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DROFENINE HYDROCHLORIDE

CAS No.
548-66-3
Chemical Name:
DROFENINE HYDROCHLORIDE
Synonyms
it-19;trasentinh;DrofeninHCl;DROFENINE HCL;cyclovegantine;cycloadiphenine;hexahydroadiphenine;Drofeninhydrochlorid;LABOTEST-BB LT00244841;DROFENINE HYDROCHLORIDE
CBNumber:
CB1496239
Molecular Formula:
C20H32ClNO2
Molecular Weight:
353.93
MDL Number:
MFCD00034983
MOL File:
548-66-3.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:04

DROFENINE HYDROCHLORIDE Properties

Melting point 145-147°
storage temp. 2-8°C
solubility Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
form Solid
color White to Off-White
FDA UNII MVB31OPW05

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H332-H302-H411
Precautionary statements  P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
WGK Germany  2
RTECS  GU6825000
Toxicity LD50 i.v. in mice: 65.6 mg/kg (Fleisch)

DROFENINE HYDROCHLORIDE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D679000 DrofenineHydrochloride 548-66-3 1g $1020 2021-12-16 Buy
American Custom Chemicals Corporation API0012869 DROFENINE HYDROCHLORIDE 98.00% 548-66-3 500G $4866.02 2021-12-16 Buy
ChemScene CS-4885 Drofeninehydrochloride 98.10% 548-66-3 50mg $100 2021-12-16 Buy
AK Scientific B876 Drofeninehydrochloride 548-66-3 1g $127 2021-12-16 Buy
American Custom Chemicals Corporation API0012869 DROFENINE HYDROCHLORIDE 98.00% 548-66-3 10MG $280.35 2021-12-16 Buy
Product number Packaging Price Buy
D679000 1g $1020 Buy
API0012869 500G $4866.02 Buy
CS-4885 50mg $100 Buy
B876 1g $127 Buy
API0012869 10MG $280.35 Buy

DROFENINE HYDROCHLORIDE Chemical Properties,Uses,Production

Originator

Trasentine A,Ciba

Uses

Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.

Uses

Spasmolytic

Manufacturing Process

17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in 200 parts of acetic acid and hydrogenated over platinum catalyst. After the calculated volume of hydrogen was passed, the catalyst was filtered off and the solvent was removed to dryness. Ether, water and a potassium carbonate solution were added to the remaining oil and were thoroughly shaken. The ether layer was washed with water and dried over potassium carbonate. The solvent was removed, the remaining oil was distilled in vacuum to give 2- (diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.

Therapeutic Function

Spasmolytic

DROFENINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LABOTEST-BB LT00244841 HEXAHYDROADIPHENINE HYDROCHLORIDE DROFENINE HYDROCHLORIDE hexahydroadiphenine DROFENINE HCL 2-(diethylamino)ethylalpha-cyclohexylbenzeneacetate 2-diethylaminoethyl(alpha-phenylcyclohexane)acetatehydrochloride adipheninehhydrochloride alpha-cyclohexylbenzeneaceticacid2-(diethylamino)ethylesterhydrochloride alpha-phenylcyclohexaneaceticacid2-(diethylamino)ethylesterhydrochloride alpha-phenyl-cyclohexylessigsaeure-2-diaethylamino-aethylester-hydrochlorid cycloadiphenine cycloadipheninehydrochloride cyclohexylphenylacetyldiethylaminoethanolhydrochloride cyclospasmol(tempelhof) cyclovegantine it-19 trasentine-6hhydrochloride trasentinh 2-(2-cyclohexyl-2-phenylacetoxy)ethyldiethylammonium chloride 2-diethylaminoethyl alpha-cyclohexylphenylacetate hydrochloride DrofeninHCl Drofeninhydrochlorid Drofenine,Cholinesterase (ChE),Drofenine hydrochloride,Inhibitor,inhibit,Hexahydroadiphenine 548-66-3 C20H31NO2HCl Analytical Chromatography Product Catalog Alphabetic Analytical Standards DJ - DZ