 1.9.
Take moderate as limit (FDA § 172.515, 2000).

Chemical properties

It appears as colorless to slightly yellow liquid or opaque crystals with the relative density of 1.110-1.120, refractive index of 1.543-1.545, the boiling point of about 258-259 °C, freezing point> 23.5 °C, the flash point of 100 °C above and insoluble in water. It is soluble in the same volume of 50% alcohol with an acidity value of 1.0.
It mainly has fennel aroma with a slight cream fragrance and fragrant background. Aromatic odor is mild and can stay long.


1. 4-Methoxybenzyl alcohol mainly used in floral flavor with fragrance flavor, such as hawthorn flowers, jasmine, acacia, shy flowers, acacia, lilac, lily of the valley, violet, magnolia, sunflower, daffodils and so on. It can also be used for the need for chypre spices with vanilla flavor to coordinate the aroma and increase the aroma of beans. It can also be used for chocolate, cocoa and fresh fruit flavor.
2. GB 2760-1996 provides as allowable food flavors. It is mainly used for the preparation of vanilla, chocolate, cocoa, almonds, peaches and other flavor.
3. It is used for the preparation of drugs and spices.
4. It is used as pharmaceutical intermediates.
5. 4-Methoxybenzyl alcohol has a slightly sweet aroma of anise, commonly used in the preparation of jasmine, lilac and other flavors, suitable for deployment of perfume. The goods are allowable food spices provided in China's GB2760-86. It is mainly used to formulate the flavor of vanilla, chocolate, cocoa, almonds and peaches. It can also be used in organic synthesis and as a solvent.
6. It is used as moxonidine intermediates.
7. It is alcohol synthesis spices. It is mainly used as the blending spices of jasmine, cloves, fragrant peas, gardenia and other flavors for perfume and other cosmetics.
8. It can provide the temporary protection for the carbohydrate anti-OH-group.

Production method

It is obtained through the anisaldehyde reduction. The anise, formaldehyde and sodium hydroxide are subject to Cannizzaro reaction in the ethanol to generate p-methoxybenzyl alcohol. After distilling to recycle the ethanol, the resulting oil layer is extracted with benzene, acidified with acetic acid, neutralized by sodium hydrogencarbonate to a weak basicity, washed with water to neutral, then distillation to recover benzene with the residue subjecting to distillation under reduced pressure to obtain p-methoxy Benzyl alcohol.
In methanol solution, apply potassium hydroxide solution for treatment of the mixture of anisaldehyde and formaldehyde, getting mixture of anole alcohol and formic acid. Apply benzene extraction and then purify through distillation.
Use platinum as a catalyst and ferrous chloride as a reductant, obtain it through anisidine hydrogenation.

Chemical Properties


Chemical Properties

Anise Alcohol occurs in vanilla pods and in anise seeds. It is a colorless liquid with a sweet, floral, slightly balsamic odor.


4-Methoxybenzyl Alcohol is used in the preparation of semiconductors, nanosheets and nanocrystals. Also is used as a reagent for various chemical organic reactions such as in the synthesis of quinolin es.


Extremely toxic.

Contact allergens

As a fragrance allergen, anisyl alcohol has to be mentioned by name in cosmetics within the EU.

Safety Profile

Moderately toxic by ingestion. A skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALCOHOLS.

4-Methoxybenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

4-Methoxybenzyl alcohol Suppliers

Global( 302)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19947 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3210 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32606 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6402 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20177 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4696 58
career henan chemical co
+86-371-86658258 CHINA 19975 58
Creasyn Finechem(Tianjin) Co., Ltd. 86-22-83945878,83945171,83945172
4008266163-06019 China 838 68
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76

View Lastest Price from 4-Methoxybenzyl alcohol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 4-Methoxybenzyl alcohol
US $10.00 / KG 25KG 99% 500KG career henan chemical co

4-Methoxybenzyl alcohol Spectrum

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