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Sulfisoxazole

Sulfisoxazole
Sulfisoxazole structure
CAS No.
127-69-5
Chemical Name:
Sulfisoxazole
Synonyms
SIZ;Soxo;nu445;Sosol;Ganda;G-sox;J-Sul;v-Sul;NU 445;Pancid
CBNumber:
CB1495500
Molecular Formula:
C11H13N3O3S
Formula Weight:
267.3
MOL File:
127-69-5.mol

Sulfisoxazole Properties

Melting point:
195°C
Density 
1.3486 (rough estimate)
refractive index 
1.6630 (estimate)
storage temp. 
2-8°C
solubility 
acetone: complete50 mg/ml
pka
5.0(at 25℃)
form 
neat
Water Solubility 
<0.1 g/100 mL at 22.5 ºC
λmax
271nm(MeOH)(lit.)
Merck 
14,8952
BRN 
6737262
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
127-69-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-(127-69-5)
EPA Substance Registry System
Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5- isoxazolyl)-(127-69-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  WO9100000
HazardClass  IRRITANT
HS Code  29350030
Hazardous Substances Data 127-69-5(Hazardous Substances Data)
Toxicity LD50 orally in mice: 6800 mg/kg (Seki)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Sulfisoxazole price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 31739 Sulfisoxazole VETRANAL 127-69-5 250mg $44.3 2018-11-20 Buy
Sigma-Aldrich 1638000 Sulfisoxazole United States Pharmacopeia (USP) Reference Standard 127-69-5 200mg $352.8 2018-11-20 Buy
TCI Chemical U0098 Sulfisoxazole >98.0%(HPLC) 127-69-5 25g $70 2018-11-22 Buy
Cayman Chemical 25980 Sulfisoxazole ≥98% 127-69-5 50mg $55 2018-11-19 Buy
Cayman Chemical 25980 Sulfisoxazole ≥98% 127-69-5 25mg $29 2018-11-19 Buy

Sulfisoxazole Chemical Properties,Uses,Production

Chemical Properties

white to cream powder

Uses

Sulfisoxazole is a sulfonamide based antibacterial that exhibits activity against wide spectrum of gram-negative and gram-positive bacterium.

Definition

ChEBI: A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.

brand name

Gantrisin (Roche).

General Description

Odorless white to yellowish crystalline powder. Slightly bitter taste. Acid to litmus.

General Description

Sulfisoxazole’s plasmahalf-life is 6 hours. This compound is a white, odorless,slightly bitter, crystalline powder. Its pKa is 5.0. At pH 6,this sulfonamide has a water solubility of 350 mg in100 mL, and its acetyl derivative has a solubility of 110 mgin 100 mL of water.Sulfisoxazole possesses the action and the uses of othersulfonamides and is used for infections involving sulfonamide-sensitive bacteria. It is claimed to be effective in thetreatment of Gram-negative urinary infections.

Air & Water Reactions

May be sensitive to prolonged exposure to air and light. Sensitive to heat. Slightly soluble in water.

Fire Hazard

Flash point data for Sulfisoxazole are not available; however, Sulfisoxazole is probably combustible.

Pharmaceutical Applications

3,4-Dimethyl-5-sulfanilamidoisoxazole. It is highly soluble, even in acid urine. The spectrum and potency are typical of the group. It is well absorbed, achieving a concentration of around 20 mg/L 3–4 h after a 2 g oral dose.
Side effects are those common to other sulfonamides. It is less prone than some other members of the group to cause renal problems. Its principal use is in urinary tract infection, and is present in some ophthalmic preparations.

Biological Activity

A selective ET A endothelin receptor antagonist (IC 50 values are 600 and 2200 nM for ET A and ET B receptors respectively).

Safety Profile

Mildly toxic by ingestion. An experimental teratogen. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Sulfisoxazole Preparation Products And Raw materials

Raw materials

Preparation Products


Sulfisoxazole Suppliers

Global( 140)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24648 81
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32492 50
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13074 57

View Lastest Price from Sulfisoxazole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 Sulfisoxazole
127-69-5
US $1.00 / kg 1kg 99% Customized career henan chemical co

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