Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1,2-Benzisothiazol-3(2H)-one

1,2-Benzisothiazol-3(2H)-one

1,2-Benzisothiazol-3(2H)-one Structure
1,2-Benzisothiazol-3(2H)-one structure
CAS No.
2634-33-5
Chemical Name:
1,2-Benzisothiazol-3(2H)-one
Synonyms
BIT;1,2-BENZISOTHIAZOLIN-3-ONE;BENZISOTHIAZOLINONE;BIT-85;Benzo[d]isothiazol-3(2H)-one;BENZISOTHIAZOLONE;proxel;1,2-Benzisothiazolin;Benzisothiazolin-3-on (BIT);1,2-benzisothiazoline-3-one
CBNumber:
CB1496512
Molecular Formula:
C7H5NOS
Molecular Weight:
151.19
MDL Number:
MFCD00044001
MOL File:
2634-33-5.mol
MSDS File:
SDS
Last updated:2024-03-11 22:19:25
Request For Quotation

1,2-Benzisothiazol-3(2H)-one Properties

Melting point 154-158 °C(lit.)
Boiling point 360°C (rough estimate)
Density 1.2170 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5500 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in dichloromethane, dimethyl sulfoxide, methanol.
pka 10.19±0.20(Predicted)
color White to Light yellow to Light orange
Water Solubility 1.288g/L at 20℃
InChIKey DMSMPAJRVJJAGA-UHFFFAOYSA-N
LogP 0.7 at 20℃
Indirect Additives used in Food Contact Substances 1,2-BENZISOTHIAZOLIN-3-ONE
FDA 21 CFR 176.300; 177.2600
CAS DataBase Reference 2634-33-5
EWG's Food Scores 3-7
FDA UNII HRA0F1A4R3
EPA Substance Registry System 1,2-Benzisothiazolin-3-one (2634-33-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07,GHS09
Signal word  Danger
Hazard statements  H302-H315-H317-H318-H400
Precautionary statements  P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,N
Risk Statements  22-38-41-43-50
Safety Statements  24-26-37/39-61
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  DE4620000
HazardClass  9
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29339900
Toxicity LD50 oral in rat: 1020mg/kg
NFPA 704
1
2 0

1,2-Benzisothiazol-3(2H)-one price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB4502639 Anti-SIRP α1, C-Terminal antibody produced in rabbit affinity isolated antibody 100μG $506 2024-03-01 Buy
Sigma-Aldrich 561487 1,2-Benzisothiazol-3(2H)-one 97% 2634-33-5 5g $74.3 2024-03-01 Buy
Sigma-Aldrich 561487 1,2-Benzisothiazol-3(2H)-one 97% 2634-33-5 25g $216 2024-03-01 Buy
TCI Chemical B2430 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) 2634-33-5 25g $82 2024-03-01 Buy
TCI Chemical B2430 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) 2634-33-5 100g $239 2024-03-01 Buy
Product number Packaging Price Buy
SAB4502639 100μG $506 Buy
561487 5g $74.3 Buy
561487 25g $216 Buy
B2430 25g $82 Buy
B2430 100g $239 Buy

1,2-Benzisothiazol-3(2H)-one Chemical Properties,Uses,Production

Description

BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.

Chemical Properties

Yellow Powder

Uses

Isothiazolinone BIT is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils. It exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.

Uses

Antimicrobial agent.

Definition

ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.

Application

1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.

General Description

1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.

Flammability and Explosibility

Not classified

Contact allergens

1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Toxicity evaluation

Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment.  BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.

1,2-Benzisothiazol-3(2H)-one synthesis

2527-57-3
5697-20-1
2634-33-5
Synthesis of 1,2-Benzisothiazol-3(2H)-one from 2,2'-dithiobisbenzamide and 2-sulfanylbenzamide

1,2-Benzisothiazol-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-Chloro-1,2-benzisothiazole 3-(1-Piperazinyl)-1,2-benzisothiazole 2-(benzo[d]isothiazol-3-ylaMino)ethanol 3-(3-Oxo-1,2-benzisothiazol-2(3H)-yl)propanoic acid

1,2-Benzisothiazol-3(2H)-one Suppliers

Global( 584)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Aumei New Material Co., Ltd.
+86-027-87366298 +8615927270571 tianyi@skbiology.cn China 294 58
WUXI HONOR SHINE CHEMICAL CO.,LTD
0510-83593312 +8613665125081 sales@honorshinechem.com China 61 58
Hebei Anda Technology Co., LTD
+86-19831998802 106@hebeianda.cn China 293 58
Suzhou Genemill Biotechnology Co.,Ltd
+86-0512-65917170; +8615862502491 aimeegao@genemill.com China 39 58
Changzhou AniKare Pharmatech Co., Ltd.
+86-0519-8359-8696 +8618018249389 sales@anikare.com China 8382 58
Shandong Juchuang Chemical Co., LTD 		+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Supplier Advantage
Hubei Aumei New Material Co., Ltd.
58
WUXI HONOR SHINE CHEMICAL CO.,LTD
58
Hebei Anda Technology Co., LTD
58
Suzhou Genemill Biotechnology Co.,Ltd
58
Changzhou AniKare Pharmatech Co., Ltd.
58
Shandong Juchuang Chemical Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

Related articles

  • 1,2-Benzisothiazol-3(2H)-one(BIT)
  • 1,2-Benzisothiazol-3(2H)-one, also known as benzisothiazolone or BIT, belongs to the class of organic compounds known as benzo....
  • Apr 22，2022

View Lastest Price from 1,2-Benzisothiazol-3(2H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2-Benzisothiazol-3(2H)-one pictures 2024-03-11 1,2-Benzisothiazol-3(2H)-one
2634-33-5
 US $35.00-15.00 / kg 500kg 99.9 200tons Shandong Juchuang Chemical Co., LTD
NeoCide BIT-10 preservative pictures 2024-02-20 NeoCide BIT-10 preservative
2634-33-5
 US $0.00 / Liter 1Liter 0.095—0.105 100tons Suzhou Genemill Biotechnology Co.,Ltd
BIT-10 Preservative pictures 2024-02-20 BIT-10 Preservative
2634-33-5
 US $0.00 / Liter 1Liter 0.095—0.105 100tons Suzhou Genemill Biotechnology Co.,Ltd
  • BIT-10 Preservative pictures
  • BIT-10 Preservative
    2634-33-5
  • US $0.00 / Liter
  • 0.095—0.105
  • Suzhou Genemill Biotechnology Co.,Ltd

1,2-Benzisothiazol-3(2H)-one Spectrum

1,2-Benzisothiazol-3(2H)-one(2634-33-5)MS1,2-Benzisothiazol-3(2H)-one(2634-33-5)1HNMR1,2-Benzisothiazol-3(2H)-one(2634-33-5)13CNMR1,2-Benzisothiazol-3(2H)-one(2634-33-5)IR11,2-Benzisothiazol-3(2H)-one(2634-33-5)IR2

2634-33-5(1,2-Benzisothiazol-3(2H)-one)Related Search:

4-(Diethylamino)salicylaldehyde Benzothiazole 5-Chlorovaleric acid 2-Mercaptobenzothiazole Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
2,2'-Dithiobis(benzothiazole) Acetophenone DL-α-Tocopherol Diphenolic acid Propiconazole
2-Methyl-4-isothiazolin-3-one Pralmorelin JL-80028 JL-1500A8 YOULIAOSHAJUNJI
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Wood mold remover 5-Bromo-5-nitro-1,3-dioxane

1of4

1,2-Benzisothiazolin-3-One(MIT) 2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(7),8,10-trien-5-one 1,2-benzo-isothiazolin-3-ketone Acticide BIT Apizas AP-DS Bestcide 200K Bioban BIT 20DPG Canguard BIT Canguard BIT 20DPG Benzisothiazolin-3-one (BIT) Benzo[d]isothiazol-3(2H)-one, 98% 99% Benziothiazolinone solution Anti-SIRP α1, C-Terminal antibody produced in rabbit brain Ig-like molecule with tyrosine-based activation motifs inhibitory receptor SHPS-1 Macrophage fusion receptor 1,2-Benzisothiazol-3-ol Benzocil Proxel AB 1-Thia-2-azaindan-3-one 2,3-Dihydro-1,2-benzisothiazole-3-one Proxan Proxel XL proxil Benzisothiazolin-3-one 1,2-benzothiazol-3-one Benzo[d]Isothiazol-3-ol Benzoisothiazol-3-one 1,2-Benzisothiazol-3(2H)-one ,98% 1,2-Benzisothiazol-3(2H)-one [for BiocheMical Research] 2-Benzisothiazolin-3-one 1,2-Benzisothiazol-3(2H-)-one Benziothiazolinone solution,100ppm BIT-20 1,2-BENZISOTHAZOL-3(2H)-ONE 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,2-BENZISOTHIAZOL-3-ONE (BIT) 1,2-Benzisothiazoline-3(2H)-one 1,2-BENZISOTHIAZOL-3(2H)-ONE HYDRATE 1,2-BENZISOTHIAZOLIN-3-ONE (BIT) 98.5% 1,2-Benisothiazolin-3-One-2-Sodium Salt 1,2-Benzisothiazolin-3-One(Bit) 1,2-Bezisothiazolin-3-One(Bit) 1.2-Benzisothiazol-3(2H)-on 3-Hydroxy-1,2-benzisothiazole BIOCIDE--BIT 1,2-BENZISOTHLAZOLIN-3-ONE 1,2-BENZOISOTHIAZOLINE-3-ONE 1,2-BENZISOTHIAZOLINON-3-ONE PROXELHL 2-Hydrobenzo[d]isothiazol-3-one 1,2-benzisothiazol-3(2H)-one 1,2-benzisothiazolin-3-one 1,2-Benzisothiazol Benziothiazolinone Solution, 1000ppm 1,2-Benzisothiazoline-3-on 1,2-Benzisothiazolin-3-one BIT IN STOCK 2,3-dihydro-3-oxo-1,2-benzisothiazole BIT20/Proxel Gxl