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OXAZOLAM METHANOL SOLUTION

OXAZOLAM METHANOL SOLUTION structure

CAS No.: 24143-17-7

Chemical Name:: OXAZOLAM METHANOL SOLUTION

Synonyms: Nebusn;Toccata;Serenal;Tranquit;Hializan;oxazolam;Oxazolazepam;Serenal (Japanese);o-2-methyl-11b-phenyl-;OXAZOLAM METHANOL SOLUTION

CBNumber:: CB1498314

Molecular Formula:: C18H17ClN2O2

Molecular Weight:: 328.79

MDL Number:

MOL File:: 24143-17-7.mol

Last updated:2023-05-15 10:43:31

OXAZOLAM METHANOL SOLUTION Properties

Melting point	187°C
Boiling point	495.8±45.0 °C(Predicted)
Density	1.2065 (rough estimate)
refractive index	1.5400 (estimate)
Flash point	11 °C
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.85±0.60(Predicted)
form	A solid
FDA UNII	1V2WI2NA1C

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H319-H315-H331
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25-36/38-23/25
Safety Statements	16-36/37-45-24
Toxicity	LD50 orl-mus: 5200 mg/kg NYKZAU 66,107,70
DEA Controlled Substances	CSCN: 2839 CSA SCH: Schedule IV NARC: No

OXAZOLAM METHANOL SOLUTION Chemical Properties,Uses,Production

Originator

Serenal,Sankyo,Japan,1970

Uses

A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).

Definition

ChEBI: Oxazolam is an organic molecular entity and a hemiaminal ether.

Manufacturing Process

To a solution of 12.0 g of 5-chloro-2-chloroacetylaminobenzophenone and 3.2 g of isopropanolamine in 100 ml of ethanol was added 3.3 g of sodium acetate.
The resulting mixture was heated under reflux with stirring for 12 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off.
The residue was recrystallized from ethanol to give 10.6 g of the desired product melting at 186°C to 188.5°C.

Therapeutic Function

Tranquilizer

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion.An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí and NOx.

OXAZOLAM METHANOL SOLUTION Preparation Products And Raw materials

Raw materials

5-CHLORO-2-CHLOROACETYLAMINOBENZOPHENONE (S)-(+)-1-Amino-2-propanol

Preparation Products

24143-17-7(OXAZOLAM METHANOL SOLUTION)Related Search:

1-(Benzylamino)propan-2-ol OXAZOLAM METHANOL SOLUTION 2-(1-phenylethylamino)ethanol 2-AMINO-5-CHLOROBENZYL ALCOHOL 2-amino-5-chloro-diphenyl methanol

N-Methyl 4-chloro-2-(methoxymethyl)aniline trans-Oxazolam 1-(3-Chlorophenyl)-1-ethanol 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 2-DIMETHYLAMINOMETHYL-ANILINE

2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 2-(DIPHENYLMETHOXY)-N-METHYLETHYLAMINE 2-AMINOBENZHYDROL 2-(2-HYDROXYETHYLAMINO)-N-PHENYLACETAMIDE 2-(2-HYDROXYETHYLAMINO)-N-(4-CHLOROPHENYL)ACETAMIDE

N1-(3-CHLOROBENZYL)-N1-METHYLETHANE-1,2-DIAMINE N-ETHYL-M-CHLOROBENZYLAMINE (R,S)-1,3,4,5-TETRAHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE HYDROCHLORIDE

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Serenal Tranquit OXAZOLAM METHANOL SOLUTION OXAZOLAM--DEA SCHEDULE IV ITEM Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyl- (8CI, 9CI) Serenal (Japanese) Nebusn Toccata 10-Chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyloxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one 10-Chloro-2-methyl-11b-phenyl-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one Benzo(6,7)-1,4-diazepino-(5,4-b)-oxazol-6-one, 10-chloro-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenyl- benzo(6,7)-1,4-diazepino-(5,4-b)-oxazol-6-one,10-chloro-2,3,5,6,7,11b-hexahydr Hializan o-2-methyl-11b-phenyl- oxazolam Oxazolazepam Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyl- 10-chloro-2-methyl-11b-phenyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one OXAZOLAM METHANOL SOLUTION USP/EP/BP 24143-17-7 Aromatics Heterocycles Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals