SKI II
- CAS No.
- 312636-16-1
- Chemical Name:
- SKI II
- Synonyms
- SphK-I2;CS-1145;SKI II;SKI-II;SKI II - SKI 2;SKI II (SphK-I2);SKI II USP/EP/BP;SKIII(SphK-I2), >98%;Sphingosine Kinase Inhibitor;Sphingosine Kinase Inhibitor 2;SKI II (Sphingosine Kinase Inhibitor)
- CBNumber:
- CB1498400
- Molecular Formula:
- C15H11ClN2OS
- Molecular Weight:
- 302.78
- MDL Number:
- MFCD00733553
- MOL File:
- 312636-16-1.mol
- MSDS File:
- SDS
| Boiling point | 507.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.415±0.06 g/cm3(Predicted) |
| RTECS | SK5900000 |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20 mg/mL |
| form | solid |
| pka | 10.17±0.26(Predicted) |
| color | off-white |
| Sensitive | Air & Light Sensitive |
| CAS DataBase Reference | 312636-16-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
SKI II price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S5696 | SKI II ≥98% (HPLC), solid | 312636-16-1 | 10mg | $209 | 2024-03-01 | Buy |
| Sigma-Aldrich | S5696 | SKI II ≥98% (HPLC), solid | 312636-16-1 | 50mg | $639 | 2024-03-01 | Buy |
| Alfa Aesar | J67479 | SKI-II, 98% | 312636-16-1 | 10mg | $115 | 2021-12-16 | Buy |
| Cayman Chemical | 10009222 | Sphingosine Kinase Inhibitor 2 ≥95% | 312636-16-1 | 5mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 10009222 | Sphingosine Kinase Inhibitor 2 ≥95% | 312636-16-1 | 10mg | $76 | 2024-03-01 | Buy |
SKI II Chemical Properties,Uses,Production
Uses
SKI II is a nonlipid inhibitor of sphingosine kinase. SKI II s orally bioavailable and has shown significant inhibition of tumor growth in mice.
Definition
ChEBI: 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]phenol is a substituted aniline.
Biological Activity
Selective non-lipid inhibitor of sphingosine kinase (IC 50 = 0.5 μ M); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKC α at concentrations up to 60 μ M. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC 50 = 0.9-4.6 μ M).
Biochem/physiol Actions
Sphingosine kinase (SK) plays a pivotal role in regulating tumor growth and SK can act as an oncogene. Expression of SK RNA is significantly elevated in a variety of solid tumors, compared with normal tissue from the same patient. A number of novel inhibitors of human SK were identified, and several representative compounds were characterized in detail. These compounds demonstrated activity at sub- to micromolar concentrations, making them more potent than any other reported SK inhibitor, and were selective toward SK compared with a panel of human lipid and protein kinases. Kinetic studies revealed that the compounds were not competitive inhibitors of the ATP-binding site of SK. 4-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-phenol (SKI-II) inhibitor is orally bioavailable, detected in the blood for at least 8 h, and showed a significant inhibition of tumor growth in mice with IC50 = 0.5 μM; SKI II does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCa at concentrations up to 60 μM.SKI II induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM).
storage
Store at -20°C
References
[1] french kj, schrecengost rs, lee bd, zhuang y, smith sn, eberly jl, yun jk, smith cd. discovery and evaluation of inhibitors of human sphingosine kinase. cancer res. 2003 sep 15;63(18):5962-9.
SKI II Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
