ChemicalBook >> CAS DataBase List >>TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
- CAS No.
- 186020-66-6
- Chemical Name:
- TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
- Synonyms
- HO-PEG3-tBu;OH-PEG3-TBA;HO-PEG3-COOtBu;OH-PEG3-(CH2)2-Boc;HO-PEG3-CH2CH2COOtBu;OH-PEG3-CH2CH2COOtBu;HO-PEG3-t-Butyl ester;Hydroxy-PEG4-t-butyles;Hydroxy-PEG3-(CH2)2-Boc;HO(CH2CH2O)3CH2CH2COOT-BU
- CBNumber:
- CB1497771
- Molecular Formula:
- C13H26O6
- Molecular Weight:
- 278.34
- MDL Number:
- MFCD03791106
- MOL File:
- 186020-66-6.mol
- MSDS File:
- SDS
Last updated:2024-03-25 20:41:16
| Boiling point | 365.8±27.0 °C(Predicted) |
|---|---|
| Density | 1.052 g/mL at 20 °C (lit.) |
| refractive index |
n |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO |
| form | clear liquid |
| pka | 14.36±0.10(Predicted) |
| color | Colorless to Light yellow to Light orange |
| BRN | 7638988 |
| CAS DataBase Reference | 186020-66-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P362+P364 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HS Code | 2918999090 | |||||||||
| NFPA 704 |
|
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 83062 | tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate ≥97.0%(GC) | 186020-66-6 | 5G | $138.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 83062 | tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate ≥97.0%(GC) | 186020-66-6 | 1g | $78.2 | 2023-06-20 | Buy |
| TCI Chemical | B5587 | tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate >97.0%(GC) | 186020-66-6 | 1g | $68 | 2024-03-01 | Buy |
| TCI Chemical | B5587 | tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate >97.0%(GC) | 186020-66-6 | 5g | $272 | 2024-03-01 | Buy |
| TRC | B809908 | tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate | 186020-66-6 | 100mg | $60 | 2021-12-16 | Buy |
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties,Uses,Production
Description
Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Biological Activity
Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Non-cleavable < span> | PEGs
| Alkyl/ether
|
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials
Global( 134)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
View Lastest Price from TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-25 | Hydroxy-PEG3-t-butyl ester
186020-66-6
|
US $0.00 / g | 25g | >98.00% | 25g | Xian confluore Biological Technology Co., Ltd. | |
 |
2019-07-06 | TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
186020-66-6
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- Hydroxy-PEG3-t-butyl ester
186020-66-6
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
-
- TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
186020-66-6
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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186020-66-6
peg